2-chloro-5-(trifluoromethoxy)pyrimidine | 1261812-52-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-chloro-5-(trifluoromethoxy)pyrimidine
• CAS: 1261812-52-5
• 化学式: C₅H₂ClF₃N₂O
• 分子量: 198.532
• InChiKey: XRSAABPVASYNIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-chloro-5-(trifluoromethoxy)pyrimidine 在 ammonium hydroxide 作用下， 以94 %的产率得到5-(Trifluoromethoxy)pyrimidin-2-amine
  参考文献：
  名称：

  [EN] IMIDAZOPYRIDINE AMIDES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF BACTERIAL INFECTIONS
  [FR] AMIDES D'IMIDAZOPYRIDINE ET COMPOSÉS APPARENTÉS DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT D'INFECTIONS BACTÉRIENNES

  摘要：

  The present invention relates to the following compounds (I) wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of tuberculosis (e.g. in combination).

  公开号：

  WO2023073090A1
• 作为产物：
  描述：

  O-(2-chloropyrimidin-5-yl) ethylsulfanylmethanethioate 在 1,3-二溴-5,5-二甲基海因 、 氟化氢吡啶 作用下， 以 二氯甲烷 为溶剂， 以59 %的产率得到2-chloro-5-(trifluoromethoxy)pyrimidine
  参考文献：
  名称：

  [EN] PYRIDAZINONE DERIVATIVES USEFUL AS T CELL ACTIVATORS
  [FR] DÉRIVÉS DE PYRIDAZINONE UTILES EN TANT QU'ACTIVATEURS DE LYMPHOCYTES T

  摘要：

  Disclosed herein are oxime compounds having the structure of Formula (I'): or a pharmaceutically acceptable salt, solvate, hydrate, isomer, tautomer, racemate, or isotope thereof, wherein L1, L2, R1, R2, R3, R4, R7, n, and r are as defined herein. Pharmaceutical compositions comprising them, processes for preparing them and uses of them to treat or prevent diseases, disorders and conditions are also provided. The compounds are inhibitors of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ) and are useful in the treatment of diseases, disorders and conditions related to DGKα and / or DGKζ activity. In particular, the compounds are useful for treating viral infections and proliferative disorders, such as cancer.

  公开号：

  WO2023122778A1

文献信息

• [EN] BICYCLIC TETRAHYDROTHIAZEPINE DERIVATIVES<br/>[FR] DÉRIVÉS BICYCLIQUES DE TÉTRAHYDROTHIAZÉPINE
  申请人：[en]F. HOFFMANN-LA ROCHE AG

  公开号：WO2024033389A1

  公开（公告）日：2024-02-15

  The present invention provides new bicyclic tetrahydrothiazepine derivatives having the general formula (I) wherein R1, R2and R4are as defined herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.