[Diethoxyphosphoryl-(8-methyltetrazolo[1,5-a]quinolin-4-yl)methyl] acetate | 1220960-37-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: [Diethoxyphosphoryl-(8-methyltetrazolo[1,5-a]quinolin-4-yl)methyl] acetate
• CAS: 1220960-37-1
• 化学式: C₁₇H₂₁N₄O₅P
• 分子量: 392.351
• InChiKey: XYRNZWDCTQLMPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  105
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  diethyl hydroxy(8-methyltetrazolo[1,5-a]quinolin-4-yl)methylphosphonate 、 乙酸酐 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 生成 [Diethoxyphosphoryl-(8-methyltetrazolo[1,5-a]quinolin-4-yl)methyl] acetate
  参考文献：
  名称：

  Synthesis, in vitro antibacterial and antifungal evaluations of new α-hydroxyphosphonate and new α-acetoxyphosphonate derivatives of tetrazolo [1, 5-a] quinoline

  摘要：

  A series of new alpha-hydroxyphosphonate and alpha-acetoxyphosphonate derivatives have been synthesized for the first time of tetrazolo [1, 5-a] quinoline derivatives. Elemental analysis, IR, H-1 NMR, C-13 NMR and mass spectral data elucidated the structures of the all newly synthesized compounds. In vitro antimicrobial activities of the synthesized compounds were investigated against Gram-positive Bacillus subtilis, Gram-negative Escherichia coli and fungi Candida albicans and Aspergillus niger. Some of the tested compounds showed significant antimicrobial activity. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.12.013

文献信息

• Synthesis, in vitro antibacterial and antifungal evaluations of new α-hydroxyphosphonate and new α-acetoxyphosphonate derivatives of tetrazolo [1, 5-a] quinoline
  作者：Amol H. Kategaonkar、Rajkumar U. Pokalwar、Swapnil S. Sonar、Vaibhav U. Gawali、Bapurao B. Shingate、Murlidhar S. Shingare

  DOI：10.1016/j.ejmech.2009.12.013

  日期：2010.3

  A series of new alpha-hydroxyphosphonate and alpha-acetoxyphosphonate derivatives have been synthesized for the first time of tetrazolo [1, 5-a] quinoline derivatives. Elemental analysis, IR, H-1 NMR, C-13 NMR and mass spectral data elucidated the structures of the all newly synthesized compounds. In vitro antimicrobial activities of the synthesized compounds were investigated against Gram-positive Bacillus subtilis, Gram-negative Escherichia coli and fungi Candida albicans and Aspergillus niger. Some of the tested compounds showed significant antimicrobial activity. (C) 2009 Elsevier Masson SAS. All rights reserved.