NPSR-QA1 | 1226997-30-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: NPSR-QA1
• 英文别名: N-(1-ethyl-1-methyl-3-morpholin-4-ylpropyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide；N-(3-methyl-1-morpholin-4-ylpentan-3-yl)-N-[(1-methyl-2-oxoquinolin-3-yl)methyl]cyclohexanecarboxamide
• CAS: 1226997-30-3
• 化学式: C₂₈H₄₁N₃O₃
• 分子量: 467.652
• InChiKey: FWHNGUFKFXDMER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  53.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  NPSR-QA1 生成 、
  参考文献：
  名称：

  Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists

  摘要：

  Administration of Neuropeptide S (NPS) has been shown to produce arousal, that is, independent of novelty and to induce wakefulness by suppressing all stages of sleep, as demonstrated by EEG recordings in rat. Medicinal chemistry efforts have identified a quinolinone class of potent NPSR antagonists that readily cross the blood-brain barrier. We detail here optimization efforts resulting in the identification of a potent NPSR antagonist which dose-dependently and specifically inhibited (125)I-NPS binding in the CNS when administered to rats. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.143
• 作为产物：
  描述：

  吗啉 、 N-(3-methyl-1-oxopentan-3-yl)-N-[(1-methyl-2-oxoquinolin-3-yl)methyl]cyclohexanecarboxamide 在 sodium acetate 、 三乙酰氧基硼氢化钠 作用下， 以 溶剂黄146 为溶剂， 生成 NPSR-QA1
  参考文献：
  名称：

  Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists

  摘要：

  Administration of Neuropeptide S (NPS) has been shown to produce arousal, that is, independent of novelty and to induce wakefulness by suppressing all stages of sleep, as demonstrated by EEG recordings in rat. Medicinal chemistry efforts have identified a quinolinone class of potent NPSR antagonists that readily cross the blood-brain barrier. We detail here optimization efforts resulting in the identification of a potent NPSR antagonist which dose-dependently and specifically inhibited (125)I-NPS binding in the CNS when administered to rats. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.143

文献信息

• Quinolone Neuropeptide S Receptor Antagonists
  申请人：Barrow James C.

  公开号：US20110212946A1

  公开（公告）日：2011-09-01

  The present invention is directed to quinolone compounds which are antagonists of neuropeptide S receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which the neuropeptide S receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the neuropeptide S receptor is involved.

  本发明涉及喹诺酮化合物，它们是神经肽S受体拮抗剂，可用于治疗或预防神经系统和精神疾病，以及涉及神经肽S受体的疾病。本发明还涉及包含这些化合物的制药组合物，以及这些化合物和组合物在预防或治疗涉及神经肽S受体的疾病中的用途。
• US8389720B2
  申请人：——

  公开号：US8389720B2

  公开（公告）日：2013-03-05
• Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists
  作者：Jeffrey Y. Melamed、Amy E. Zartman、Nathan R. Kett、Anthony L. Gotter、Victor N. Uebele、Duane R. Reiss、Cindra L. Condra、Christine Fandozzi、Laura S. Lubbers、Blake A. Rowe、Georgia B. McGaughey、Martin Henault、Rino Stocco、John J. Renger、George D. Hartman、Mark T. Bilodeau、B. Wesley Trotter

  DOI：10.1016/j.bmcl.2010.04.143

  日期：2010.8

  Administration of Neuropeptide S (NPS) has been shown to produce arousal, that is, independent of novelty and to induce wakefulness by suppressing all stages of sleep, as demonstrated by EEG recordings in rat. Medicinal chemistry efforts have identified a quinolinone class of potent NPSR antagonists that readily cross the blood-brain barrier. We detail here optimization efforts resulting in the identification of a potent NPSR antagonist which dose-dependently and specifically inhibited (125)I-NPS binding in the CNS when administered to rats. (C) 2010 Elsevier Ltd. All rights reserved.