(R)-1-(5-(2,2,2-三氟乙氧基)吡啶-2-基)乙胺 | 953780-33-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: (R)-1-(5-(2,2,2-三氟乙氧基)吡啶-2-基)乙胺
• 英文名称: (R)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2 yl]ethan-1-amine
• 英文别名: (r)-1-(5-(2,2,2-Trifluoroethoxy)pyridin-2-yl)ethanamine；(1R)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethanamine
• CAS: 953780-33-1
• 化学式: C₉H₁₁F₃N₂O
• 分子量: 220.194
• InChiKey: GWMLEFYJEKOQMC-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  48.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (R)-1-(5-(2,2,2-三氟乙氧基)吡啶-2-基)乙胺 、 草酸 以 乙酸乙酯 为溶剂， 以5.15 kg的产率得到
  参考文献：
  名称：

  T 型钙通道拮抗剂 MK-8998 的可扩展不对称合成

  摘要：

  从简单的吡啶构建块开发了两种用于合成 T 型钙通道拮抗剂 MK-8998 的可扩展且有效的合成路线。设置立体化学的关键步骤依赖于手性铑催化剂介导的烯酰胺不对称氢化或芳基酮的氨基转移，从而以高对映选择性和高产率提供相应的产物。

  DOI：

  10.1021/acs.joc.1c01795
• 作为产物：
  描述：

  在 potassium hydroxide 作用下， 以 甲基叔丁基醚 为溶剂， 以3.77 kg的产率得到(R)-1-(5-(2,2,2-三氟乙氧基)吡啶-2-基)乙胺
  参考文献：
  名称：

  T 型钙通道拮抗剂 MK-8998 的可扩展不对称合成

  摘要：

  从简单的吡啶构建块开发了两种用于合成 T 型钙通道拮抗剂 MK-8998 的可扩展且有效的合成路线。设置立体化学的关键步骤依赖于手性铑催化剂介导的烯酰胺不对称氢化或芳基酮的氨基转移，从而以高对映选择性和高产率提供相应的产物。

  DOI：

  10.1021/acs.joc.1c01795

文献信息

• Palladium-Catalyzed Carbon Isotope Exchange on Aliphatic and Benzoic Acid Chlorides
  作者：Donald R. Gauthier、Nelo R. Rivera、Haifeng Yang、Danielle M. Schultz、C. Scott Shultz

  DOI：10.1021/jacs.8b09808

  日期：2018.11.21

  An operationally simple protocol for a palladium-catalyzed 13CO and 14CO exchange with activated aliphatic and benzoic carbonyls is presented. Several 13C and 14C building blocks, natural product derivatives, and pharmaceuticals have been prepared to showcase the method for late-stage carbon isotope incorporation and its functional group compatibility.

  提出了一种操作简单的钯催化 13CO 和 14CO 与活化脂肪族和苯甲羰基交换的协议。已经制备了几种 13C 和 14C 构建块、天然产物衍生物和药物，以展示后期碳同位素掺入的方法及其官能团兼容性。
• [EN] ARYL SUBSTITUTED CARBOXAMIDE DERIVATIVES AS CALCIUM OR SODIUM CHANNEL BLOCKERS<br/>[FR] DÉRIVÉS DE CARBOXAMIDE SUBSTITUÉS PAR ARYLE COMME INHIBITEURS DES CANAUX CALCIQUES OU SODIQUES
  申请人：RAQUALIA PHARMA INC

  公开号：WO2010137351A1

  公开（公告）日：2010-12-02

  The present invention relates to aryl substituted carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, which have blocking activities of T-type calcium channels or voltage gated sodium channels as the tetrodotoxin-sensitive (TTX-S)blockers such as NaV1.3 and NaV1.7, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels or voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels or voltage gated sodium channels are involved.

  本发明涉及式(I)或其药物可接受的盐的芳基取代羧酰胺衍生物，其具有T型钙通道或电压门控钠通道的阻断活性，如NaV1.3和NaV1.7等Tetrodotoxin敏感（TTX-S）阻断剂，适用于治疗或预防涉及T型钙通道或电压门控钠通道的疾病和紊乱。本发明还涉及包含这些化合物的药物组合物以及在预防或治疗涉及T型钙通道或电压门控钠通道的疾病中使用这些化合物和组合物的用途。
• Pyridyl Amide T-Type Calcium Channel Antagonists
  申请人：Barrow James C.

  公开号：US20090275550A1

  公开（公告）日：2009-11-05

  The present invention is directed to pyridyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

  本发明涉及对T型钙通道具有拮抗作用的吡啶酰胺化合物，其在治疗或预防与T型钙通道有关的疾病和疾病中具有用途。本发明还涉及包含这些化合物的制药组合物以及使用这些化合物和组合物预防或治疗与T型钙通道有关的疾病的用途。
• HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS
  申请人：Barrow James C.

  公开号：US20100249176A1

  公开（公告）日：2010-09-30

  The present invention is directed to heterocycle amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

  本发明涉及杂环酰胺化合物，其是T型钙通道的拮抗剂，并且在治疗或预防涉及T型钙通道的疾病和疾病方面具有用途。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗涉及T型钙通道的疾病方面使用这些化合物和组合物。
• HETEROCYCLE PHENYL AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS
  申请人：Barrow James C.

  公开号：US20100261724A1

  公开（公告）日：2010-10-14

  The present invention is directed to heterocycle phenyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

  本发明涉及杂环苯酰胺化合物，其为T型钙通道的拮抗剂，可用于治疗或预防涉及T型钙通道的疾病和疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及T型钙通道的疾病中的使用。