6-Bromo-5-methoxy-2-propan-2-yloxy-4-(trifluoromethyl)quinoline | 1041642-81-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-Bromo-5-methoxy-2-propan-2-yloxy-4-(trifluoromethyl)quinoline
• CAS: 1041642-81-2
• 化学式: C₁₄H₁₃BrF₃NO₂
• 分子量: 364.162
• InChiKey: NMYOFNRXQHITPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  6-Bromo-5-methoxy-2-propan-2-yloxy-4-(trifluoromethyl)quinoline 、 2-(N,N-二乙基甲酰氨)苯基硼酸 在 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 生成
  参考文献：
  名称：

  Discovery of a novel series of nonsteroidal androgen receptor modulators: 5- or 6-oxachrysen-2-ones

  摘要：

  A novel oxachrysenone series (2) of nonsteroidal selective androgen receptor modulators (SARM) was developed based on the 6-aryl-2-quinolinones (1). Synthesis and preliminary SAR results based on in vitro assays are discussed. In the cotransfection assay, lead compound 5d showed AR agonist activity more potent than dihydrotestosterone (DHT), whereas compound 17b was a potent antagonist similar to bicalutamide. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.03.085
• 作为产物：
  描述：

  2-碘代丙烷 、 6-bromo-5-methoxy-4-(trifluoromethyl)-1H-quinolin-2-one 在 cesium fluoride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 17.0h， 生成 6-Bromo-5-methoxy-2-propan-2-yloxy-4-(trifluoromethyl)quinoline
  参考文献：
  名称：

  WO2007/75884

  摘要：

  公开号：

文献信息

• WO2007/75884
  申请人：——

  公开号：——

  公开（公告）日：——
• Androgen Receptor Modulator Compounds and Methods
  申请人：Van Oeveren Cornelis Arjan

  公开号：US20090203725A1

  公开（公告）日：2009-08-13

  Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors and/or modulate the amount of androgen receptors; and to methods for making and using such compounds. Also provided are compositions containing such compounds and methods for making and using such compositions.
• Discovery of a novel series of nonsteroidal androgen receptor modulators: 5- or 6-oxachrysen-2-ones
  作者：Shuo Zhao、Yixing Shen、Arjan van Oeveren、Keith B. Marschke、Lin Zhi

  DOI：10.1016/j.bmcl.2008.03.085

  日期：2008.6

  A novel oxachrysenone series (2) of nonsteroidal selective androgen receptor modulators (SARM) was developed based on the 6-aryl-2-quinolinones (1). Synthesis and preliminary SAR results based on in vitro assays are discussed. In the cotransfection assay, lead compound 5d showed AR agonist activity more potent than dihydrotestosterone (DHT), whereas compound 17b was a potent antagonist similar to bicalutamide. (c) 2008 Elsevier Ltd. All rights reserved.