(E)-1-(1,1-二甲基乙氧基)-3,7-二甲基辛-2,6-二烯 | 63343-23-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: (E)-1-(1,1-二甲基乙氧基)-3,7-二甲基辛-2,6-二烯
• 英文名称: t-butylate de geranyle
• 英文别名: (E)-1-(1,1-dimethylethoxy)-3,7-dimethylocta-2,6-diene；(2E)-3,7-dimethyl-1-[(2-methylpropan-2-yl)oxy]octa-2,6-diene
• CAS: 63343-23-7
• 化学式: C₁₄H₂₆O
• 分子量: 210.36
• InChiKey: OSIVVAJCXDMLCS-JLHYYAGUSA-N

物化性质

• 沸点：
  268.3±19.0 °C(Predicted)
• 密度：
  0.831±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (E)-1-(1,1-二甲基乙氧基)-3,7-二甲基辛-2,6-二烯 生成 (1S,2S,4R)-2-tert-Butoxymethyl-1,3,3-trimethyl-7-oxa-bicyclo[2.2.1]heptane
  参考文献：
  名称：

  Syntheses de la (+)-marmine, des (+)-epoxy-6′,7′- et (-)-epoxy-3′,6′-auraptenes et des racemiques correspondants.

  摘要：

  DOI：

  10.1016/s0040-4039(00)96152-5

文献信息

• NOVEL SUGAR-DERIVED GELATOR
  申请人：KYUSHU UNIVERSITY

  公开号：US20150025157A1

  公开（公告）日：2015-01-22

  There is provided a novel gelator containing a sugar derivative. A gelator including a compound of Formula (1) or Formula (2): wherein each of R 1 and R 3 is independently a linear or branched alkyl group having a carbon atom number of 1 to 20, a cyclic C 3-20 alkyl group, or a linear or branched alkenyl group having a carbon atom number of 2 to 20, n is 0 or an integer of 1 to 4, R 2 is a hydrogen atom, a linear or branched alkyl group having a carbon atom number of 1 to 10, or an aryl group optionally having a substituent, and R 4 and R 5 are each a hydroxy group.

  提供一种含有糖衍生物的新型凝胶剂。包括化合物Formula（1）或Formula（2）的凝胶剂：其中R1和R3中的每一个独立地是具有1到20个碳原子数的线性或支链烷基基团，具有3-20个碳原子的环状烷基基团，或具有2到20个碳原子数的线性或支链烯基基团，n为0或1到4的整数，R2是氢原子，具有1到10个碳原子数的线性或支链烷基基团，或具有取代基的芳基，R4和R5各自是一个羟基。
• IONIZABLE LIPIDS AND METHODS OF MANUFACTURE AND USE THEREOF
  申请人：George Mason Research Foundation, Inc.

  公开号：US20220218622A1

  公开（公告）日：2022-07-14

  The invention encompasses novel ionizable lipids compounds and their use in lipid nanoparticles delivery systems that are useful in the delivery of nucleic acids to a mammalian subject that can be included for use, for example, as cancer vaccines, gene editing therapeutics, delivery of nucleic acid (e.g., mRNA) encoding antibodies, vaccines for infectious disease, and protein replacement therapeutics. Additionally, the invention encompasses compositions and therapeutics comprising the ionizable lipids in the lipid nanoparticles and the use of the composition and therapeutics for the preparation of a pharmaceutical composition, especially a vaccine, (e.g., for use in the prophylaxis or treatment of infectious diseases, tumor or cancer diseases, rare diseases, allergies, or autoimmune diseases). The invention encompasses methods of treatment or prophylaxis of the aforementioned diseases.
• US9278989B2
  申请人：——

  公开号：US9278989B2

  公开（公告）日：2016-03-08
• Syntheses de la (+)-marmine, des (+)-epoxy-6′,7′- et (-)-epoxy-3′,6′-auraptenes et des racemiques correspondants.
  作者：Mostafa Aziz、Francis Rouessac

  DOI：10.1016/s0040-4039(00)96152-5

  日期：1987.1