1-(4-Chloro-phenyl)-3-(2-methyl-quinolin-4-yl)-urea | 71070-82-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(4-Chloro-phenyl)-3-(2-methyl-quinolin-4-yl)-urea
• 英文别名: 1-(4-Chlorophenyl)-3-(2-methylquinolin-4-yl)urea
• CAS: 71070-82-1
• 化学式: C₁₇H₁₄ClN₃O
• 分子量: 311.771
• InChiKey: JQMQNDGGSXZDNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  54
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-氨基喹哪啶 、 对氯苯异氰酸酯 以 二甲基亚砜 为溶剂， 生成 1-(4-Chloro-phenyl)-3-(2-methyl-quinolin-4-yl)-urea
  参考文献：
  名称：

  Evaluation of Diarylureas for Activity Against Plasmodium falciparum

  摘要：

  A library of diarylurea insulin-like growth factor 1 receptor inhibitors was screened for activity against chloroquine-sensitive (3D7) and chloroquine-resistant (K1) strains of Plasmodium falciparum. The 4-aminoquinaldine-derived diarylureas displayed promising antimalarial potency. Further exploration of the B ring of 4-aminoquinaldinyl ureas allowed identification of several quinaldin-4-yl ureas 4{13, 39} and 4{13, 58) sufficiently potent against both 3D7 and K1 strains to qualify as bone fide leads.

  DOI：

  10.1021/ml100083c

文献信息

• PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1150977A1

  公开（公告）日：2001-11-07
• US6699879B1
  申请人：——

  公开号：US6699879B1

  公开（公告）日：2004-03-02
• [EN] PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS<br/>[FR] DERIVES DE PHENYLUREE ET DE PHENYLTHIOUREE UTILISES COMME ANTAGONISTES DES RECEPTEURS DE L'OREXINE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2000047577A1

  公开（公告）日：2000-08-17

  The present invention provides phenyl urea and phenyl thiourea derivatives which are non-peptide antagonists of human orexin receptors, in particular orexin-1 receptors, of formula (I) in which: Z represents oxygen or sulfur; and R1 to R7 represent various substituent groups; and pharmaceutically acceptable salts thereof. In particular, these compounds are of potential use in the treatment of obesity including obesity observed in Type 2(non-insulin-dependent) diabetes patients and/or sleep disorders.
• Evaluation of Diarylureas for Activity Against <i>Plasmodium falciparum</i>
  作者：Yiqun Zhang、Marc Anderson、Jennifer L. Weisman、Min Lu、Cindy J. Choy、Vincent A. Boyd、Jeanine Price、Martina Sigal、Julie Clark、Michele Connelly、Fangyi Zhu、W. Armand Guiguemde、Cynthia Jeffries、Lei Yang、Andrew Lemoff、Ally P. Liou、Thomas R. Webb、Joseph L. DeRisi、R. Kiplin Guy

  DOI：10.1021/ml100083c

  日期：2010.12.9

  A library of diarylurea insulin-like growth factor 1 receptor inhibitors was screened for activity against chloroquine-sensitive (3D7) and chloroquine-resistant (K1) strains of Plasmodium falciparum. The 4-aminoquinaldine-derived diarylureas displayed promising antimalarial potency. Further exploration of the B ring of 4-aminoquinaldinyl ureas allowed identification of several quinaldin-4-yl ureas 413, 39} and 413, 58) sufficiently potent against both 3D7 and K1 strains to qualify as bone fide leads.