methyl 2-vinylthiazole-4-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: methyl 2-vinylthiazole-4-carboxylate
• 英文别名: Methyl 2-ethenyl-1,3-thiazole-4-carboxylate；methyl 2-ethenyl-1,3-thiazole-4-carboxylate
• 化学式: C₇H₇NO₂S
• 分子量: 169.204
• InChiKey: CSRGPBIMVKZPHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  67.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 2-vinylthiazole-4-carboxylate 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 、 水 为溶剂， 25.0 ℃ 、103.42 kPa 条件下， 以87 %的产率得到Methyl 2-ethylthiazole-4-carboxylate
  参考文献：
  名称：

  [EN] SUBSTITUTED 3,4-DIHYDROISOQUINOLIN-1(2H)-ONE DERIVATIVES AND RELATED USES
  [FR] DÉRIVÉS DE 3,4-DIHYDROISOQUINOLIN-1(2H)-ONE SUBSTITUÉS ET UTILISATIONS ASSOCIÉES

  摘要：

  The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

  公开号：

  WO2023240134A1
• 作为产物：
  描述：

  乙烯基硼酸频哪醇酯 、 2-溴噻唑-4-羧酸甲酯 在 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 四氢呋喃 、 水 为溶剂， 以89 %的产率得到methyl 2-vinylthiazole-4-carboxylate
  参考文献：
  名称：

  [EN] SUBSTITUTED 3,4-DIHYDROISOQUINOLIN-1(2H)-ONE DERIVATIVES AND RELATED USES
  [FR] DÉRIVÉS DE 3,4-DIHYDROISOQUINOLIN-1(2H)-ONE SUBSTITUÉS ET UTILISATIONS ASSOCIÉES

  摘要：

  The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

  公开号：

  WO2023240134A1

文献信息

• NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：Cornerstone Therapeutics Inc.

  公开号：EP2044038B1

  公开（公告）日：2014-07-02
• [EN] SUBSTITUTED 3,4-DIHYDROISOQUINOLIN-1(2H)-ONE DERIVATIVES AND RELATED USES<br/>[FR] DÉRIVÉS DE 3,4-DIHYDROISOQUINOLIN-1(2H)-ONE SUBSTITUÉS ET UTILISATIONS ASSOCIÉES
  申请人：[en]NODTHERA LIMITED

  公开号：WO2023240134A1

  公开（公告）日：2023-12-14

  The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.