S-2-(4-吡啶基乙基)-L-半胱氨酸 | 28809-04-3

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 半胱氨酸类衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: S-2-(4-吡啶基乙基)-L-半胱氨酸
• 中文别名: S-(2-吡啶-4-乙基)半胱氨酸；S-β-(4-吡啶乙基)-L-半胱氨酸
• 英文名称: S-β-(4-Pyridyl-ethyl)-L-cystein
• 英文别名: L-S-[2-(4-Pyridyl)ethyl]-Cysteine；(2R)-2-azaniumyl-3-(2-pyridin-4-ylethylsulfanyl)propanoate
• CAS: 28809-04-3
• 化学式: C₁₀H₁₄N₂O₂S
• mdl: MFCD00038044
• 分子量: 226.299
• InChiKey: OBAZTSDKFIRVPD-VIFPVBQESA-N

物化性质

• 熔点：
  212-214 °C (dec.)
• 沸点：
  442.4±45.0 °C(Predicted)
• 密度：
  1.273±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 危险等级：
  IRRITANT
• 安全说明：
  S22,S24/25
• WGK Germany：
  3
• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  S-2-(4-吡啶基乙基)-L-半胱氨酸 、 二碳酸二叔丁酯 在 sodium carbonate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 以41%的产率得到Boc-Cys(Pye)
  参考文献：
  名称：

  Solid-phase synthesis of O-palmitoylated peptides

  摘要：

  Solid-phase synthesis of an O-palmitoylated peptide has been achieved by either palmitoylation of the resin-bound peptide or synthesis of palmitoylated Fmoc-Thr and subsequent solid-phase incorporation. The desired peptides containing palmitoylated Thr were isolated by reversed-phase C18 HPLC. An O --> N acyl shift was encountered when palmitoylated Fmoc-Thr was utilized.

  DOI：

  10.1016/s0040-4039(00)74037-8

文献信息

• [EN] THIOSEMICARBAZATES AND USES THEREOF<br/>[FR] THIOSEMICARBAZATES ET LEURS UTILISATIONS
  申请人：FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH

  公开号：WO2020227592A1

  公开（公告）日：2020-11-12

  Thioesters, thiocarbamates, thiocarbazates, semithiocarbazates, peptides, aza-amino acid conjugates, and azapeptides; and a chemoselective and site-specific functionalization protocol of protected thiocarbazates and semithiocarbazates are described. The protocol features the use of Mitsunobu reaction to alkylate specifically the nitrogen atom close to the acylthiol moiety with alcohols to produce protected mono-substituted thiocarbazates that can be stored for months, activated under mild conditions at low temperature using halonium reagents and integrated orthogonally to make substituted semicarbazides that can be used, e.g., as synthons in synthesis of aza-amino acid conjugates, azapeptides and other peptidomimetics. Methods for preparing and using ureases, carbazides, semicarbazides, beta-peptides, azapeptides, and other peptidomimetics and azapeptide conjugates, and uses of ureases, carbazides, semicarbazides, beta-peptides, azapeptides in drug discovery, diagnosis, inhibition, prevention and treatment of diseases are also described.

  巯酯，硫代氨基甲酸酯，硫代氨基甲酸酯，半硫代氨基甲酸酯，肽，氮代氨基酸共轭物和氮代肽；以及一种对受保护的硫代氨基甲酸酯和半硫代氨基甲酸酯进行化学选择性和位点特异性功能化的方法被描述。该方法采用三甲基脲反应特异性烷基化靠近酰硫醇基团的氮原子，使用醇生成可储存数月的受保护的单取代硫代氨基甲酸酯，在低温下使用卤化物试剂轻微条件下激活，并与其他基团正交集成以制备取代半氨基甲酸酰胺，例如，可用作氮代氨基酸共轭物，氮代肽和其他肽类模拟物的合成中间体。还描述了制备和使用尿酶，卡巴酰胺，半氨基甲酸酰胺，β-肽，氮代肽和其他肽类模拟物以及氮代肽共轭物的方法，以及尿酶，卡巴酰胺，半氨基甲酸酰胺，β-肽，氮代肽在药物发现，诊断，抑制，预防和治疗疾病中的用途。
• [EN] COMPOUNDS FOR USE IN SYNTHESIS OF PEPTIDOMIMETICS<br/>[FR] COMPOSÉS DESTINÉS À ÊTRE UTILISÉS DANS LA SYNTHÈSE DE PEPTIDOMIMÉTIQUES
  申请人：FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH

  公开号：WO2020227594A1

  公开（公告）日：2020-11-12

  Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.

  本文介绍了O-苯并三唑和O-咪唑合成物的合成方法。这些合成物可用于合成氮杂肽和其他肽类模拟物，同时也介绍了从这些合成物合成氮杂肽和其他肽类模拟物的方法，以及氮杂肽和其他肽类模拟物的用途。
• pH dependent ion exchange matrix and method of use in the isolation of nucleic acids
  申请人：Promega Corporation

  公开号：US20010014650A1

  公开（公告）日：2001-08-16

  pH dependent ion exchange matrices are provided, with methods for making such matrices, and methods for using such matrices to isolate a target nucleic acid, such as plasmid DNA, chromosomal DNA, or RNA from contaminants, including proteins, lipids, cellular debris, or other nucleic acids. Each pH dependent ion exchange matrix of this invention comprises at least two different ion exchange functional groups, one of which is capable of acting as an anion exchanger at a first pH, and the other of which is capable of acting as a cation exchanger at a second, higher pH. The matrix has an overall neutral charge in a pH range between the first and second pH. The pH dependent ion exchange matrices of the present invention are designed to bind to the target nucleic acid at a pH wherein the overall charge of the matrix is positive, and to release the target nucleic acid as the pH of the surrounding solution is increased. The target nucleic acid can be released from the pH dependent matrix in little or no salt and at about a neutral pH. The matrices and methods of this invention enable one to isolate a target nucleic acid in very few steps, without the use of hazardous chemicals. Target nucleic acids isolated using the pH dependent ion exchange matrices according to the present invention can be used immediately without further extraction or isolation.

  提供了pH依赖的离子交换基质，包括制备这种基质的方法以及使用这种基质从污染物中分离目标核酸（如质粒DNA、染色体DNA或RNA）的方法，其中污染物包括蛋白质、脂质、细胞碎片或其他核酸。本发明的每个pH依赖的离子交换基质至少包含两种不同的离子交换功能基团，其中一种在第一个pH下能够作为阴离子交换剂，另一种在第二个更高的pH下能够作为阳离子交换剂。该基质在第一个和第二个pH之间的pH范围内具有总体中性电荷。本发明的pH依赖的离子交换基质被设计成在基质总体电荷为正的pH下结合目标核酸，并随着周围溶液的pH升高释放目标核酸。目标核酸可以在几乎没有盐和中性pH下从pH依赖的基质中释放出来。本发明的基质和方法使得在很少的步骤中分离目标核酸成为可能，而不需要使用危险化学品。使用本发明的pH依赖的离子交换基质分离的目标核酸可以立即使用，无需进一步提取或分离。
• Compositions for use in golf balls
  申请人：Bulpett A. David

  公开号：US20050245652A1

  公开（公告）日：2005-11-03

  A golf ball comprises a core, an outer cover layer, and, optionally, an intermediate layer disposed between the core and the outer cover layer. The outer cover layer may comprise a polyurethane or polyurea composition. At least one portion of the golf ball comprises a composition that enhances physical properties and/or performance characteristics (e.g., coefficient of restitution) of the golf ball. Preferably, the coefficient of restitution of the core is 0.8 or greater.

  高尔夫球由内核、外覆盖层和可选的中间层组成，外覆盖层可以包括聚氨酯或聚脲组成。高尔夫球的至少一部分包含一种增强物理特性和/或性能特征（例如反弹系数）的组合物。最好，内核的反弹系数为0.8或更高。
• COMPOSITIONS FOR USE IN GOLF BALLS
  申请人：Sullivan Michael J.

  公开号：US20080227567A1

  公开（公告）日：2008-09-18

  A golf ball comprises a core, an outer cover layer, and, optionally, an intermediate layer disposed between the core and the outer cover layer. The outer cover layer may comprise a polyurethane or polyurea composition. At least one portion of the golf ball comprises a composition that enhances physical properties and/or performance characteristics (e.g., coefficient of restitution) of the golf ball. Preferably, the coefficient of restitution of the core is 0.8 or greater.

  一个高尔夫球包括一个核心、一个外覆盖层，以及可选的介质层，介质层位于核心和外覆盖层之间。外覆盖层可能包括聚氨酯或聚脲组成。高尔夫球的至少一部分包含一种增强高尔夫球物理性能和/或性能特征（例如反弹系数）的组成。最好，核心的反弹系数为0.8或更高。