Quinolin-3-yl-[1-p-tolyl-meth-(E)-ylidene]-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Quinolin-3-yl-[1-p-tolyl-meth-(E)-ylidene]-amine
• 英文别名: 1-(p-tolyl)-N-(3-quinolyl)methanimine；1-(4-methylphenyl)-N-quinolin-3-ylmethanimine
• 化学式: C₁₇H₁₄N₂
• 分子量: 246.312
• InChiKey: RCQPNCMESVOGPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  25.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Quinolin-3-yl-[1-p-tolyl-meth-(E)-ylidene]-amine 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 (4-Methyl-benzyl)-quinolin-3-yl-amine
  参考文献：
  名称：

  Design, synthesis and antimycotic activity of (N-heteroaryl)arylmethanamines

  摘要：

  DOI：

  10.1002/(sici)1099-1395(199602)9:2<61::aid-poc748>3.0.co;2-r
• 作为产物：
  描述：

  3-氨基喹啉 、 对甲基苯甲醛 在 溶剂黄146 作用下， 以 乙醇 、 苯 为溶剂， 反应 24.0h， 以65%的产率得到Quinolin-3-yl-[1-p-tolyl-meth-(E)-ylidene]-amine
  参考文献：
  名称：

  Election Impact Mass Spectra of para-Substituted N-Heteroaryl Benzylamines

  摘要：

  The 70 eV electron impact mass spectra of some para-substituted N-heteroaryl benzylamines, synthesized through the corresponding Schiff bases, are reported. Typical fragmentation patterns are discussed with the aid of mass analyzed ion kinetic energy spectra and exact mass measurements. The compounds are relatively stable under electron impact, the molecular ion being the base peak or the second most intense ion in the spectra. The dominating breakdown process is the benzylic cleavage, that gives rise to the base peak in some of the investigated compounds and to the second intense peak in others.

  DOI：

  10.3987/com-93-s16

文献信息

• Research on antibacterial and antifungal agents. XI. Synthesis and antimicrobial activity of N-heteroaryl benzylamines and their Schiff bases
  作者：R Fioravanti、M Biava、GC Porretta、C Landolfi、N Simonetti、A Villa、E Conte、A Porta-Puglia

  DOI：10.1016/0223-5234(96)88217-1

  日期：1995.1

  The synthesis and antimicrobial activity of new N-heteroaryl benzylamines and their Schiff bases are reported. Antifungal data were compared with those obtained with miconazole ketoconazole, enilconazole and imazalil sulfate; which showed that some of the tested compounds possessed moderate activity against strains of Candida albicans, Candida sp and good activity against isolates of plant pathogenic fungi, In contrast the synthesized compounds showed poor antibacterial activity, except for 3j which exhibited a better activity than nalidixic acid used as positive control. The results obtained are discussed on the basis of structure-activity relationships.
• Election Impact Mass Spectra of para-Substituted N-Heteroaryl Benzylamines
  作者：Rossella Fioravanti、Mariangela Biava、Giulio Cesare Porretta、Salvatore Foti、Giuseppe Musumarra、Rosaria Saletti

  DOI：10.3987/com-93-s16

  日期：——

  The 70 eV electron impact mass spectra of some para-substituted N-heteroaryl benzylamines, synthesized through the corresponding Schiff bases, are reported. Typical fragmentation patterns are discussed with the aid of mass analyzed ion kinetic energy spectra and exact mass measurements. The compounds are relatively stable under electron impact, the molecular ion being the base peak or the second most intense ion in the spectra. The dominating breakdown process is the benzylic cleavage, that gives rise to the base peak in some of the investigated compounds and to the second intense peak in others.
• Design, synthesis and antimycotic activity of (N-heteroaryl)arylmethanamines
  作者：Alberto Ballistreri、Alessandra Bottino、Giuseppe Musumarra、Rossella Fioravanti、Mariangela Biava、Giulio Cesare Porretta、Nicola Simonetti、Adelaide Villa

  DOI：10.1002/(sici)1099-1395(199602)9:2<61::aid-poc748>3.0.co;2-r

  日期：1996.2