N-乙酰基-L-苯丙氨酰基-3,5-二碘-L-酪氨酸 | 3786-08-1

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 酪氨酸类衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-乙酰基-L-苯丙氨酰基-3,5-二碘-L-酪氨酸
• 英文名称: Ac-Phe-3,5-di-iodo-Tyr
• 英文别名: Acetyl-L-phenylalanyl-L-di-jod-tyrosin；N-(N-acetyl-L-phenylalanyl)-3,5-diiodo-L-tyrosine；N-(N-Acetyl-L-phenylalanyl)-3,5-dijod-L-tyrosin；N-Acetyl-L-phenylalanyl-3,5-diiodo-L-tyrosine；(2S)-2-[[(2S)-2-acetamido-3-phenylpropanoyl]amino]-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid
• CAS: 3786-08-1
• 化学式: C₂₀H₂₀I₂N₂O₅
• 分子量: 622.198
• InChiKey: DWIHCEZUWCRUES-IRXDYDNUSA-N

物化性质

• 熔点：
  219-221 °C
• 密度：
  1.7870 (estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  5

安全信息

• 安全说明：
  S24/25
• WGK Germany：
  3
• 海关编码：
  29241900

反应信息

• 作为产物：
  描述：

  N-乙酰基-L-苯丙氨酰-L-酪氨酸 在 ammonium hydroxide 作用下， 生成 N-乙酰基-L-苯丙氨酰基-3,5-二碘-L-酪氨酸
  参考文献：
  名称：

  Baker, Journal of Biological Chemistry, 1951, vol. 193, p. 809,815

  摘要：

  DOI：

文献信息

• METHOD AND APPARATUS FOR MEASURING ENVIRONMENTAL ALLERGEN
  申请人：Japan Science and Technology Agency

  公开号：EP1712637A1

  公开（公告）日：2006-10-18

  A method for measuring an environmental allergen by which the allergen may be measured simply without using an anti-allergen antibody, as well as an instrument and apparatus therefor, is disclosed. In the method for measuring the environmental biological allergen, the biological allergen is measured by measuring the protease activity of the allergen. An instrument for measuring an environmental allergen(s) comprises a support and the substrate of the protease carried on the support, which substrate is used for the measurement of the protease activity of the allergen(s). The substrate is one which brings about fluorescence emission or change in absorption as a result of the enzyme reaction.

  本发明公开了一种测量环境过敏原的方法，通过这种方法可以不使用抗过敏原抗体而简单地测量过敏原，同时还公开了一种仪器和装置。在测量环境生物过敏原的方法中，通过测量过敏原的蛋白酶活性来测量生物过敏原。测量环境过敏原的仪器包括支架和支架上携带的蛋白酶底物，该底物用于测量过敏原的蛋白酶活性。底物是一种能在酶反应过程中产生荧光发射或吸收变化的物质。
• Multi-analyte diagnostic test for thyroid disorders
  申请人：Bio-Rad Laboratories, Inc.

  公开号：US20030054571A1

  公开（公告）日：2003-03-20

  Immunological assays for several biological markers for thyroid disorders in a biological sample are performed in a single test with a combination of sandwich-type, sequential competitive, and serological assays by the use of particles classified into groups that are distinguishable by flow cytometry, one group for the assay of each marker. Each group of particles is coated with a different immunological binding member, and coating densities, co-coating materials, and special buffer solutions are used to adjust for differences in the sensitivities and dynamic ranges of each of the markers in the typical sample.

  对生物样本中甲状腺疾病的几种生物标记物进行免疫测定，可在一次试验中结合使用夹心式、顺序竞争式和血清学测定法，方法是使用可通过流式细胞仪区分的颗粒分组，每种标记物一组。每组微粒都涂有不同的免疫结合剂，涂布密度、共涂材料和特殊的缓冲溶液用于调整典型样本中每种标记物的敏感性和动态范围的差异。
• MULTI-ANALYTE DIAGNOSTIC TEST FOR THYROID DISORDERS
  申请人：BIO-RAD LABORATORIES, INC.

  公开号：EP1272855A2

  公开（公告）日：2003-01-08
• Method and Apparatus for Measuring Enviromental Allergen
  申请人：Honda Aki

  公开号：US20080050764A1

  公开（公告）日：2008-02-28

  A method for measuring an environmental allergen by which the allergen may be measured simply without using an anti-allergen antibody, as well as an instrument and apparatus therefor, is disclosed. In the method for measuring the environmental biological allergen, the biological allergen is measured by measuring the protease activity of the allergen. An instrument for measuring an environmental allergen(s) comprises a support and the substrate of the protease carried on the support, which substrate is used for the measurement of the protease activity of the allergen(s). The substrate is one which brings about fluorescence emission or change in absorption as a result of the enzyme reaction.
• US4463090A
  申请人：——

  公开号：US4463090A

  公开（公告）日：1984-07-31

表征谱图