(R,S)-chondrocurine | 477-58-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R,S)-chondrocurine
• 英文别名: d-Chondrocurin；Chondocurine；Chondrocurine；tubocurine；6,6'-dimethoxy-2,2'-dimethyl-tubocurarane-7',12'-diol；6,6'-dimethoxy-2,2'-dimethyl-tubocuraran-7',12'-diol；Chondrocurin；(1S,16R)-10,25-dimethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.118,22.027,31.016,34]hexatriaconta-3(36),4,6(35),8(34),9,11,18(33),19,21,24,26,31-dodecaene-9,21-diol
• CAS: 477-58-7
• 化学式: C₃₆H₃₈N₂O₆
• 分子量: 594.708
• InChiKey: NGZXDRGWBULKFA-WUFINQPMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  44
• 可旋转键数：
  2
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  83.9
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  (R,S)-chondrocurine 在 甲醇 、 sodium acetate 、 乙酸酐 、 溶剂黄146 作用下， 生成 7',12'-diacetoxy-6,6'-dimethoxy-2,2,2',2'-tetramethyl-tubocurarandiium; diiodide
  参考文献：
  名称：

  Curare Alkaloids. II. The Purification of d-Tubocurarine Chloride and the Isolation of d-Chondocurarine¹

  摘要：

  DOI：

  10.1021/ja01129a021

文献信息

• PHARMACEUTICAL COMPOSITIONS CONTAINING TETRAHYDROISOQUINOLINE COMPOUNDS
  申请人：Korea Institute of Science and Technology

  公开号：EP1124554A1

  公开（公告）日：2001-08-22
• US6562837B1
  申请人：——

  公开号：US6562837B1

  公开（公告）日：2003-05-13
• [EN] PHARMACEUTICAL COMPOSITIONS CONTAINING TETRAHYDROISOQUINOLINE COMPOUNDS<br/>[FR] COMPOSITIONS PHARMACEUTIQUES RENFERMANT DES COMPOSES DE TETRAHYDROISOQUINOLEINE
  申请人：KOREA INST SCI & TECH

  公开号：WO2000023078A1

  公开（公告）日：2000-04-27

  Disclosed are pharmaceutical compositions for the treatment and prophylaxis of heart failure, thrombosis, iNOS-induced tissue injury, septicemia, and disseminated intravascular coagulation. The compositions comprise, as a pharmacologically active ingredient, the compounds represented by chemical formulas (1) and (2), each of them showing heart stimulating activity, hypotensive activity, inhibitory activity against platelet aggregation, and suppressive activity against iNOS expression in combination and at once.
• Hultin,E., Acta Chemica Scandinavica (1947-1973), 1961, vol. 15, p. 1130 - 1140
  作者：Hultin,E.

  DOI：——

  日期：——
• Curare Alkaloids. II. The Purification of d-Tubocurarine Chloride and the Isolation of d-Chondocurarine¹
  作者：James D. Dutcher

  DOI：10.1021/ja01129a021

  日期：1952.5