(4R,5R)-3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2-methoxy-[1,2]oxaphospholane 2-oxide | 544429-07-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4R,5R)-3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2-methoxy-[1,2]oxaphospholane 2-oxide
• CAS: 544429-07-4
• 化学式: C₂₃H₅₃O₆PSi₃
• 分子量: 540.9
• InChiKey: NBIYAEYOKIZGMT-YSZZDBGVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.98
• 重原子数：
  33.0
• 可旋转键数：
  8.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  63.22
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  草酰氯 、 (4R,5R)-3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2-methoxy-[1,2]oxaphospholane 2-oxide 反应 12.0h， 生成 (4R,5R)-3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2-chloro-[1,2]oxaphospholane 2-oxide
  参考文献：
  名称：

  Cyclic phosphonomethylphosphinates: a new type of phosphorus-containing sugars

  摘要：

  The first synthesis of arabino-configured cyclic phosphonomethylphosphinates is described. The key step is the condensation of the triethylester of H-phosphinylphosphonate 10 on an hydroxyaldehyde 11 derived from a D-arabinal derivative followed by a cyclization induced under acetylation conditions. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)00241-7
• 作为产物：
  描述：

  Formic acid (1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-oxo-propyl ester 在 sodium methylate 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 51.0h， 生成 (4R,5R)-3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2-methoxy-[1,2]oxaphospholane 2-oxide
  参考文献：
  名称：

  Cyclic phosphonomethylphosphinates: a new type of phosphorus-containing sugars

  摘要：

  The first synthesis of arabino-configured cyclic phosphonomethylphosphinates is described. The key step is the condensation of the triethylester of H-phosphinylphosphonate 10 on an hydroxyaldehyde 11 derived from a D-arabinal derivative followed by a cyclization induced under acetylation conditions. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)00241-7