(E)-6-methyl-1,8-diphenyloct-7-en-1-one | 1353557-75-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (E)-6-methyl-1,8-diphenyloct-7-en-1-one
• CAS: 1353557-75-1
• 化学式: C₂₁H₂₄O
• 分子量: 292.421
• InChiKey: IXVPAWJXSPISCP-WUKNDPDISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  6-bromo-1-phenylheptan-1-one 、 反式-2-苯乙烯硼酸频哪酸酯 在 叔丁基锂 、 十一烷 、 FeCl2(TMS-SciOPP) 、 magnesium bromide 作用下， 以 四氢呋喃 、 正戊烷 为溶剂， 反应 25.0h， 以83%的产率得到(E)-6-methyl-1,8-diphenyloct-7-en-1-one
  参考文献：
  名称：

  Stereospecific Cross-Coupling between Alkenylboronates and Alkyl Halides Catalyzed by Iron–Bisphosphine Complexes

  摘要：

  A stereospecific and high-yielding cross-coupling reaction between alkenylboron reagents and alkyl halides is described. The reaction has been achieved by using well-defined iron bisphosphine complexes such as 1b FeCl2(3,5-t-Bu-2-SciOPP), which was recently developed by the authors' group. Various nonactivated alkyl bromides and chlorides possessing a base/nucleophile-sensitive functional group can participate in the cross-coupling, demonstrating its utility for stereoselective synthesis of functional molecules bearing a carbon carbon double bond.

  DOI：

  10.1021/jo202151f

文献信息

• Stereospecific Cross-Coupling between Alkenylboronates and Alkyl Halides Catalyzed by Iron–Bisphosphine Complexes
  作者：Toru Hashimoto、Takuji Hatakeyama、Masaharu Nakamura

  DOI：10.1021/jo202151f

  日期：2012.1.20

  A stereospecific and high-yielding cross-coupling reaction between alkenylboron reagents and alkyl halides is described. The reaction has been achieved by using well-defined iron bisphosphine complexes such as 1b FeCl2(3,5-t-Bu-2-SciOPP), which was recently developed by the authors' group. Various nonactivated alkyl bromides and chlorides possessing a base/nucleophile-sensitive functional group can participate in the cross-coupling, demonstrating its utility for stereoselective synthesis of functional molecules bearing a carbon carbon double bond.