(4S,5S)-4-methyl-5-phenyl-3-[(2-methoxyphenyl)-acetyl]-oxazolidin-2-one | 146402-89-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4S,5S)-4-methyl-5-phenyl-3-[(2-methoxyphenyl)-acetyl]-oxazolidin-2-one
• 英文别名: (4S,5S)-4-methyl-5-phenyl-3-[(2-methoxyphenyl)acetyl]-2-oxazolidinone；(4S,5S)-4-methyl5-Phenyl-3-(2-methoxyphenylacetyl)-2-oxazolidinone；(4S,5S)-3-[2-(2-methoxyphenyl)acetyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one
• CAS: 146402-89-3
• 化学式: C₁₉H₁₉NO₄
• 分子量: 325.364
• InChiKey: AWWGCTHFNOCGCA-SCLBCKFNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (4S,5S)-4-methyl-5-phenyl-3-[(2-methoxyphenyl)-acetyl]-oxazolidin-2-one 、 、 碘甲烷 在 水 、 magnesium sulfate 、 异丙醚 作用下， 以 四氢呋喃 、 乙酸乙酯 为溶剂， -50.0~25.0 ℃ 、359.97 kPa 条件下， 反应 15.75h， 以4.2 g of (4S,5S)-4-methyl-5-phenyl-3-[(S)-2-(2-methoxyphenyl)propionyl]-2-oxazolidinone are obtained, in the form of a white solid的产率得到(4S,5S)-4-methyl-5-phenyl-3-[2-(2-methoxyphenyl)-(S)-propionyl]-oxazolidin-2-one
  参考文献：
  名称：

  Perhydroisoindole derivatives, preparation thereof and pharmaceutical

  摘要：

  本发明涉及08/448,402公式(I)的过氢化异吲哚衍生物，其中基团R是苯基团，可选地被卤原子或甲基基团取代的2-或3-取代基；R.sub.1是可选取代的苯基、环己二烯基、萘基、茚基或可选取代的杂环基；R.sub.2是H、卤素、OH、烷基、氨基烷基、烷基氨基烷基、二烷基氨基烷基、烷氧基、烷硫基、酰氧基、酰氨基、可选取代的烷氧羰基、苄氧羰基、氨基或酰胺基；R.sub.3是可选地2-取代的苯基；在适用的情况下，可选地为其盐；以及其制备方法。所述衍生物特别适用于神经激肽A拮抗剂。##STR1##

  公开号：

  US05631279A1
• 作为产物：
  描述：

  2-甲氧基苯乙酸 、 三甲基乙酰氯 、 ((4S,5S)-4-甲基-5-苯基-2-恶唑烷酮 在 正丁基锂 、 sodium chloride 、 氮气 、 ammonium chloride 作用下， 以 四氢呋喃 、 vaseline 、 正己烷 、 环己烷 、 乙酸乙酯 为溶剂， 生成 (4S,5S)-4-methyl-5-phenyl-3-[(2-methoxyphenyl)-acetyl]-oxazolidin-2-one
  参考文献：
  名称：

  Perhydroisoindole derivatives and preparation

  摘要：

  本发明涉及具有式(I)的新颖全氢异吲哚衍生物，##STR1## 其中符号R，相同或不同，为任选2位或3位被卤素原子或甲基取代的苯基，R'为任选2位被C1-2烷基或烷氧基取代的苯基，R"为氟原子或羟基，R'"为氢原子，或者R'和R'"均为羟基，或者R"和R'"一起形成一个键，R°为氢原子或保护基；以及适当时它们的盐；及其制备方法。这些产品是制备具有P物质拮抗活性的衍生物的合成中间体。

  公开号：

  US05463077A1

文献信息

• Perhydroisoindole derivatives and preparation
  申请人：Rhone-Poulenc Rorer S.A.

  公开号：US05463077A1

  公开（公告）日：1995-10-31

  This ivention relates to novel perhydroisoindole derivatives having formula (I), ##STR1## wherein the symbols R, which are the same or different, are phenyl radicals optionally 2- or 3-substituted by a halogen atom or a methyl radical, R' is a phenyl radical optionally 2-substituted by a C.sub.1-2 alkylk or alkyloxy radical, R" is a fluorine atom or a hydroxy radical, and R'" is a hydrogen atom, or else R' and R'" are hydroxy radicals, or R" and R'" together form a bond, and R.sup.o is a hydrogen atom or a protective radical; salts thereof whereever applicable; and preparation thereof. These products are synthetic intermediates for the preparation of derivatives having P substance antagonist activity.

  本发明涉及具有式(I)的新颖全氢异吲哚衍生物，##STR1## 其中符号R，相同或不同，为任选2位或3位被卤素原子或甲基取代的苯基，R'为任选2位被C1-2烷基或烷氧基取代的苯基，R"为氟原子或羟基，R'"为氢原子，或者R'和R'"均为羟基，或者R"和R'"一起形成一个键，R°为氢原子或保护基；以及适当时它们的盐；及其制备方法。这些产品是制备具有P物质拮抗活性的衍生物的合成中间体。
• Perhydroisoindole derivatives as antagonists of substance P
  申请人：Rhone-Poulenc Rorer S.A.

  公开号：US05484804A1

  公开（公告）日：1996-01-16

  This invention relates to novel perhydroisoindole derivatives of general formula (I), ##STR1## wherein radicals R are phenyl radicals optionally 2- or 3-substituted by a halogen atom or a methyl radical; R.sub.1 is optionally substituted phenyl, cyclohexadienyl, naphthyl, indenyl or optionally substituted heterocyclyl; R.sub.2 is H, halogen, OH, alkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkyloxy, alkylthio, acyloxy, carboxy, optionally substituted alkyloxycarbonyl, benzyloxycarbonyl, amino or acylamino; R.sub.3 is optionally 2-substituted phenyl; R.sub.4 is OH or fluorine when R.sub.5 is H, or R.sub.4 and R.sub.5 are OH or R.sub.4 and R.sub.5 together form a bond; isomeric forms and mixtures thereof; optionally salts thereof where applicable; and preparation thereof. The novel derivatives are particularly useful as P substance antagonists.

  本发明涉及通式(I)的新型全氢异吲哚衍生物，##STR1##其中基团R是可选择地2位或3位被卤素原子或甲基取代的苯基；R1是可选择地被取代的苯基、环己二烯基、萘基、茚基或可选择地被取代的杂环基；R2是氢、卤素、羟基、烷基、氨基烷基、烷基氨基烷基、二烷基氨基烷基、烷氧基、烷硫基、酰氧基、羧基、可选择地被取代的烷氧羰基、苄氧羰基、氨基或酰氨基；R3是可选择地2位被取代的苯基；当R5是氢时，R4是羟基或氟，或者R4和R5是羟基，或者R4和R5一起形成一个键；异构体形式及其混合物；在适用的情况下可选择地形成盐；以及它们的制备方法。这些新型衍生物特别有用作P物质拮抗剂。
• Perhydroisoindole derivatives and pharmaceutical compositions containing
  申请人：Rhone-Poulenc Rorer S.A.

  公开号：US05451601A1

  公开（公告）日：1995-09-19

  This invention relates to derivatives of perhydroisoindol of formula: ##STR1## in which the radicals R are hydrogen atoms or together form a bond, the symbols R' are phenyl radicals which can be substituted by a halogen atom or a methyl radical in position 2 or 3, X is an oxygen atom or an NH radical, R.sub.1 is optionally substituted phenyl, or cyclohexadienyl, naphthyl, or heterocyclyl, R.sub.2 is H, halogen, OH, alkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkyloxy, alkylthio, acyloxy, carboxy, optionally substituted alkyloxycarbonyl, benzyloxycarbonyl, amino or acylamino, R.sub.3 is halogen or OH and R.sub.4 is H or halogen if R.sub.3 is halogen, in their isomer forms, or mixture thereof, and possibly also their salts when they exist, and preparation thereof. The derivatives of the invention are particularly interesting as P substance antagonist.

  本发明涉及通式为：##STR1##的环己二烯并异吲哚衍生物，其中基团R为氢原子或共同形成一个键，符号R'为可被2位或3位上的卤素原子或甲基取代的苯基，X为氧原子或NH基团，R1为可选择性取代的苯基、环己二烯基、萘基或杂环基，R2为H、卤素、OH、烷基、氨基烷基、烷基氨基烷基、二烷基氨基烷基、烷氧基、烷硫基、酰氧基、羧基、可选择性取代的烷氧羰基、苄氧羰基、氨基或酰胺基，R3为卤素或OH，R4为H或卤素（如果R3为卤素），包括其异构体形式或混合物，以及可能存在的盐及其制备方法。本发明的衍生物特别有趣的是作为P物质拮抗剂。
• Perhydroisoindole derivatives as substance P antagonists
  申请人：Rhone-Poulenc Rorer S.A.

  公开号：US05739351A1

  公开（公告）日：1998-04-14

  New perhydroinsoindole having the general formula (I) wherein R.sub.1 is optionally substituted phenyl or is cyclohexadienyl, naphtyl, indenyl or mono or polycyclic heterocyclyl, saturated or unsaturated 5 to 9C and optionally substituted, R.sub.2 is H or halogen, OH, alkyl, amino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkyloxy, alkylthio, acyloxy, carboxy, alkyloxycarbonyl, dialkylaminoalcyloxycarbonyl, benzyloxycarbonyl, amino or acylamino, R.sub.3 is phenyl optionally substituted in position -2 by a radical alkyl or alkyloxy 1 or 2C or by OH or F, or disubstituted by CF.sub.3, and R.sub.4 is an alkyl radical containing 1 or 2C substituted by halogen or CN, N.sub.3 or --NHCN, and the radicals R which are similar or different represent H, alkyl or phenyl, in their isomer forms having the structure (Ia) or mixtures thereof, optionally their salts when they exist and preparation thereof. The new derivatives of the invention are particularly useful as antagonists of substance P.

  新的过氢化异吲哚具有通式（I），其中R.sub.1是可选取代苯基或环己二烯基、萘基、茚基或单环或多环杂环基，饱和或不饱和5到9C并可选取代，R.sub.2是H或卤素、OH、烷基、氨基、氨基烷基、烷基氨基烷基、二烷基氨基烷基、烷氧基、烷硫基、酰氧基、羧基、烷氧羰基、二烷基氨基羰氧基、苄氧羰基、氨基或酰胺基，R.sub.3是苯基，可选取代于位置-2上的基团烷基或烷氧基1或2C或OH或F，或被CF.sub.3二取代，R.sub.4是含有1或2C的烷基，被卤素或CN、N.sub.3或--NHCN取代，以及相似或不同的基团R，代表H、烷基或苯基，在它们的异构体形式中具有结构（Ia）或其混合物，选用它们的盐（如果存在）及其制备方法。本发明的新衍生物特别适用于作为物质P的拮抗剂。
• Thiopyranopyrrole derivatives
  申请人：Rhone-Poulenc Rorer S.A.

  公开号：US05484942A1

  公开（公告）日：1996-01-16

  This invention relates to novel derivatives of thiopyranopyrrole of general formula (I): ##STR1## in which R is hydrogen, allyl, or a radical having the structure: --CR.sub.a R.sub.b R.sub.c where R.sub.a and R.sub.b are hydrogen atoms or phenyl radicals optionally substituted (by halogen, alkyl, alkyloxy or nitro), and R.sub.c is defined as R.sub.a and R.sub.b or stands for an alkyl or alkyloxyalkyl radical, at least one of R.sub.a, R.sub.b and R.sub.c being a substituted or unsubstituted phenyl radical, and n is 0 to 2, in their stereoisomer forms, and mixtures thereof, and possibly the salts if they exist, and preparation thereof. The novel derivatives of the invention are particularly interesting as synthesis intermediates.

  本发明涉及一种新型的噻吩并吡咯衍生物，其一般式为(I)：##STR1## 其中R为氢、丙烯基或具有以下结构的基团：--CR.sub.a R.sub.b R.sub.c，其中R.sub.a和R.sub.b为氢原子或苯基，可选择地被卤素、烷基、烷氧基或硝基取代，而R.sub.c被定义为R.sub.a和R.sub.b或代表一种烷基或烷氧基烷基基团，其中至少有一个R.sub.a、R.sub.b和R.sub.c是取代或未取代的苯基，n为0至2，在它们的立体异构体形式和混合物中，以及可能的盐（如果存在）和制备方法。本发明的新型衍生物特别适用于合成中间体。