9-Chloro-5,6,7,8-tetrahydro-acridine-3-carboxylic acid [1-(3-methyl-benzyl)-piperidin-4-ylmethyl]-amide | 902438-68-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-Chloro-5,6,7,8-tetrahydro-acridine-3-carboxylic acid [1-(3-methyl-benzyl)-piperidin-4-ylmethyl]-amide
• 英文别名: 9-chloro-N-[[1-[(3-methylphenyl)methyl]piperidin-4-yl]methyl]-5,6,7,8-tetrahydroacridine-3-carboxamide
• CAS: 902438-68-0
• 化学式: C₂₈H₃₂ClN₃O
• 分子量: 462.035
• InChiKey: NYYLFPZMXQKHJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  45.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氨基对苯二甲酸 在 三乙胺 、 三氯氧磷 作用下， 以 二苯醚 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 9-Chloro-5,6,7,8-tetrahydro-acridine-3-carboxylic acid [1-(3-methyl-benzyl)-piperidin-4-ylmethyl]-amide
  参考文献：
  名称：

  Amidoacridine derivatives useful as selective inhibitors of ubiquitin specific protease 7

  摘要：

  本发明涉及发现新的选择性泛素特异性蛋白酶抑制剂、它们的制备过程及其治疗用途。

  公开号：

  EP2357176A1

文献信息

• Amidoacridine derivatives useful as selective inhibitors of ubiquitin specific protease 7
  申请人：Hybrigenics S.A.

  公开号：EP2357176A1

  公开（公告）日：2011-08-17

  The present invention concerns the discovery of new selective inhibitors of ubiquitin specific proteases, their process of preparation and their therapeutic use.

  本发明涉及发现新的选择性泛素特异性蛋白酶抑制剂、它们的制备过程及其治疗用途。
• COMPOUNDS FOR TREATMENT OF CANCER AND EPIGENETICS
  申请人：Agency For Science, Technology and Research

  公开号：US20190071416A1

  公开（公告）日：2019-03-07

  Compounds For Inhibition Of Cancer and Epigenesis. The present invention relates to quinolines and 5,6,7,8-tetrahydroacridines of the formula (I) wherein Z 1 , Z 2 , X, R 1 to R 8 and Y are defined as described in the specification, or a pharmaceutically acceptable form or prodrug thereof, that are inhibitors of methyl transferases such as protein lysine methyltransferases and more particularly SMYD3. The present invention also relates to the methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of disorders/conditions/diseases involving, relating to or associated with enzymes having methyl transferase activities/functions and/or via unspecified/multi-targeted mechanisms.
• [EN] AMIDOACRIDINE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7<br/>[FR] DÉRIVÉS D'AMIDOACRIDINE UTILES COMME INHIBITEURS SÉLECTIFS DE LA PROTÉASE SPÉCIFIQUE À L'UBIQUITINE 7
  申请人：HYBRIGENICS SA

  公开号：WO2011086178A1

  公开（公告）日：2011-07-21

  The present invention concerns the discovery of new selective inhibitors of ubiquitin specific proteases, their process of preparation and their therapeutic use.
• Novel Selective Inhibitors of Ubiquitin Specific Protease 7, the Pharmaceutical Compositions Thereof and Their Therapeutic Applications
  申请人：Lopez Roman

  公开号：US20110177105A1

  公开（公告）日：2011-07-21

  The present invention concerns the discovery of new selective inhibitors of ubiquitin specific proteases, their process of preparation and their therapeutic use.

  本发明涉及发现新的选择性抑制泛素特异性蛋白酶的化合物，以及它们的制备方法和治疗用途。