3-(chloromethyl)-4-methoxypyridine | 1196151-71-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(chloromethyl)-4-methoxypyridine
• CAS: 1196151-71-9
• 化学式: C₇H₈ClNO
• mdl: MFCD13189629
• 分子量: 157.6
• InChiKey: DVLWRRDACHRIHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(chloromethyl)-4-methoxypyridine 在 二异丁基氢化铝 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 7.5h， 生成 tert-butyl 6-formyl-6-[(4-methoxy-3-pyridyl)methyl]-2-azaspiro[3.3]heptane-2-carboxylate
  参考文献：
  名称：

  [EN] AZETIDINE AND SPIROAZETIDINE COMPOUNDS AND USES THEREOF
  [FR] COMPOSÉS D'AZÉTIDINE ET DE SPIROAZÉTIDINE ET LEURS UTILISATIONS

  摘要：

  The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

  公开号：

  WO2023107547A2
• 作为产物：
  描述：

  (4-甲氧基-3-吡啶基)甲醇 在 氯化亚砜 作用下， 以 氯仿 为溶剂， 以76 %的产率得到3-(chloromethyl)-4-methoxypyridine
  参考文献：
  名称：

  [EN] AZETIDINE AND SPIROAZETIDINE COMPOUNDS AND USES THEREOF
  [FR] COMPOSÉS D'AZÉTIDINE ET DE SPIROAZÉTIDINE ET LEURS UTILISATIONS

  摘要：

  The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

  公开号：

  WO2023107547A2

文献信息

• 2,4-DIAMINOPYRIMIDINE COMPOUND
  申请人：Tanaka Akira

  公开号：US20110159019A1

  公开（公告）日：2011-06-30

  Provided is a compound which is useful as an active ingredient for a pharmaceutical having a PKCθ inhibition activity, particularly a pharmaceutical composition for inhibiting acute rejection occurring in transplantation. The present inventors have conducted extensive studies on a compound having a PKCθ inhibition activity, and as a result, they have found that a compound having a structure such as aralkyl and the like on an amino group at the 2-position and also having a structure such as an adamantylalkyl group and the like on an amino group at the 4-position of 2,4-diaminopyrimidine, or a salt thereof has an excellent PKCθ inhibition activity, thereby completing the present invention. The 2,4-diaminopyrimidine compound of the present invention can be used as a PKCθ inhibitor or an inhibitor of acute rejection occurring in transplantation.

  提供了一种化合物，可用作具有PKCθ抑制活性的药物的活性成分，尤其是用于抑制移植中发生的急性排斥的药物组合物。本发明者对具有PKCθ抑制活性的化合物进行了广泛的研究，结果发现，在2-位氨基上具有类似芳基烷基等结构，在4-位氨基上具有类似于金刚烷基烷基等结构的2,4-二氨基嘧啶化合物，或其盐具有出色的PKCθ抑制活性，从而完成了本发明。本发明的2,4-二氨基嘧啶化合物可用作PKCθ抑制剂或用于抑制移植中发生的急性排斥的抑制剂。
• EP2325175
  申请人：——

  公开号：——

  公开（公告）日：——
• [EN] AZETIDINE AND SPIROAZETIDINE COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS D'AZÉTIDINE ET DE SPIROAZÉTIDINE ET LEURS UTILISATIONS
  申请人：[en]KINETA, INC.

  公开号：WO2023107547A2

  公开（公告）日：2023-06-15

  The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.