1,2,3,4,5,5,6,7,9,10,10-十一氯五环(5.3.0.0.0.0)癸烷 | 39801-14-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 1,2,3,4,5,5,6,7,9,10,10-十一氯五环(5.3.0.0.0.0)癸烷
• 英文名称: photomirex
• 英文别名: 1,2,3,4,5,5,6,7,9,10,10-undecachloropentacyclo[5.3.0.02,6.03,9.04,8]decane
• CAS: 39801-14-4
• 化学式: C₁₀HCl₁₁
• 分子量: 511.101
• InChiKey: KFDNXHKRTQRVGV-UHFFFAOYSA-N

物化性质

• 沸点：
  575.76°C (rough estimate)
• 密度：
  1.8747 (rough estimate)
• 溶解度：
  可溶于氯仿（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 危险等级：
  6.1(b)
• 包装等级：
  III
• 危险类别：
  6.1(b)
• 危险品运输编号：
  UN 2761

反应信息

• 作为产物：
  描述：

  灭蚁灵 在 humic acid 、 2-氯乙醇 作用下， 以 甲醇 、 水 为溶剂， 生成 1,2,3,4,5,5,6,7,9,10,10-十一氯五环(5.3.0.0.0.0)癸烷
  参考文献：
  名称：

  Mechanistic Implications of the Intrahumic Dechlorination of Mirex

  摘要：

  The hydrophobic chlorocarbon mirex readily binds to aqueous humic acids (HAs). In HA solutions irradiated at sunlight wavelengths (lambda greater than or equal to 290 nm), mirex molecules bound to HAs are transformed to photomirex by dechlorination. The mechanism of this intrahumic dechlorination was investigated both in HA solutions and in model systems simulating select photochemical capabilities of HAs. In HA solution, the reaction was unaffected by methanol and pentanol; was accelerated by hydroxide; and was inhibited by oxygen, 2-chloroethanol, nitrate, and hydrogen ion, all four of which can scavenge hydrated electron. Additional experiments probing for involvement of hydrated electron were consistent with it as the reactant. In irradiated N,N-dimethylaniline solution, a model system for generating hydrated electron, mirex was dechlorinated to form photomirex, the same product that is found in HA solution. Relative rate experiments in HA solution, while inconsistent with the reaction with hydrated electron in homogeneous solution, were consistent with reaction with a purely intrahumic hydrated electron. However, other humic-generated reductants cannot be eliminated as possible reactants. The potential confounding influence of hydrophobic partitioning to HAs on investigations using molecular probes is evaluated in terms of current data and previous reports.

  DOI：

  10.1021/es960581l

文献信息

• Binding Effects on Humic-Mediated Photoreaction:  Intrahumic Dechlorination of Mirex in Water
  作者：Susan E. Burns、John P. Hassett、Maura V. Rossi

  DOI：10.1021/es950906i

  日期：1996.9.1

  A kinetic model was developed describing the effects of hydrophobic partitioning to humics on second-order humic-mediated photoreactions in aqueous solution. Model development and evaluation were in terms of the humic-mediated dechlorination of the hydrophobic chlorocarbon, mirex. Mirex dechlorination in irradiated (lambda greater than or equal to 290 nm) Aldrich humic acid (HA) solution was examined as a function of humic acid and scavenger concentration. Kinetic models in which HA solution is described as a homogeneous or single-phase solution were not able to describe the effects of HA and scavenger concentrations on mirex dechlorination rates. However, these effects were successfully described by including partitioning in the models to characterize the bound phase and dissolved phase mirex reactions separately. The resulting model uses homogeneous phase kinetics to describe reaction in the dissolved phase. Bound phase reaction is described as occurring within individual HA molecules with the distribution of scavengers within HA molecules following a Poisson distribution. Used to assess the relative reactivities of the bound and dissolved phases, the model indicated that the reaction of mirex in HA solution is confined to the humic phase. The general predictions and utility of the model are evaluated both in terms of experimental data and pollutant photodegradation.
• HERPES VIRUS-BASED COMPOSITIONS AND METHODS OF USE IN THE PRENATAL AND PERINATAL PERIODS
  申请人：THE UNIVERSITY OF ROCHESTER

  公开号：EP1903873A2

  公开（公告）日：2008-04-02
• Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby
  申请人：West D. Michael

  公开号：US20080070303A1

  公开（公告）日：2008-03-20

  This invention generally relates to methods to differentiate pluripotent stem cells, such as embryonic stem, embryonic germ, or embryo-derived cells, to obtain subpopulations of cells from heterogeneous mixtures of cells wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated.
• Herpes Virus-Based Compositions and Methods of Use in the Prenatal and Perinatal Periods
  申请人：Federoff Howard J.

  公开号：US20080226601A1

  公开（公告）日：2008-09-18

  Disclosed are compositions and methods for reducing the severity of a birth defect in a mammal by exposing the mammal (e.g., in utero) to a herpes virus amplicon particle comprising a cis element-flanked transgene and a sequence encoding a transposase. Upon expression, the transposase inserts the transgene into the genome of a cell (e.g., a neuron) within the mammal and the transgene expresses a polypeptide or RNA that compensates for a protein or gene defect that is causally associated with the birth defect.
• METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY
  申请人：West Michael D.

  公开号：US20100184033A1

  公开（公告）日：2010-07-22

  Aspects of the present invention relate to methods to differentiate pluripotent primordial stem cells, such as human embryonic stem (“hES”) cells, human embryonic germ (“hEG”) cells, human embryo-derived (“hED”) cells and human embryonal carcinoma (“hEC”) cells, to obtain subpopulations of cells from heterogeneous mixtures of cells, wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated 20 or more population doublings. This invention also provides novel compositions of such subpopulations of cells and methods to propagate and differentiate said cells.