4-甲基伞形酮-a-L-呋喃阿拉伯糖苷 | 77471-44-4

• 物质功能分类: 生物化工 - 糖类化合物 - 单糖
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 中文名称: 4-甲基伞形酮-a-L-呋喃阿拉伯糖苷
• 中文别名: 4-甲基香豆素基-Α-L-呋喃阿拉伯糖苷
• 英文名称: 7-hydroxy-4-methylcoumarin-7-yl α-L-arabinofuranoside
• 英文别名: 4-methylumbelliferyl α-L-arabinofuranoside；4-Methylumbelliferyl alpha-L-arabinofuranoside；7-[(2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4-methylchromen-2-one
• CAS: 77471-44-4
• 化学式: C₁₅H₁₆O₇
• mdl: MFCD00057308
• 分子量: 308.288
• InChiKey: FAGLTVBWEMHJRP-SPWCGHHHSA-N

物化性质

• 沸点：
  599.4±50.0 °C(Predicted)
• 密度：
  1.486±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  7

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S24,S45,S7
• 危险类别码：
  R20/22
• WGK Germany：
  1
• 海关编码：
  29400090
• 危险标志：
  GHS07,GHS08
• 危险性描述：
  H302,H370
• 危险性防范说明：
  P301 + P312 + P330,P308 + P311

反应信息

• 作为产物：
  描述：

  2,3,5-tri-O-benzoyl-α-L-arabinofuranosyl bromide 在 氨 、 potassium carbonate 作用下， 以 甲醇 、 丙酮 为溶剂， 反应 88.0h， 生成 4-甲基伞形酮-a-L-呋喃阿拉伯糖苷
  参考文献：
  名称：

  Preparation of some aryl α-l-arabinofuranosides as substrates for arabino-furanosidase

  摘要：

  DOI：

  10.1016/0008-6215(88)84045-x

文献信息

• Alpha-L-arabinofuranosidase histochemical reporter gene assay
  申请人：Sauer L. Brian

  公开号：US20060094031A1

  公开（公告）日：2006-05-04

  The present invention provides a novel reporter gene assay. In particular, the present invention provides a histochemical reporter gene assay employing α- L -arabinofuranosidase in combination with a chromogenic α- L -arabinofuranosidase substrate. The α- L -arabinofuranosidase histochemical reporter assay may be utilized to characterize gene regulatory regions of interest either alone or in combination with other assays.

  本发明提供了一种新型的报告基因测定法。特别地，本发明提供了一种利用α-L-阿拉比诺糖苷酶与色原性α-L-阿拉比诺糖苷酶底物结合的组织化学报告基因测定法。α-L-阿拉比诺糖苷酶组织化学报告测定法可用于单独或与其他测定法结合使用，以表征感兴趣的基因调控区域。
• Cellulose degrading enzymes of aspergillus
  申请人：——

  公开号：US20040001904A1

  公开（公告）日：2004-01-01

  Two cellobiohydrolase polypeptides (CBHA and CBHB) derived from Aspergillus are described and can be used to degrade cellulose. Variants of these peptides are described as well as DNA encoding the peptides, vectors and host cells. The peptides can be used to produce or process food, animal feed, wood pulp, paper and textiles.

  本文描述了两种源自曲霉菌的纤维素酶聚肽（CBHA和CBHB），可用于降解纤维素。还描述了这些肽的变异体以及编码这些肽的DNA、载体和宿主细胞。这些肽可以用于生产或加工食品、动物饲料、木浆、纸张和纺织品。
• Bread improving composition
  申请人：GIST-BROCADES B.V.

  公开号：EP0897667A2

  公开（公告）日：1999-02-24

  The present invention discloses a bread improving composition containing cellobiohydrolase and its use in bread making.

  本发明公开了一种含有纤维生物水解酶的面包改良组合物及其在面包制作中的应用。
• A novel method to isolate mutants and to clone the complementing gene
  申请人：DANISCO A/S

  公开号：EP1514936A2

  公开（公告）日：2005-03-16

  The subject invention lies in the field of microorganism mutation and selection of the mutants. In particular, the invention is directed at obtaining metabolic mutants in a simple, direct and specific manner. In a preferred embodiment it is also possible to obtain desired mutants not comprising recombinant DNA, thereby facilitating incorporation thereof in products for human consumption or application, due to shorter legislative procedures. The method according to the invention involves random mutation and specific selection of the desired metabolic mutant. A nucleic acid cassette comprising a nucleic acid sequence encoding a bidirectional marker, said nucleic acid cassette further comprising a basic transcriptional unit operatively linked to the nucleic acid sequence encoding the bidirectional marker and said nucleic acid cassette further comprising an inducible enhancer or activator sequence linked to the basic transcription unit in such a manner that upon induction of the enhancer or activator sequence the bidirectional marker encoding nucleic acid sequence is expressed, said inducible enhancer or activator sequence being derived from a gene associated with activity of part of metabolism, said inducible enhancer.or activator sequence being derived from a gene associated with metabolism is claimed as is application thereof in a selection method for mutants. In addition a regulator gene xlnR encoding an activating regulator of an inducible enhancer or activator sequence and application of said gene and/or its expression product in overexpression of homologous or heterologous protein or peptide is described. Knockout mutants wherein said gene is absent or inactivated and mutants with increased or decreased DNA binding capacity are also claimed.

  本发明涉及微生物突变和突变体选择领域。特别是，本发明旨在以简单、直接和特异的方式获得代谢突变体。在一个优选的实施方案中，还可以获得不包含重组 DNA 的所需突变体，从而由于缩短了立法程序，便于将其加入供人类消费或应用的产品中。本发明的方法包括随机突变和特异性选择所需的代谢突变体。一种核酸盒，包括编码双向标记的核酸序列，所述核酸盒进一步包括与编码双向标记的核酸序列可操作地连接的基本转录单元，所述核酸盒进一步包括与基本转录单元连接的可诱导的增强子或激活子序列，其连接方式为当增强子或激活子序列被诱导时，编码双向标记的核酸序列被表达、所述可诱导的增强子或激活子序列来自与部分代谢活动有关的基因，所述可诱导的增强子。或激活剂序列来源于与新陈代谢有关的基因，要求将其应用于突变体的选择方法中。此外，还描述了一种编码可诱导增强子或激活子序列的激活调节因子的调节基因 xlnR，以及所述基因和/或其表达产物在过表达同源或异源蛋白质或肽中的应用。此外，还提出了上述基因缺失或失活的基因敲除突变体，以及 DNA 结合能力增强或减弱的突变体。
• METHOD TO READ BIOLOGICAL INDICATOR
  申请人：Ethicon, Inc.

  公开号：EP3366315A1

  公开（公告）日：2018-08-29

  A method for detecting biological activity in a biological indicator comprises the steps of providing a known quantity of spores containing a fixed number of copies of an enzyme and a liquid growth medium comprising substrates of the enzyme. The enzyme substrates have a first emission spectrum, and are configured to be converted by the enzyme to substrate derivatives having a second emission spectrum. The spores are exposed to the liquid growth medium, and the liquid growth medium is measured for the second emission spectrum, and either no change in the second emission spectrum or a linear increase in the second emission spectrum, is detected as a function of time.

  一种检测生物指示剂中生物活性的方法包括以下步骤：提供已知数量的孢子，其中含有固定拷贝数的酶和含有酶底物的液体生长培养基。酶底物具有第一发射光谱，并可被酶转化为具有第二发射光谱的底物衍生物。孢子暴露在液体生长介质中，测量液体生长介质的第二发射光谱，检测第二发射光谱随时间的变化是无变化还是线性增加。