8-SH-3-CONHBn-quinoline | 1414879-48-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-SH-3-CONHBn-quinoline
• 英文别名: N-benzyl-8-sulfanylquinoline-3-carboxamide
• CAS: 1414879-48-3
• 化学式: C₁₇H₁₄N₂OS
• 分子量: 294.377
• InChiKey: ZMAZKEPGGBKVCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  43
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  diethyl [(2-fluoroanilino)methylidene]malonate 在 盐酸 、 palladium 10% on activated carbon 、 氢气 、 sodium hydride 、 1-羟基苯并三唑 、 三乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 、 三氯氧磷 作用下， 以 甲醇 、 二苯醚 、 水 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 20.0~250.0 ℃ 、344.75 kPa 条件下， 反应 23.0h， 生成 8-SH-3-CONHBn-quinoline
  参考文献：
  名称：

  [EN] 8-THIO QUINAZOLINE DERIVATIVES AND 8-THIO QUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHODS FOR JAMM PROTEIN INHIBITION
  [FR] COMPOSITIONS ET MÉTHODES D'INHIBITION DES PROTÉINES JAMM

  摘要：

  公开号：

  WO2014066506A3

文献信息

• [EN] INHIBITORS OF RPN11<br/>[FR] INHIBITEURS DE RPN11
  申请人：CALIFORNIA INST OF TECHN

  公开号：WO2017031255A1

  公开（公告）日：2017-02-23

  Candidate compounds for specific inhibition of Rpn11 are represented by Formula 1a where each of R2, R3, R4, R5, R6, and R7 is independently selected from hydrogen (H), substituted and unsubstituted alkyl groups, carboxyl groups, or substituted and unsubstituted carboxyamides.

  候选用于特定抑制Rpn11的化合物由Formula 1a代表，其中R2、R3、R4、R5、R6和R7中的每一个独立选择自氢（H）、取代和未取代的烷基基团、羧基团或取代和未取代的羧酰胺。
• COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION
  申请人：Cleave Biosciences, Inc.

  公开号：US20140235548A1

  公开（公告）日：2014-08-21

  Compounds, pharmaceutical compositions, and methods of using such compounds to treat or prevent diseases or disorders associated with or mediated by JAMM proteins are disclosed. The compounds and compositions inhibit the enzymatic activity of a JAMM domain, including the JAMM domain of the CSN5 subunit of the COP9-signalsome (CSN), the JAMM domain of the Rpn11/Poh1/Psmd14 subunit of the 26S proteasome, the JAMM domain of AMSH, the JAMM domain of AMSH-LP, the JAMM domain of BRCC36, among other JAMM domains.

  本文介绍了化合物、药物组合物以及使用这些化合物治疗或预防与JAMM蛋白相关或介导的疾病或障碍的方法。这些化合物和组合物抑制JAMM域的酶活性，包括COP9信号体（CSN）的CSN5亚基的JAMM域、26S蛋白酶的Rpn11/Poh1/Psmd14亚基的JAMM域、AMSH的JAMM域、AMSH-LP的JAMM域、BRCC36的JAMM域等其他JAMM域。
• Inhibitors of RPN11
  申请人：California Institute of Technology

  公开号：US10005735B2

  公开（公告）日：2018-06-26

  Candidate compounds for specific inhibition of Rpn11 are represented by Formula 1a where each of R2, R3, R4, R5, R6, and R7 is independently selected from hydrogen (H), substituted and unsubstituted alkyl groups, carboxyl groups, or substituted and unsubstituted carboxyamides.

  特异性抑制 Rpn11 的候选化合物由式 1a 表示 其中 R2、R3、R4、R5、R6 和 R7 各自独立地选自氢（H）、取代和未取代的烷基、羧基或取代和未取代的羧酰胺。
• INHIBITORS OF RPN11
  申请人：California Institute of Technology

  公开号：US20170050931A1

  公开（公告）日：2017-02-23

  Candidate compounds for specific inhibition of Rpn11 are represented by Formula 1a where each of R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 is independently selected from hydrogen (H), substituted and unsubstituted alkyl groups, carboxyl groups, or substituted and unsubstituted carboxyamides.
• [EN] COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION<br/>[FR] COMPOSITION ET PROCÉDÉS POUR L'INHIBITION DES PROTÉINES JAMM
  申请人：ZHOU HAN-JIE

  公开号：WO2012158435A1

  公开（公告）日：2012-11-22

  Compounds, pharmaceutical compositions, and methods of using such compounds to treat or prevent diseases or disorders associated with or mediated by JAMM proteins are disclosed. The compounds and compositions inhibit the enzymatic activity of a JAMM domain, including the JAMM domain of the CSN5 subunit of the COP9-signalsome (CSN), the JAMM domain of the Rpn11/Poh1/Psmd14 subunit of the 26S proteasome, the JAMM domain of AMSH, the JAMM domain of AMSH-LP, the JAMM domain of BRCC36, among other JAMM domains.