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O-烯丙基羟胺 盐酸盐 水合物 | 6542-54-7

中文名称
O-烯丙基羟胺 盐酸盐 水合物
中文别名
邻烯丙基羟胺盐酸盐水合物;O-烯丙基羟胺盐酸盐水合物
英文名称
O-allyl-hydroxylamine hydrochloride monohydrate
英文别名
O-allylhydroxylamine hydrochloride hydrate;O-prop-2-enylhydroxylamine;hydrate;hydrochloride
O-烯丙基羟胺 盐酸盐 水合物化学式
CAS
6542-54-7;206557-03-1
化学式
C3H7NO*ClH*H2O
mdl
——
分子量
127.571
InChiKey
VYCHJEXJHFTAQI-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 熔点:
    175 °C (dec.) (lit.)
  • 溶解度:
    溶于甲醇,溶解度25mg/mL,透明,无色

计算性质

  • 辛醇/水分配系数(LogP):
    -0.34
  • 重原子数:
    7
  • 可旋转键数:
    2
  • 环数:
    0.0
  • sp3杂化的碳原子比例:
    0.33
  • 拓扑面积:
    36.2
  • 氢给体数:
    3
  • 氢受体数:
    3

安全信息

  • 海关编码:
    2922199090

SDS

SDS:f1468da09f1bc7de1dac70dd4c573997
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反应信息

  • 作为反应物:
    描述:
    O-烯丙基羟胺 盐酸盐 水合物N-Boc-4-氧代-脯氨酸吡啶盐酸 作用下, 以 乙醇乙酸乙酯 为溶剂, 以94%的产率得到(2S,4EZ)-4-[(allyl-oxy)imino]-1-(tert-butoxycarbonyl)-2-pyrrolidinecarboxylic acid
    参考文献:
    名称:
    Pharmaceutically active pyrrolidine derivatives as bax inhibitors
    摘要:
    本发明涉及新的取代吡咯烷衍生物的化学式(I)。所述化合物通常用作药用活性化合物。具体来说,化学式(I)的吡咯烷衍生物在治疗和/或预防神经退行性疾病、与多谷氨酸氨基酸序列相关的疾病、癫痫、缺血、不孕症、心血管疾病、肾脏缺氧、肝炎和艾滋病方面具有用处。所述吡咯烷衍生物显示出对细胞死亡促进子Bax和/或导致Bax激活途径的调节作用,最显著地是下调至抑制活性,并因此允许阻止细胞色素(c)的释放。本发明还涉及新的具有药用活性的取代吡咯烷衍生物,以及它们的制备方法,其中X选自O、S、CR<6>R<7>、NOR<6>、NNR<6>R<7>组成的群;A选自—(C═O)—、—(C═O)—O—、—C(═NH)—、—(C═O)—NH—、—(C═S)—NH、—SO2-、—SO2NH—;—CH2-;B是一个群—(C═O)—NR<8>R<9>或代表具有化学式(II)的杂环残基,其中Q是NR<10>、O或S;n是选自0、1或2的整数;Y、Z和E与它们连接的两个碳共同形成一个5-6成员芳香族或杂芳族环。
    公开号:
    US20030171309A1
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文献信息

  • Endothelin antagonists
    申请人:Abbott Laboratories
    公开号:US06162927A1
    公开(公告)日:2000-12-19
    A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
    公开了一种具有以下化学式(I)的化合物:##STR1##或其药用可接受的盐,以及制备该化合物的方法、中间体,以及一种拮抗内皮素的方法。
  • Isoquinolones
    申请人:Warner-Lambert Company
    公开号:US06177423B1
    公开(公告)日:2001-01-23
    Benzo[de]isoquinoline-1,3-dione of Formula or a pharmaceutically acceptable salt thereof wherein R is hydrogen or a protecting group typically used in the art for protecting alcohols and R1-R5 are each independently chosen from H, Cl, Br, F, straight or branched alkyl C1-C8 alkyl, C3-C8 cycloalkyl, heterocycle or bridged heterocycle of 4-9 atoms containing 1-3 heteroatoms, —(CR′2)nOR6, —(CR′2)nN(R6)2, —(CR′2)nNR6COR7, —(CR′2)nNR6SO2OR7, —(CR′2)nNR6SO2 N(R6)2, —(CR′2)nOSO2 N(R6)2, —(CR′2)nCN, —(CR′2)n(NOR6)R7, NO2, CF3, —(CR′2)nSOmR7, —(CR′2)nSOmR7, —(CR′2)nCO2R6, —(CR′2)nCON(R6)2, Ph, and any two of R1-R5 may form a substituted or unsubstituted ring of 5-7 total atoms having 0-2 heteroatoms are claimed which are selective inhibitors of bacterial DNA gyrase and DNA topoisomerase useful in antibacterial agents. Methods for their preparation and formulation as well as novel intermediates useful in the preparation of the final products are also claimed.
    苯并[de]异喹啉-1,3-二酮的化学式,或其在药学上可接受的盐,其中R为氢或通常用于保护醇的艺术中的保护基,R1-R5分别独立地选择自H、Cl、Br、F、直链或支链烷基C1-C8烷基、C3-C8环烷基、杂环或含有1-3个杂原子的4-9个原子的桥接杂环,—(CR′2)nOR6、—(CR′2)nN(R6)2、—(CR′2)nNR6COR7、—(CR′2)nNR6SO2OR7、—(CR′2)nNR6SO2 N(R6)2、—(CR′2)nOSO2 N(R6)2、—(CR′2)nCN、—(CR′2)n(NOR6)R7、NO2、CF3、—(CR′2)nSOmR7、—(CR′2)nSOmR7、—(CR′2)nCO2R6、—(CR′2)nCON(R6)2、Ph,以及R1-R5中的任意两个可形成具有0-2个杂原子的5-7个总原子的取代或未取代环的选择性细菌DNA旋转酶和DNA拓扑异构酶抑制剂,适用于抗菌剂。还声明了它们的制备和配方方法,以及在制备最终产品中有用的新型中间体。
  • Azabicyclo and azacyclo oxime and amine cholinergic agents and methods
    申请人:Warner-Lambert Company
    公开号:US05346911A1
    公开(公告)日:1994-09-13
    Pharmaceutically useful nitrogen containing cyclic oxime and amine substituted compounds which are azabicyclo[2.2.1]oximes, azabicyclo[2.2.2]oximes, azabicyclo[2.2.1]amines, azabicyclo[2.2.2]amines, azabicyclo[3.2.1]oximes, and amine containing heterocyclic oximes wherein the heterocyclic ring contains from 3 to 7 carbon atoms are disclosed.
    本专利涉及一种在药物上有用的含氮环氧肟和胺取代化合物,这些化合物是氮杂双环[2.2.1]氧肟、氮杂双环[2.2.2]氧肟、氮杂双环[2.2.1]胺、氮杂双环[2.2.2]胺、氮杂三环[3.2.1]氧肟,以及含有3至7个碳原子的杂环氧肟的胺。
  • Azabicycloalkane oxime & azabicycloalkene oxime muscarinic agents
    申请人:Warner-Lambert Company
    公开号:US04937239A1
    公开(公告)日:1990-06-26
    Novel 1-azabicycloalkane- and alkene-oximes (Ia) and 8-azabicyclo[3.2.1]octane- and octene-oximes (Ib) are provided, these compounds being useful as agents for treating pain or for treating the symptoms of senile cognitive decline. Also provided are pharmaceutical compositions containing the compounds and methods of treatment using the compounds in dosage form. ##STR1##
    提供了小说1-氮杂双环烷和烯氧肟(Ia)以及8-氮杂双环[3.2.1]辛烷和辛烯氧肟(Ib),这些化合物可用作治疗疼痛或治疗老年认知衰退症状的药物。还提供了含有这些化合物的药物组合物以及使用这些化合物的剂型进行治疗的方法。
  • Pyrrolidine oxadiazole-and thiadiazole derivatives
    申请人:——
    公开号:US20040220238A1
    公开(公告)日:2004-11-04
    The present invention is related to pyrrolidine oxadiazole and thiadiazole derivatives for use as pharmaceutically active compounds, as well as pharmaceutical formulations containing such pyrrolidine oxadiazole derivatives. Said pyrrolidine derivatives are useful in the treatment and/or prevention of preterm labor, premature birth and dysmenorrhea. In particular, the present invention is related to pyrrolidine derivatives displaying a substantial modulatory, notably an antagonist activity of the oxytocin receptor. More preferably, said compounds are useful in the treatment and/or prevention of disease states mediated by oxytocin, including preterm labor, premature birth and dysmenorrhea. The present invention is furthermore related to novel pyrrolidine derivatives as well as to methods of their preparation. (I) B is a oxadiazole or thiadiazole group. 1
    本发明涉及吡咯烷氧二唑和噻二唑衍生物,用作药物活性化合物,以及含有此类吡咯烷氧二唑衍生物的制药配方。所述吡咯烷衍生物在治疗和/或预防早产、早产和痛经方面具有用途。特别地,本发明涉及显示出显著调节活性,特别是催产素受体拮抗剂活性的吡咯烷衍生物。更具体地,这些化合物在治疗和/或预防由催产素介导的疾病状态方面具有用途,包括早产、早产和痛经。本发明还涉及新型吡咯烷衍生物及其制备方法。(I) B是氧代二唑或噻二唑基团。
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