exo-Norborneol | 1217516-17-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: exo-Norborneol
• 英文别名: Isonorborneol；(2R)-bicyclo[2.2.1]heptan-2-ol
• CAS: 1217516-17-0
• 化学式: C₇H₁₂O
• 分子量: 112.172
• InChiKey: ZQTYQMYDIHMKQB-KPGICGJXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  exo-Norborneol 以49%的产率得到
  参考文献：
  名称：

  Shine Henry J., Yueh Wang, J. Org. Chem, 59 (1994) N 13, S 3553-3559

  摘要：

  DOI：
• 作为产物：
  描述：

  降樟脑 生成 exo-Norborneol
  参考文献：
  名称：

  MIDLAND, M. MARK;MCLOUGHLIN, JIM I.;GABRIEL, JOSEF, J. ORG. CHEM., 54,(1989) N, C. 159-165

  摘要：

  DOI：

文献信息

• Androgen modulators
  申请人：Hu Lain-Yen

  公开号：US20060009427A1

  公开（公告）日：2006-01-12

  The present invention is directed to a new class of 4-cycloalkoxy benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.

  本发明涉及一种新型的4-环烷氧基苯甲腈类化合物，以及它们作为雄激素受体调节剂的用途。本发明的其他方面涉及使用这些化合物来减少多余的皮脂分泌并刺激头发生长。
• METHOD FOR SYNTHESIS OF HALOPYRIDYL-ACYCLOPENTANE DERIVATIVE AND INTERMEDIATE THEREOF
  申请人：——

  公开号：US20020010339A1

  公开（公告）日：2002-01-24

  The present invention relates to a method for synthesis of an optically active halopyridyl-azacyclo-pentane derivative and the intermediate thereof which comprises preparing an optically active allene-1,3-dicarboxylic acid ester derivative from an optically active acetonedicarboxylic acid ester derivative and then proceeding through a 7-azabicyclo[2.2.1]heptane derivative to obtain the objective product.

  本发明涉及一种合成光学活性卤代吡啶-氮杂环戊烷衍生物及其中间体的方法，包括从光学活性丙酮二羧酸酯衍生物制备光学活性联二烯-1,3-二羧酸酯衍生物，然后通过7-氮杂双环[2.2.1]庚烷衍生物进行反应，以获得目标产物。
• Processes and intermediates in the synthesis of 5-(3-{exo-bicyclo{2.2.1}hept-2-yloxy]-4-methoxyphenyl)-3,4,5,6- tetrahydropyrimidin-2(1H)-one
  申请人：——

  公开号：US20010041798A1

  公开（公告）日：2001-11-15

  This invention relates to novel processes for preparing the pharmaceutically active compound 5-(3-[(2S)-exo-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one and its corresponding 2R enantiomer and for preparing certain intermediates used in the synthesis of these compounds. It also relates to novel intermediates used in the synthesis of such pharmaceutically active compounds and to other novel compounds that are related to such intermediates.

  本发明涉及制备药用活性化合物5-(3-[(2S)-exo-双环[2.2.1]庚-2-氧基]-4-甲氧基苯基)-3,4,5,6-四氢嘧啶-2(1H)-酮及其对应的2R对映体的新型制备工艺，并制备了用于合成这些化合物的某些中间体。本发明还涉及用于合成这种药物活性化合物的新型中间体和与这些中间体相关的其他新型化合物。
• ANDROGEN MODULATORS
  申请人：Hu Lain-Yen

  公开号：US20100048517A1

  公开（公告）日：2010-02-25

  The present invention is directed to a new class of 4-cycloalkoxy benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.

  本发明涉及一种新的4-环烷氧基苯甲腈类化合物，以及它们作为雄激素受体调节剂的用途。本发明的其他方面涉及使用这些化合物来减少多余的皮脂分泌和刺激头发生长。
• <i>S</i>-<i>endo</i>-2-Norbornyl-<i>N</i>-<i>n</i>-butylcarbamate as a Potential<i>Pseudomonas</i>Lipase Inhibitor to Probe the Enantioselectivity of the Enzyme by Kinetic and Molecular Docking Evaluation
  作者：Yu-Fang Shen、Gan-Hong Chen、Shu-Hsien Lin、Gialih Lin

  DOI：10.1002/jccs.201600005

  日期：2016.8

  Previous studies reported that lipase is a main target for obesity treatment. We synthesized R‐exo‐2‐norbornyl‐N‐n‐butylcarbamate and S‐exo‐2‐norbornyl‐N‐n‐butylcarbamate as potential pseudomonas lipase inhibitors to probe the enantioselectivity of the enzyme and demonstrated that R‐exo‐2‐norbornyl‐N‐n‐butylcarbamate had better enzyme enantioselectivity, ki and the docking model with Pseudomonas species

  肥胖是一个复杂的健康问题，它可能导致许多健康和社会问题。先前的研究报道脂肪酶是肥胖症治疗的主要目标。我们合成了[R -外型-2- norbornyl- ñ - ñ -butylcarbamate和小号-外型-2- norbornyl- ñ - ñ -butylcarbamate作为脂肪酶抑制剂潜在假单胞菌探测酶的对映选择性，并证明了[R -外型-2- norbornyl- ñ - ñ -butylcarbamate最好酶的对映选择性，き和与对接模型假单胞菌我们以前的研究中的种脂肪酶。在本文中，我们报道了的属性假单胞菌物种脂肪酶抑制剂，- [R -和小号-内-2- norbornyl- ñ - ñ -butylcarbamate并与这两种化合物的对接模型- [R -和小号-外型-2- norbornyl- ñ - ñ通过AUTODOCK -butylcarbamates。我们发现，小号-内-2-

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