benzyl 4-methylcinnamate | 1309761-78-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: benzyl 4-methylcinnamate
• 英文别名: Benzyl 3-(4-methylphenyl)prop-2-enoate
• CAS: 1309761-78-1
• 化学式: C₁₇H₁₆O₂
• 分子量: 252.313
• InChiKey: IUMFLPGAYJAXCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  benzyl 4-methylcinnamate 、 4-methyl-N-(pent-4-yn-1-yl)benzenesulfonamide 在 gallium(III) triflate 、 dimethylsulfide gold(I) chloride 作用下， 以 甲苯 为溶剂， 反应 1.5h， 以81.818%的产率得到
  参考文献：
  名称：

  Synthesis of Fused Bicyclic Aminals through Sequential Gold/Lewis Acid Catalysis

  摘要：

  A novel sequential catalysis by combining gold catalysis with early transition metal catalysis was developed. Biologically important bicyclo[4.n.0] aminals were obtained under very mild conditions.

  DOI：

  10.1021/ol400803f
• 作为产物：
  描述：

  4-碘甲苯 、 丙烯酸苄酯 在 palladium diacetate 、 potassium carbonate 、 抗氧剂 RC PEP 36 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以87%的产率得到benzyl 4-methylcinnamate
  参考文献：
  名称：

  比色高通量筛选方法的金纳米粒子为基础的碘化物选择性探针用于钯催化的碘化物偶合反应。

  摘要：

  捕获偶联剂：钯催化的芳基碘化物偶联反应的通用且简单的筛选方法是利用金纳米颗粒。该测定法已成功用于多种胺化反应，酮的α芳基化反应和脱羧偶联反应。几分钟内筛选出96个样品。

  DOI：

  10.1002/anie.201100378

文献信息

• Highly efficient and green esterification of carboxylic acids in deep eutectic solvents without any other additives
  作者：Sumera Yasmin、Wen-Bing Sheng、Cai-Yun Peng、Atta-ur Rahman、Duan-Fang Liao、M. Iqbal Choudhary、Wei Wanga

  DOI：10.1080/00397911.2017.1390138

  日期：2018.1.2

  ABSTRACT A protocol that carboxylic acids esterifies with the quaternary ammonium salt of deep eutectic solvent (DES) is presented, which opens a new access to ester using DES as alkylating agent, solvent, and catalyst. The reaction runs smoothly in DES without any other additives. Substituted cinnamic acids, aromatic acids, and aliphatic acids can be esterified in moderate to good yields. The advantages

  摘要提出了一种羧酸与深共熔溶剂 (DES) 的季铵盐进行酯化的协议，它开辟了使用 DES 作为烷化剂、溶剂和催化剂获得酯的新途径。反应在 DES 中顺利进行，无需任何其他添加剂。取代的肉桂酸、芳香酸和脂肪酸可以以中等至良好的收率进行酯化。该反应的优点是官能团相容性好，反应过程简单。图形概要
• Natural sunscreen compositions and processes for producing the same
  申请人：Mitra Kumar Shankar

  公开号：US20080095721A1

  公开（公告）日：2008-04-24

  Disclosed is a natural sunscreen composition comprising extracts of Hedychium spicatum and/or Alpinia galanga containing active sunscreen agents, the sunscreen composition devised to protect the skin from the harmful effects of short wavelength UV B rays and long wavelength UV A rays.
• US7311896B2
  申请人：——

  公开号：US7311896B2

  公开（公告）日：2007-12-25
• A Colorimetric High-Throughput Screening Method for Palladium-Catalyzed Coupling Reactions of Aryl Iodides Using a Gold Nanoparticle-Based Iodide-Selective Probe
  作者：Eunhye Jung、Sudeok Kim、Yong Kim、Seong Hyeok Seo、Soo Suk Lee、Min Su Han、Sunwoo Lee

  DOI：10.1002/anie.201100378

  日期：2011.5.2

  Catching the couplings: A general and simple screening method for palladium‐catalyzed coupling reactions of aryl iodides utilizes gold nanoparticles. This assay was successfully employed in several aminations, α‐arylation of ketones, and decarboxylative couplings. 96 samples were screened in a few minutes.

  捕获偶联剂：钯催化的芳基碘化物偶联反应的通用且简单的筛选方法是利用金纳米颗粒。该测定法已成功用于多种胺化反应，酮的α芳基化反应和脱羧偶联反应。几分钟内筛选出96个样品。
• Synthesis of Fused Bicyclic Aminals through Sequential Gold/Lewis Acid Catalysis
  作者：Xianghua Wang、Zhili Yao、Shuli Dong、Fang Wei、Hong Wang、Zhenghu Xu

  DOI：10.1021/ol400803f

  日期：2013.5.3

  A novel sequential catalysis by combining gold catalysis with early transition metal catalysis was developed. Biologically important bicyclo[4.n.0] aminals were obtained under very mild conditions.