2-amino-1,4-dimethoxyacridone | 292068-48-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-amino-1,4-dimethoxyacridone
• 英文别名: 2-amino-1,4-dimethoxy-10H-acridin-9-one
• CAS: 292068-48-5
• 化学式: C₁₅H₁₄N₂O₃
• 分子量: 270.288
• InChiKey: MIFOOCPXFLLYPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  73.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-amino-1,4-dimethoxyacridone 在 2,6-二甲基吡啶 、 4-二甲氨基吡啶 、 tris(dibenzylideneacetone)dipalladium(0) chloroform complex 、 二乙醇胺 、 三苯基膦 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 25.0h， 生成 2-acetylamino-1,4-dimethoxy-9-(trimethylsilylethynyl)acridine
  参考文献：
  名称：

  Preparation of New Pyridoacridine Derivatives and Formal Synthesis of 11-Hydroxyascididemine

  摘要：

  The preparation of pyrido[2,3,4-kl]acridin-6-ones substituted at position 4 following our previous methodology is described. A new synthetic route for the preparation of aminopyridoacridone 16, used before for the synthesis of the 11-hydroxyascididemine, is described. The cytotoxic activity of pyridoacridones 19 and 20 in four cell lines is reported. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00251-9
• 作为产物：
  描述：

  1,4-dimethoxy-2-nitroacridone 在 sodium tetrahydroborate 、 nickel dichloride 作用下， 以 甲醇 为溶剂， 以78%的产率得到2-amino-1,4-dimethoxyacridone
  参考文献：
  名称：

  Preparation of New Pyridoacridine Derivatives and Formal Synthesis of 11-Hydroxyascididemine

  摘要：

  The preparation of pyrido[2,3,4-kl]acridin-6-ones substituted at position 4 following our previous methodology is described. A new synthetic route for the preparation of aminopyridoacridone 16, used before for the synthesis of the 11-hydroxyascididemine, is described. The cytotoxic activity of pyridoacridones 19 and 20 in four cell lines is reported. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00251-9

文献信息

• Preparation of New Pyridoacridine Derivatives and Formal Synthesis of 11-Hydroxyascididemine
  作者：Mercedes Álvarez、Lidia Feliu、Wadi Ajana、John A Joule

  DOI：10.1016/s0040-4020(00)00251-9

  日期：2000.6

  The preparation of pyrido[2,3,4-kl]acridin-6-ones substituted at position 4 following our previous methodology is described. A new synthetic route for the preparation of aminopyridoacridone 16, used before for the synthesis of the 11-hydroxyascididemine, is described. The cytotoxic activity of pyridoacridones 19 and 20 in four cell lines is reported. (C) 2000 Elsevier Science Ltd. All rights reserved.