1-(2-chloroquinolin-3-yl)-N-propan-2-ylmethanimine | 1421699-08-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(2-chloroquinolin-3-yl)-N-propan-2-ylmethanimine
• CAS: 1421699-08-2
• 化学式: C₁₃H₁₃ClN₂
• 分子量: 232.713
• InChiKey: CJWURAOICUUIEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  25.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  叔丁基氰基二甲基硅烷 、 1-(2-chloroquinolin-3-yl)-N-propan-2-ylmethanimine 在 水 作用下， 以 乙腈 为溶剂， 以83%的产率得到2-(2-Chloroquinolin-3-yl)-2-(propan-2-ylamino)acetonitrile
  参考文献：
  名称：

  Efficient synthesis and X-ray structures of new α-quinolin-3-yl-α-aminonitriles and derivatives

  摘要：

  This study describes the synthesis of novel alpha-aminonitrile derivatives possessing a quinoline subunit via a Strecker reaction. Chiral alpha-methylbenzylamines were used to carry out the diastereoselective version of this sequence. Conversion of an enantiopure 2-chloroquinolin-3-yl derivative into the corresponding alpha-aminoester resulted in the concomitant formation of a 2(1H)-quinolinone moiety and a partial racemization. Single crystal X-ray structures are reported for three compounds. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.11.032
• 作为产物：
  描述：

  2-氯-3-喹啉甲醛 、 异丙胺 以 甲醇 为溶剂， 以90%的产率得到1-(2-chloroquinolin-3-yl)-N-propan-2-ylmethanimine
  参考文献：
  名称：

  Efficient synthesis and X-ray structures of new α-quinolin-3-yl-α-aminonitriles and derivatives

  摘要：

  This study describes the synthesis of novel alpha-aminonitrile derivatives possessing a quinoline subunit via a Strecker reaction. Chiral alpha-methylbenzylamines were used to carry out the diastereoselective version of this sequence. Conversion of an enantiopure 2-chloroquinolin-3-yl derivative into the corresponding alpha-aminoester resulted in the concomitant formation of a 2(1H)-quinolinone moiety and a partial racemization. Single crystal X-ray structures are reported for three compounds. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.11.032