Nea-Eda | 1147343-69-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Nea-Eda
• 英文别名: epi-5-[(2-aminoethyl)amino]-5-deoxyneamine；epi-5-N(aminoethyl)neamine
• CAS: 1147343-69-8
• 化学式: C₁₄H₃₂N₆O₅
• 分子量: 364.445
• InChiKey: WIVYQMIHJJJGFZ-VOMQWEQLSA-N

物化性质

• 沸点：
  640.3±55.0 °C(predicted)
• 密度：
  1.40±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -5.56
• 重原子数：
  25.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  221.28
• 氢给体数：
  9.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  Nea-Eda 、 三氟乙酸 以 水 为溶剂， 以33 mg的产率得到
  参考文献：
  名称：

  Synthesis and evaluation of novel neamine derivatives effectively targeting to RNA

  摘要：

  Three new derivatives of neamine, 3 (NE), 6 (NEA) and 9 (NEL), were synthesized by connecting arginine or lysine to 5-hydroxyl group of neamine using ethylenediamine as a linker. The binding affinities of these derivatives to A site of 16S RNA and TAR RNA indicate that the modi. cation on 5-hydroxyl of neamine by amino acid can enhance the binding affinity of neamine. Compound 9 (NEL) shows some antibacterial activities. These results demonstrate that modi. cation on 5-hydroxyl group of neamine may provide a promising way for the development of potential candidates effectively targeting to RNAs. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.03.021
• 作为产物：
  描述：

  5-O-triflyl-1,3,2',6'-tetraazido-6,3',4'-tri-O-benzylneamine 在 palladium on activated charcoal 、 水 、 氢气 、 三苯基膦 作用下， 以 四氢呋喃 、 水 、 溶剂黄146 、 乙腈 为溶剂， 反应 96.0h， 生成 Nea-Eda
  参考文献：
  名称：

  Neamine-heterocycle conjugates as potential anti-HIV agents

  摘要：

  A series of neamine-heterocycle conjugates were designed and synthesized. All new compounds displayed more potent inhibitory effect on HIV replication than neamine, among them two compounds displayed stronger anti-HIV activity than neomycin B. The results suggested that it might be a promising approach to modify neamine for the discovery of new anti-HIV agents. (C) 2013 Xiao-Lian Zhang, Xin-Shan Ye. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.03.009