5-(1H-imidazol-1-yl)-2-isopropoxybenzaldehyde | 1210502-10-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(1H-imidazol-1-yl)-2-isopropoxybenzaldehyde
• CAS: 1210502-10-5
• 化学式: C₁₃H₁₄N₂O₂
• 分子量: 230.266
• InChiKey: CYRPAQJVJRRONF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.47
• 重原子数：
  17.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  44.12
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  5-(1H-imidazol-1-yl)-2-isopropoxybenzaldehyde 、 甲基三苯基溴化膦 在 lithium hexamethyldisilazane 作用下， 以 替加氟 为溶剂， 反应 12.0h， 以86%的产率得到1-(3-Ethenyl-4-propan-2-yloxyphenyl)imidazole
  参考文献：
  名称：

  Acid-mediated activation of modified ring-closing metathesis catalysts

  摘要：

  To improve the reactivity of Grubbs catalyst, novel ligands were designed and synthesized which possess nitrogen-containing heterocycles such as imidazole and pyridine. The modified catalysts were treated with a range of acids and the acid salt forms were used as catalysts for ring-closing metathesis (RCM) reactions. As a result, reactions employing the acid-modified catalysts showed considerable reactivity enhancement in RCM. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.11.112
• 作为产物：
  描述：

  咪唑 、 5-溴-2-(1-甲基乙氧基)苯甲醛 在 copper(l) iodide 、 四甲基乙二胺 、 caesium carbonate 作用下， 反应 48.0h， 以87%的产率得到5-(1H-imidazol-1-yl)-2-isopropoxybenzaldehyde
  参考文献：
  名称：

  Acid-mediated activation of modified ring-closing metathesis catalysts

  摘要：

  To improve the reactivity of Grubbs catalyst, novel ligands were designed and synthesized which possess nitrogen-containing heterocycles such as imidazole and pyridine. The modified catalysts were treated with a range of acids and the acid salt forms were used as catalysts for ring-closing metathesis (RCM) reactions. As a result, reactions employing the acid-modified catalysts showed considerable reactivity enhancement in RCM. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.11.112