(+)-3-(aminomethyl)-pinane | 61299-72-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (+)-3-(aminomethyl)-pinane
• 英文别名: (-)-3-Pinane-methylamine；Bicyclo[3.1.1]heptane-3-methanamine, 2,6,6-trimethyl-；(2,6,6-trimethyl-3-bicyclo[3.1.1]heptanyl)methanamine
• CAS: 61299-72-7
• 化学式: C₁₁H₂₁N
• 分子量: 167.294
• InChiKey: MUOITVAMHSVXLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  benzyl-bromo-ethenyl-diphenyl-λ5-phosphane 、 (+)-3-(aminomethyl)-pinane 以83%的产率得到
  参考文献：
  名称：

  HORNER, L.;DICHERHOF, K., PHOSPH. AND SULFUR, 1983, 15, N 3, 331-349

  摘要：

  DOI：
• 作为产物：
  描述：

  2,6,6-三甲基二环[3.3.1]庚烷-3-羧醛 、 钴 在 氨 作用下， 以 乙醇 为溶剂， 生成 (+)-3-(aminomethyl)-pinane
  参考文献：
  名称：

  Resolution of racemic pantolactone

  摘要：

  一种用于将混合的α-羟基-β,β-二甲基-γ-丁内酯（也称为D，L-泛酸内酯）分离为其光学对映体的方法，基于通过使用（-）-3-氨甲基蒎烷，（+）-3-氨甲基蒎烷或它们的酸盐加成物从D，L-泛酸内酯生成的D，L-泛酸（α，γ-双羟基-β，β-二甲基丁酸）的对映异构体盐的分离，作为一种新的分离剂。

  公开号：

  US03996246A1

文献信息

• Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes
  申请人：3-Dimensional Pharmaceuticals, Inc.

  公开号：US20030105111A1

  公开（公告）日：2003-06-05

  The present invention is directed to a compound of Formula I: 1 wherein A, R 1 , and R 2 are defined herein. The present invention is also directed to compositions comprising compounds of Formula I, methods of using compounds of Formula I, and methods of making compounds of Formula I.

  本发明涉及一种具有以下结构的化合物：其中A、R1和R2在此处被定义。本发明还涉及包含Formula I化合物的组合物、使用Formula I化合物的方法以及制备Formula I化合物的方法。
• 6H-oxazolo[4,5-e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands
  申请人：Schiemann Kai

  公开号：US20050101649A1

  公开（公告）日：2005-05-12

  Compounds of the formula I in which R 1 , R 2 , R 3 and R 4 are as defined in claim 1, are ligands of the nicotinic acetylcholine receptor and/or serotonergic ligands and are suitable for the prophylaxis or treatment of psychoses, schizophrenia, depression, anxiety states, dementia, in particular Alzheimer's disease and Lewy bodies dementia, neurodegenerative disorders, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, Tourette's syndrome, learning and memory restrictions, bulimia anorexia nervosa or other eating disorders, compulsvie behaviour, premenstrual syndrome, age-induced memory impairment, amelioration of withdrawal symptoms in nicotine dependence, strokes or brain damage by toxic compounds, and for the treatment of disorders which are characterised by an excess of circulating serotonin or by serotonergic hyperactivity.

  公式I中的化合物，其中R1、R2、R3和R4如权利要求1所定义，是尼古丁乙酰胆碱受体和/或血清素配体的配体，适用于预防或治疗精神病、精神分裂症、抑郁症、焦虑状态、痴呆症，特别是阿尔茨海默病和Lewy小体痴呆、神经退行性疾病、帕金森病、肌萎缩性侧索硬化症、亨廷顿病、图雷特综合症、学习和记忆限制、暴食症厌食症或其他进食障碍、强迫行为、经前期综合症、年龄引起的记忆障碍、改善尼古丁依赖的戒断症状、中毒化合物引起的中风或脑损伤，并用于治疗其特征为循环血清素过多或血清素活性过高的疾病。
• Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases
  申请人：NPS PHARMACEUTICALS, INC.

  公开号：US20030013715A1

  公开（公告）日：2003-01-16

  The present invention provides compounds, and pharmaceutical compositions containing those compounds, that are active at metabotropic glutamate receptors. The compounds are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.

  本发明提供了一种在代谢型谷氨酸受体上具有活性的化合物和含有这些化合物的药物组合物，这些化合物对治疗神经系统疾病和紊乱有用。本发明还公开了制备这些化合物的方法。
• Regeneration of 6-fluoro-4-chromanone from by-products in the synthesis
  申请人：Pfizer Inc.

  公开号：US04431828A1

  公开（公告）日：1984-02-14

  6-Fluoro-4-chromanone, a sorbinil intermediate, is regenerated from enantiomeric and mixtures of enantiomeric and racemic compounds obtained as major by-products in the synthesis of sorbinil. The regenerated intermediate is useful in the synthesis of additional sorbinil.

  6-氟-4-香豆酮是索比尼尔的中间体，可以从合成索比尼尔的主要副产物中获得的对映体和对映体与外消旋化合物的混合物中再生。再生的中间体在合成额外索比尼尔方面非常有用。
• Process for preparing optically active hydantoins
  申请人：Sanwa Kagaku Kenkyyusho Co., Ltd.

  公开号：US05001240A1

  公开（公告）日：1991-03-19

  Hydantoin derivatives and salts thereof, intermediates therefor, process for the preparation thereof, and medicines containing the derivatives, wherein said derivatives have the formula ##STR1## wherein one of V and W is hydrogen and the other is a halogenomethyl group, 1H-tetrazol-5-yl radical, --COOR group, in which R is hydrogen atom, an alkyl group, --(CH.sub.2 CH.sub.2 O)nCH.sub.3 group (n is an integer of 1 to 113) or substituted phenyl, ##STR2## group, in which R.sub.1 and R.sub.2 are same or different independently, each is hydrogen atom, an alkyl group, substituted phenyl or --(CH.sub.2 CH.sub.2 O)nCH.sub.3 group (n has the meaning as referred to) or R.sub.1 may form a heterocyclic ring together with R.sub.2 and nitrogen or oxygen atom, --CH.sub.2 OR.sub.3 group or ##STR3## group, in which R.sub.3 and R.sub.4 are same or different independently and each is hydrogen atom or an alkyl group, X is oxygen or sulfur atom, and Y and Z are same or different independently and each is hydrogen atom, a halogen atom, alkyl group, alkoxy group, alkylmercapto group, nitro radical or --NHR.sub.5 group, in which R.sub.5 is hydrogen atom or an acyl group. The derivatives and salts thereof are useful for the treatment of complications of diabetes.

  含肟类衍生物及其盐、其中间体、其制备方法和含有该衍生物的药物，其中所述衍生物具有以下式子：##STR1## 其中V和W中的一个为氢，另一个为卤代甲基基团、1H-四唑-5-基基团、--COOR基团，其中R为氢原子、烷基、--(CH.sub.2 CH.sub.2 O)nCH.sub.3基团（n为1至113的整数）或取代苯基，##STR2##基团，其中R.sub.1和R.sub.2各自独立地相同或不同，每个为氢原子、烷基、取代苯基或--(CH.sub.2 CH.sub.2 O)nCH.sub.3基团（n的含义如上所述），或R.sub.1可以与R.sub.2和氮或氧原子一起形成杂环环，--CH.sub.2 OR.sub.3基团或##STR3##基团，其中R.sub.3和R.sub.4各自独立地相同或不同，每个为氢原子或烷基，X为氧或硫原子，Y和Z各自独立地相同或不同，每个为氢原子、卤原子、烷基、烷氧基、烷基硫基、硝基基团或--NHR.sub.5基团，其中R.sub.5为氢原子或酰基。该衍生物及其盐对糖尿病并发症的治疗有用。