5-Hydroxy-2-(4-methoxy-phenyl)-imidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester | 484691-31-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-Hydroxy-2-(4-methoxy-phenyl)-imidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester
• CAS: 484691-31-8
• 化学式: C₁₆H₁₅N₃O₄
• 分子量: 313.313
• InChiKey: LBZIFIPXAKJBPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.29
• 重原子数：
  23.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  85.95
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  5-Hydroxy-2-(4-methoxy-phenyl)-imidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester 在 四丁基氟化铵 、 溶剂黄146 作用下， 以 四氢呋喃 、 乙二醇二甲醚 为溶剂， 反应 2.5h， 生成 8-(2-Fluoro-benzyl)-2-(4-methoxy-phenyl)-3-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-5-oxo-5,8-dihydro-imidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester
  参考文献：
  名称：

  Synthesis and initial structure–Activity relationships of a novel series of imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists

  摘要：

  SAR studies of 2-arylimidazolo[1,2-a]pyrimid-5-ones 10a-m, which were derived from initial lead 3a, resulted in the discovery of a series of potent nonpeptide human GnRH receptor antagonists. Compounds with good potency (e.g., 10e, K-i = 7.5 nM) were prepared by introduction of a 2-(2-pyridyl)ethyl at the basic nitrogen and a 3-pentyl ester at the 6-position of the bicyclic core. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00370-0
• 作为产物：
  描述：

  2-氨基-5-乙氧羰基-4-羟基嘧啶 、 alpha-溴-4-甲氧基苯乙酮 在 sodium hydride 作用下， 以 乙二醇二甲醚 为溶剂， 反应 1.5h， 生成 5-Hydroxy-2-(4-methoxy-phenyl)-imidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester
  参考文献：
  名称：

  Synthesis and initial structure–Activity relationships of a novel series of imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists

  摘要：

  SAR studies of 2-arylimidazolo[1,2-a]pyrimid-5-ones 10a-m, which were derived from initial lead 3a, resulted in the discovery of a series of potent nonpeptide human GnRH receptor antagonists. Compounds with good potency (e.g., 10e, K-i = 7.5 nM) were prepared by introduction of a 2-(2-pyridyl)ethyl at the basic nitrogen and a 3-pentyl ester at the 6-position of the bicyclic core. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00370-0