3-溴-2-氧代樟脑烷-8-磺酸铵 | 74165-69-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 3-溴-2-氧代樟脑烷-8-磺酸铵
• 英文名称: ammonium bromocamphorsulfonate
• 英文别名: ammonium (+)-3-bromocamphor-8-sulfonate；d-3-bromocamphor-9-sulfonic acid ammonium salt；ammonium L(-)-3-bromocamphor-8-sulphonate；(+)-3-bromocamphor-8-sulfonic acid ammonium salt；(+)-ammonium 3-bromo-camphor-9-sulphonate；Ammonium 3-bromo-2-oxobornane-8-sulphonate；azane;(3-bromo-1,7-dimethyl-2-oxo-7-bicyclo[2.2.1]heptanyl)methanesulfonic acid
• CAS: 74165-69-8
• 化学式: C₁₀H₁₄BrO₄S*H₄N
• 分子量: 328.227
• InChiKey: GFBVBBRNPGPROZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.68
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  83.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  消旋达泊西汀游离碱 、 3-溴-2-氧代樟脑烷-8-磺酸铵 以 甲醇 、 乙酸乙酯 为溶剂， 生成 (+)-N,N-Dimethyl-1-phenyl-3-(1-naphthalenyloxy) propanamine (+)-3-bromocamphor-8-sulfonate
  参考文献：
  名称：

  1-phenyl-3-naphthalenyloxypropanamines and their use as selective

  摘要：

  本发明提供了1-苯基-3-萘氧丙胺，它们是选择性的血清素再摄取抑制剂。

  公开号：

  US05135947A1

文献信息

• [EN] RESOLUTION OF MEFLOQUINE WITH O,O-DI-P-AROYLTARTARIC ACID<br/>[FR] RESOLUTION DE MEFLOQUINE AVEC DE L'ACIDE O,O-DI-P-AROYLTARTARIQUE
  申请人：ARAKIS LTD

  公开号：WO2004050625A1

  公开（公告）日：2004-06-17

  A process for increasing the optical purity of a mixture of enantiomers of mefloquine, used a substantially single enantiomer of a O, O-di-p-aroyltartaric acid as a resolving agent.

  一种用于增加美氟喹对映体混合物的光学纯度的方法，使用了一种基本上单一对映体的O，O-二对苯二甲酰酒石酸作为分离剂。
• METHOD FOR PREPARING D-ARGININE
  申请人：AMINOLOGICS CO., LTD.

  公开号：US20180354896A1

  公开（公告）日：2018-12-13

  This invention relates to a method of preparing D-arginine, and more particularly to a method of preparing D-arginine by optically resolving DL-arginine using D-3-bromocamphor-8-sulfonic acid or a salt thereof as an optical resolving agent.

  本发明涉及一种制备D-精氨酸的方法，更具体地涉及使用D-3-溴基樟脑-8-磺酸或其盐作为光学分辨剂来对DL-精氨酸进行光学分辨制备D-精氨酸的方法。
• Optical resolution of<scp>DL</scp>-2,2′-bipiperidine through its cobalt(<scp>III</scp>) complex
  作者：Mitsunobu Sato、Yoichi Sato、Shigenobu Yano、Sadao Yoshikawa

  DOI：10.1039/dt9850000895

  日期：——

  The separation of racemic 2,2′-bipiperidine and the meso form has been performed through the dihydrochloride salt of the diamine. The reaction of racemic 2,2′-bipiperidine with [Co(NO2)6]3– has been shown to yield only one DL pair of trans-bis(2,2′-bipiperidine)dinitrocobalt(III) complexion. The dinitro-complex has been characterized and optically resolved using ammonium D-2- bromo-4,7-dimethyl-3-oxobicyclo[2

  外消旋的2,2'-联哌啶和内消旋形式的分离已通过二胺的二盐酸盐进行。外消旋2,2'-联哌啶与[Co（NO 2）6 ] 3–的反应已显示仅产生一对DL的反-双（2,2'-联哌啶）二硝基钴（III）络合物。已经使用D -2-溴-4,7-二甲基-3-氧代双环[2.2.1]庚烷-7-甲磺酸铵铵表征并光学拆分了二硝基配合物。光学纯的（–）589从不太溶解的非对映异构体中回收了-2,2'-联哌啶，其比旋度为–12.2°。关于应变能最小化计算的预测，讨论了反式-二硝基配合物的立体选择性形成。
• Process for the racemization of an alpha-amino acid
  申请人：BEECHAM GROUP PLC

  公开号：EP0173921A1

  公开（公告）日：1986-03-12

  Process for racemisation of amino acids by use of a ketone and an organic acid such as acetic acid. In particular, a process for resolution of free a-amino acdis with in situ racemisation. The resolution of 4 hydroxyphenylglycine and 3,4 dihydroxyphenylglycine with 3-bromocamphor-9-sulphonic acid with in situ racemisation are specifically mentioned.

  利用酮和有机酸（如乙酸）对氨基酸进行消旋化的工艺。特别是游离 a- 氨基酸原位消旋化的解析工艺。特别提到用 3-溴樟脑-9-磺酸原位消旋化 4-羟基苯甘氨酸和 3,4-二羟基苯甘氨酸。
• Precipitation-induced asymmetric transformation of chiral alpha-amino acids and salts thereof
  申请人：HOECHST CELANESE CORPORATION

  公开号：EP0499376A1

  公开（公告）日：1992-08-19

  The present invention provides a method for resolving a mixture of optically active isomers of an α-amino acid to obtain the preferred optically active isomer. The mixture of isomers is contacted with at least one chiral resolving agent in an organic acid, which is at least a partial solvent for the α-amino acid, and in the presence of a mineral acid, which is present in a quantity which does not protonate the NH₂ functionality of the α-amino acid to an extent that diastereomer interconversion is substantially prevented, and in the presence of a catalytic amount of an aromatic aldehyde. The contacting results in simultaneous resolution of a desired diastereomer and interconversion of the remaining undesired diastereomer, to provide a very high yield of the desired diastereomer having a very high optical purity.

  本发明提供了一种解析α-氨基酸光学活性异构体混合物以获得优选光学活性异构体的方法。异构体混合物在有机酸中与至少一种手性分解剂接触，有机酸至少是 α- 氨基酸的部分溶剂，同时存在一种矿物酸，矿物酸的存在量不会使 α- 氨基酸的 NH₂ 官能质子化到基本上阻止非对映异构体相互转化的程度，同时存在催化量的芳香醛。接触过程中，所需的非对映异构体和剩余的非所需非对映异构体的相互转化同时进行，从而获得收率极高、光学纯度极高的所需非对映异构体。