Chloro-acetic acid N'-(4-methyl-quinolin-2-yl)-hydrazide | 177612-01-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Chloro-acetic acid N'-(4-methyl-quinolin-2-yl)-hydrazide
• 英文别名: 2-chloro-N'-(4-methylquinolin-2-yl)acetohydrazide
• CAS: 177612-01-0
• 化学式: C₁₂H₁₂ClN₃O
• 分子量: 249.7
• InChiKey: JFBYMWHJXFNYIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  54
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  胡椒醛 、 Chloro-acetic acid N'-(4-methyl-quinolin-2-yl)-hydrazide 在 sodium methylate 作用下， 以78%的产率得到(2S,3R)-3-Benzo[1,3]dioxol-5-yl-oxirane-2-carboxylic acid N'-(4-methyl-quinolin-2-yl)-hydrazide
  参考文献：
  名称：

  Oxiranes with quinoline substitution : Stereoselective synthesis and antiviral activity

  摘要：

  A series of new quinoline substituted oxiranes were synthesised by the reaction of 2-N-(chloroacetyl)-1-(4'-methyl-2'-quinolinyl) hydrazide and aromatic aldehydes. These compounds were tested against encephalomyocarditis virus (EMCV) and only two compounds exhibited protection against the virus. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00125-4
• 作为产物：
  描述：

  4-甲基-2-氯-喹啉 在 一水合肼 作用下， 以 苯 为溶剂， 生成 Chloro-acetic acid N'-(4-methyl-quinolin-2-yl)-hydrazide
  参考文献：
  名称：

  Oxiranes with quinoline substitution : Stereoselective synthesis and antiviral activity

  摘要：

  A series of new quinoline substituted oxiranes were synthesised by the reaction of 2-N-(chloroacetyl)-1-(4'-methyl-2'-quinolinyl) hydrazide and aromatic aldehydes. These compounds were tested against encephalomyocarditis virus (EMCV) and only two compounds exhibited protection against the virus. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00125-4