methyl 2-(4-acetyl-2-methoxycarbonylmethoxyphenoxy)acetate | 166952-77-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 2-(4-acetyl-2-methoxycarbonylmethoxyphenoxy)acetate
• 英文别名: dimethyl 2,2'-([4-acetyl]phenylene-1,2-dioxy)diacetate；Methyl 2-[4-acetyl-2-(2-methoxy-2-oxoethoxy)phenoxy]acetate
• CAS: 166952-77-8
• 化学式: C₁₄H₁₆O₇
• 分子量: 296.277
• InChiKey: JBKFYPMDIMNEQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  88.1
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  methyl 2-(4-acetyl-2-methoxycarbonylmethoxyphenoxy)acetate 在 哌啶 、 lithium aluminium tetrahydride 、 Amberlist-15 、 potassium tert-butylate 作用下， 以 乙醇 、 水 为溶剂， 反应 8.0h， 生成 3-[3,4-bis-(2-hydroxy-ethoxy)-benzoyl]-chromen-2-one
  参考文献：
  名称：

  Novel polyaminocarboxylate chelates derived from 3-aroylcoumarins

  摘要：

  We have devised efficient reaction pathways to attach aminopolycarboxylate subunits to the 3-aroylcoumarin chromophore. Two series of compounds were thus prepared in which the chelating arms were directly bonded to the coumarin ring (series A) or to the 3-aroyl moiety (series B). The corresponding Eu(m) and Tb(III) chelates were easily formed and their photophysical properties measured. In all the cases, lanthanide emission lifetimes were in the range of ms. Unfortunately, quantum yields were relatively low. Measurement of T-1 states gave too low range of values to sensitize Tb(m). In fact, the metal emission of Tb(III) chelates of series A was not observed. However, series B was able to sensitize both metals. The absorption/energy-transfer/emission mechanisms are discussed. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00168-5
• 作为产物：
  描述：

  3,4-二羟基苯乙酮 、 溴乙酸甲酯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 生成 methyl 2-(4-acetyl-2-methoxycarbonylmethoxyphenoxy)acetate
  参考文献：
  名称：

  Heterocyclic derivatives

  摘要：

  公式I的化合物及其代谢易降解的酯和酰胺，以及其药学上可接受的盐，其中R.sup.13、M.sup.2、X.sup.1、Z.sup.1、Z.sup.1a、X.sup.2和A.sup.1的含义如规范中所述。这些化合物可用作抑制纤维蛋白原与糖蛋白IIb/IIIa结合的药物。还披露了新的中间体。

  公开号：

  US05652242A1

文献信息

• Heterocyclic derivatives
  申请人：Zeneca Limited

  公开号：US05556977A1

  公开（公告）日：1996-09-17

  Compounds of formula I ##STR1## and metabolically labile esters and amides thereof, and pharmaceutically acceptable salts thereof, in which R.sup.13, M.sup.2, X.sup.1, Z.sup.1, Z.sup.1a, X.sup.2 and A.sup.1 have the meanings given in the specification. The compounds are useful as inhibitors of the binding of fibrinogen to glycoprotein IIb/IIIa. Intermediates are also disclosed.

  公式I的化合物及其代谢易降解的酯和酰胺，以及其药学上可接受的盐，其中R.sup.13，M.sup.2，X.sup.1，Z.sup.1，Z.sup.1a，X.sup.2和A.sup.1具有规范中给定的含义。这些化合物可用作抑制纤维蛋白原与糖蛋白IIb/IIIa结合的抑制剂。还披露了中间体。
• Synthesis and In vitro Analysis of Novel Dihydroxyacetophenone Derivatives with Antimicrobial and Antitumor Activities
  作者：Ana Zbancioc、Anca Miron、Cristina Tuchilus、Pincu Rotinberg、Cosmin Mihai、Ionel Mangalagiu、Gheorghita Zbancioc

  DOI：10.2174/15734064113096660070

  日期：2014.5.31

  Herein we report a feasible study concerning the design, syntheses and in vitro antimicrobial and antitumoral activities of some novel compounds with dihydroxyacetophenone (DA) moiety. An efficient and general method for the preparation of diazine with dihydroxyacetophenone (DDA) skeleton under conventional thermal heating (TH), microwave (MW) and ultrasounds (US) irradiation is presented. Antimicrobial and antitumoral tests prove that some dihydroxyacetophenone compounds (the brominated derivatives BrDA 3) have a significant biological activity. It is also to be pointed out that, basically all the dihydroxyacetophenone derivatives proved to have a powerful antibacterial activity against drug resistant Gram-negative strain Pseudomonas aeruginosa ATCC 27853. Of particular interest could be the excellent antibacterial activity of our dihydroxyacetophenone compounds against drug resistant Gram-negative strain Pseudomonas aeruginosa.

  在此，我们报告了一项关于一些具有二羟基苯乙酮（DA）分子的新型化合物的设计、合成、体外抗菌和抗肿瘤活性的可行性研究。本文介绍了一种在传统热加热（TH）、微波（MW）和超声（US）辐照下制备具有二羟基苯乙酮（DDA）骨架的重氮的高效通用方法。抗菌和抗肿瘤试验证明，某些二羟基苯乙酮化合物（溴化衍生物 BrDA 3）具有显著的生物活性。还需要指出的是，基本上所有的二羟基苯乙酮衍生物都被证明对耐药性革兰氏阴性菌株铜绿假单胞菌 ATCC 27853 具有强大的抗菌活性。特别值得关注的是，我们的二羟基苯乙酮化合物对耐药革兰氏阴性假单胞菌具有极佳的抗菌活性。
• Heterocyclic derivatives as platelet aggregation inhibitors
  申请人：ZENECA LIMITED

  公开号：EP0825184A1

  公开（公告）日：1998-02-25

  RS 3-Methyl-4-[4-(4-pyridyl)piperazin-1-yl]phenoxybutyric acid and metabolically labile ester or amides thereof, and pharmaceutically acceptable salts thereof useful as an inhibitor of the binding of fibrinogen to glycoprotein IIb/IIIa.

  RS 3-甲基-4-[4-(4-吡啶基)哌嗪-1-基]苯氧基丁酸及其代谢易变酯或酰胺，以及可用作纤维蛋白原与糖蛋白 IIb/IIIa 结合抑制剂的药学上可接受的盐。
• Lal, Bansi; Gangopadhyay, Ashok K.; Jagtap, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2007, vol. 46, # 11, p. 1815 - 1832
  作者：Lal, Bansi、Gangopadhyay, Ashok K.、Jagtap、Tanpure, Rajendra、Rao、Gupte, Ravindra D.、Subbarayan、Asudani, Gope

  DOI：——

  日期：——
• Zbancioc, Gheorghita N.; Zbancioc, Ana Maria V.; Mantu, Dorina, Revue Roumaine de Chimie, 2010, vol. 55, # 11-12, p. 983 - 987
  作者：Zbancioc, Gheorghita N.、Zbancioc, Ana Maria V.、Mantu, Dorina、Miron, Anca、Tanase, Catalin、Mangalagiu, Ionel I.

  DOI：——

  日期：——