1-(3,4-bis(2-hydroxyethoxy)phenyl)ethanone | 113393-36-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(3,4-bis(2-hydroxyethoxy)phenyl)ethanone
• 英文别名: 1-[3,4-Bis(2-hydroxyethoxy)phenyl]ethan-1-one；1-[3,4-bis(2-hydroxyethoxy)phenyl]ethanone
• CAS: 113393-36-5
• 化学式: C₁₂H₁₆O₅
• 分子量: 240.256
• InChiKey: ZCGJAKDLYCIJND-UHFFFAOYSA-N

物化性质

• 沸点：
  440.0±35.0 °C(Predicted)
• 密度：
  1.219±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(3,4-bis(2-hydroxyethoxy)phenyl)ethanone 在 哌啶 、 potassium tert-butylate 作用下， 以 乙醇 为溶剂， 生成 3-[3,4-bis-(2-hydroxy-ethoxy)-benzoyl]-chromen-2-one
  参考文献：
  名称：

  含3-芳基香豆素的氨基多羧酸配体的（（III）和ter（III）配合物的合成和发光性能

  摘要：

  合成了三个不同取代的3-芳酰基香豆素L 1–3，它们具有锚定在3-苯甲酰基上的四酸螯合亚基，并且它们与Eu 3+和Tb 3+的配合物形成了新的潜在生物亲和力测定标记。报道了该配合物在水和甲醇中的某些光谱和发光性质。

  DOI：

  10.1016/s0040-4039(00)74433-9
• 作为产物：
  描述：

  3,4-二羟基苯乙酮 在 lithium aluminium tetrahydride 、 Amberlist-15 作用下， 以 水 为溶剂， 生成 1-(3,4-bis(2-hydroxyethoxy)phenyl)ethanone
  参考文献：
  名称：

  Novel polyaminocarboxylate chelates derived from 3-aroylcoumarins

  摘要：

  We have devised efficient reaction pathways to attach aminopolycarboxylate subunits to the 3-aroylcoumarin chromophore. Two series of compounds were thus prepared in which the chelating arms were directly bonded to the coumarin ring (series A) or to the 3-aroyl moiety (series B). The corresponding Eu(m) and Tb(III) chelates were easily formed and their photophysical properties measured. In all the cases, lanthanide emission lifetimes were in the range of ms. Unfortunately, quantum yields were relatively low. Measurement of T-1 states gave too low range of values to sensitize Tb(m). In fact, the metal emission of Tb(III) chelates of series A was not observed. However, series B was able to sensitize both metals. The absorption/energy-transfer/emission mechanisms are discussed. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00168-5

文献信息

• Synthesis and luminiscence properties of europium(III) and terbium(III) complexes of aminopolycarboxylic acid ligands containing 3-aroylcoumarin
  作者：Juan Carlos Rodríguez-Ubis、María Teresa Alonso、Ernesto Brunet

  DOI：10.1016/s0040-4039(00)74433-9

  日期：1994.11

  differently substituted 3-aroylcoumarins, L1–3, with tetraacid chelating subunits anchored at the 3-benzoyl group were synthesized, and their complexes with Eu3+ and Tb3+ formed as new potential bioaffinity-assay markers. Some spectral and luminescence properties of the complexes in water and methanol are reported.

  合成了三个不同取代的3-芳酰基香豆素L 1–3，它们具有锚定在3-苯甲酰基上的四酸螯合亚基，并且它们与Eu 3+和Tb 3+的配合物形成了新的潜在生物亲和力测定标记。报道了该配合物在水和甲醇中的某些光谱和发光性质。
• 一种（2-羟基乙氧基）喹啉-4-醇的制备方法
  申请人：湖南华腾制药有限公司

  公开号：CN106749006A

  公开（公告）日：2017-05-31

  本发明公开了一种(2‑羟基乙氧基)喹啉‑4‑醇的制备方法，以1‑(3,4‑双(2‑羟基乙氧基)苯基)乙酮为起始原料，经过硝化、还原、关环得到目标产物，该化合物是重要的医药中间体。
• Novel polyaminocarboxylate chelates derived from 3-aroylcoumarins
  作者：Ernesto Brunet、Marı́a Teresa Alonso、Olga Juanes、Oscar Velasco、Juan Carlos Rodrı́guez-Ubis

  DOI：10.1016/s0040-4020(01)00168-5

  日期：2001.4

  We have devised efficient reaction pathways to attach aminopolycarboxylate subunits to the 3-aroylcoumarin chromophore. Two series of compounds were thus prepared in which the chelating arms were directly bonded to the coumarin ring (series A) or to the 3-aroyl moiety (series B). The corresponding Eu(m) and Tb(III) chelates were easily formed and their photophysical properties measured. In all the cases, lanthanide emission lifetimes were in the range of ms. Unfortunately, quantum yields were relatively low. Measurement of T-1 states gave too low range of values to sensitize Tb(m). In fact, the metal emission of Tb(III) chelates of series A was not observed. However, series B was able to sensitize both metals. The absorption/energy-transfer/emission mechanisms are discussed. (C) 2001 Elsevier Science Ltd. All rights reserved.