7-hydroxy-6-[(4-methylpiperazin-1-yl)carbonyl]-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinolin-5-one | 423146-24-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-hydroxy-6-[(4-methylpiperazin-1-yl)carbonyl]-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinolin-5-one
• 英文别名: 4-hydroxy-3-(4-methylpiperazine-1-carbonyl)-1-azatricyclo[7.3.1.05,13]trideca-3,5,7,9(13)-tetraen-2-one
• CAS: 423146-24-1
• 化学式: C₁₈H₂₁N₃O₃
• 分子量: 327.383
• InChiKey: WGCZAWDEUNTOHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-hydroxy-6-[(4-methylpiperazin-1-yl)carbonyl]-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinolin-5-one 在 盐酸 作用下， 以 乙醇 为溶剂， 以80%的产率得到4-Hydroxy-3-(4-methylpiperazin-4-ium-1-carbonyl)-1-azatricyclo[7.3.1.05,13]trideca-3,5,7,9(13)-tetraen-2-one;chloride
  参考文献：
  名称：

  4-Hydroxy-2-quinolones 148. Synthesis and antitubercular activity of 1-hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid N-R-amides

  摘要：

  An improved method for the preparation of ethyl 1-hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylate has been proposed and a series of hetarylamides has been synthesized from it. A comparative analysis has been carried out of the antitubercular activities of the synthesized compounds with the active structural analogs 4-hydroxy-2-oxo-1,2-dihydroquinoline-3 and 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxamides studied before.

  DOI：

  10.1007/s10593-008-0139-9
• 作为产物：
  描述：

  N-甲基哌嗪 、 ethyl 7-hydroxy-5-oxo-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-6-carboxylate 以 N,N-二甲基甲酰胺 为溶剂， 生成 7-hydroxy-6-[(4-methylpiperazin-1-yl)carbonyl]-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinolin-5-one
  参考文献：
  名称：

  4-Hydroxy-2-quinolones 148. Synthesis and antitubercular activity of 1-hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid N-R-amides

  摘要：

  An improved method for the preparation of ethyl 1-hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylate has been proposed and a series of hetarylamides has been synthesized from it. A comparative analysis has been carried out of the antitubercular activities of the synthesized compounds with the active structural analogs 4-hydroxy-2-oxo-1,2-dihydroquinoline-3 and 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxamides studied before.

  DOI：

  10.1007/s10593-008-0139-9

文献信息

• 4-Hydroxy-2-quinolones 148. Synthesis and antitubercular activity of 1-hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid N-R-amides
  作者：I. V. Ukrainets、A. A. Tkach、L. A. Grinevich

  DOI：10.1007/s10593-008-0139-9

  日期：2008.8

  An improved method for the preparation of ethyl 1-hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylate has been proposed and a series of hetarylamides has been synthesized from it. A comparative analysis has been carried out of the antitubercular activities of the synthesized compounds with the active structural analogs 4-hydroxy-2-oxo-1,2-dihydroquinoline-3 and 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxamides studied before.