(3S,3aS,10aS,12aS,12bR)-3-hydroxy-3a-methyl-1,2,3,3a,4,9,10,11,12,12b-decahydro-10a,12a-epoxybenzo[4,5]cyclohepta[1,2-e]inden-7(8H)-one | 1041183-92-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3S,3aS,10aS,12aS,12bR)-3-hydroxy-3a-methyl-1,2,3,3a,4,9,10,11,12,12b-decahydro-10a,12a-epoxybenzo[4,5]cyclohepta[1,2-e]inden-7(8H)-one
• CAS: 1041183-92-9
• 化学式: C₁₉H₂₄O₃
• 分子量: 300.398
• InChiKey: VHUGHSQONPYIRM-HVMFNXBNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.07
• 重原子数：
  22.0
• 可旋转键数：
  0.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  46.53
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (3S,3aS,10aS,12aS,12bR)-3-hydroxy-3a-methyl-1,2,3,3a,4,9,10,11,12,12b-decahydro-10a,12a-epoxybenzo[4,5]cyclohepta[1,2-e]inden-7(8H)-one 、 4-溴苯甲酰氯 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 以86%的产率得到(3S,3aS,10aS,12aS,12bR)-3a-methyl-7-oxo-1,2,3,3a,4,7,8,9,10,11,12,12b-dodecahydro-10a,12a-epoxybenzo[4,5]cyclohepta[1,2-e]inden-3-yl 4-bromobenzoate
  参考文献：
  名称：

  Total Synthesis of Cortistatins A and J

  摘要：

  This paper describes the details of our synthetic studies on the marine steroidal alkaloids cortistatins A and J. The key features of our strategy include (i) an efficient Knoevenagel/electrocyclic strategy to couple the diketone and the CD-ring fragment, (ii) a chemoselective radical cyclization to construct the oxabicyclo[3.2.1]octene B-ring system, (iii) a highly stereocontrolled installation of the isoquinoline unit, and (iv) a late-stage functionalization of the A-ring.

  DOI：

  10.1021/jo2002616
• 作为产物：
  描述：

  (3S,3aS,10aS,12aS,12bR)-3-(tert-butyldimethylsiloxy)-3a-methyl-1,2,3,3a,4,9,10,11,12,12b-decahydro-10a,12a-epoxybenzo[4,5]cyclohepta[1,2-e]-inden-7(8H)-one 在 氟化氢吡啶 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以94%的产率得到(3S,3aS,10aS,12aS,12bR)-3-hydroxy-3a-methyl-1,2,3,3a,4,9,10,11,12,12b-decahydro-10a,12a-epoxybenzo[4,5]cyclohepta[1,2-e]inden-7(8H)-one
  参考文献：
  名称：

  Total Synthesis of Cortistatins A and J

  摘要：

  This paper describes the details of our synthetic studies on the marine steroidal alkaloids cortistatins A and J. The key features of our strategy include (i) an efficient Knoevenagel/electrocyclic strategy to couple the diketone and the CD-ring fragment, (ii) a chemoselective radical cyclization to construct the oxabicyclo[3.2.1]octene B-ring system, (iii) a highly stereocontrolled installation of the isoquinoline unit, and (iv) a late-stage functionalization of the A-ring.

  DOI：

  10.1021/jo2002616