<1-14C> isopentenyl pyrophosphate | 16541-17-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: <1-14C> isopentenyl pyrophosphate
• 英文别名: Isopentenyl-pyrophosphat-<1-C¹⁴>；[14C]-Isopentenyl pyrophosphate；[1-(14)C]-isopentenyl pyrophosphate；diphosphoric acid mono-(3-methyl-[1-¹⁴C]but-3-enyl) ester；3-methyl(114C)but-3-enyl phosphono hydrogen phosphate
• CAS: 16541-17-6
• 化学式: C₅H₁₂O₇P₂
• 分子量: 248.083
• InChiKey: NUHSROFQTUXZQQ-DOMIDYPGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  <1-14C> isopentenyl pyrophosphate 生成 椒二醇
  参考文献：
  名称：

  WHITEHEAD, IAN M.;THRELFALL, DAVID R.;EWING, DAVID F., PHYTOCHEMISTRY, 28,(1989) N 3, C. 775-779

  摘要：

  DOI：

文献信息

• Linear Free Energy Relationships Demonstrate a Catalytic Role for the Flavin Mononucleotide Coenzyme of the Type II Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase
  作者：Christopher J. Thibodeaux、Wei-chen Chang、Hung-wen Liu

  DOI：10.1021/ja104090m

  日期：2010.7.28

  The type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IDI-2) catalyzes the reversible isomerization of the two ubiquitous isoprene units, isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP), which are required to initiate the biosynthesis of all isoprenoid compounds found in nature. The overall chemical transformation catalyzed by IDI-2 involves a net 1,3-proton addition/elimination reaction. Surprisingly, IDI-2 requires a reduced flavin mononucleotide (FMN) coenzyme to carry out this redox neutral isomerization. The exact function of FMN in catalysis has not yet been clearly defined. To provide mechanistic insight into the role of the reduced flavin in IDI-2 catalysis, several FMN analogues with altered electronic properties were chemoenzymatically prepared, and their effects on the kinetic properties of the IDI-2 catalyzed reaction were investigated. Linear free energy relationships (LFERs) between the electronic properties of the flavin and the steady state kinetic parameters of the IDI-2 catalyzed reaction were observed. The LFER studies are complemented with kinetic isotope effect studies and kinetic characterization of an active site mutant enzyme (Q154N). Cumulatively, the data presented in this work (and in other studies) suggest that the reduced FMN coenzyme of IDI-2 functions as an acid/base catalyst, with the N5 atom of the flavin likely playing a critical role in the deprotonation of IPP en route to DMAPP formation. Several potential chemical mechanisms involving the reduced flavin as an acid/base catalyst are presented and discussed.
• Facile enzymatic synthesis of labelled geranyl pyrophosphate
  作者：Lutz Heide、Mamoru Tabata

  DOI：10.1016/s0040-4039(01)80621-3

  日期：1989.1
• HEIDE, LUTZ;TABATA, MAMORU, TETRAHEDRON LETT., 30,(1989) N, C. 813-814
  作者：HEIDE, LUTZ、TABATA, MAMORU

  DOI：——

  日期：——
• WHITEHEAD, IAN M.;THRELFALL, DAVID R.;EWING, DAVID F., PHYTOCHEMISTRY, 28,(1989) N 3, C. 775-779
  作者：WHITEHEAD, IAN M.、THRELFALL, DAVID R.、EWING, DAVID F.

  DOI：——

  日期：——