hexyn-1-ol | 181878-30-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: hexyn-1-ol
• 英文别名: Hexynol；hex-1-yn-1-ol
• CAS: 181878-30-8
• 化学式: C₆H₁₀O
• 分子量: 98.1448
• InChiKey: MLRKYSNODSLPAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  hexyn-1-ol 在 2,6-二甲基吡啶 、 三氟甲磺酸酐 作用下， 以 二氯甲烷 为溶剂， 反应 2.5h， 生成 N-[(R,R)-2-(hex-5-ynylamino)-1,2-diphenylethyl]-4-methyl benzenesulfonamide
  参考文献：
  名称：

  Use of triazole-ring formation to attach a Ru/TsDPEN complex for asymmetric transfer hydrogenation to a soluble polymer

  摘要：

  The cycloaddition of a chiral ligand containing a terminal alkyne to a soluble polymer containing an azide provides a convenient means for the attachment of an asymmetric transfer hydrogenation catalyst to a soluble polymer support. Using these ligands in complexes with Ru(II), gave good results in terms of conversion and enantioselectivity (up to 95% ee) in ketone reduction reactions. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2013.05.022

文献信息

• Enantioselective Synthesis of 5,7-Bicyclic Ring Systems from Axially Chiral Allenes Using a Rh(I)-Catalyzed Cyclocarbonylation Reaction
  作者：Francois Grillet、Kay M. Brummond

  DOI：10.1021/jo4002432

  日期：2013.4.19

  pattern of the allene affected the transfer of chiral information. Complete transfer of chirality was obtained for all trisubstituted allenes, but loss of chiral information was observed for disubstituted allenes. This work constitutes the first demonstration of a transfer of chiral information from an allene to the 5-position of a cyclopentenone using a cyclocarbonylation reaction. The absolute configuration

  描述了分子内 Rh(I) 催化的联烯 Pauson–Khand 反应 (APKR) 中的手性转移，以​​对映选择性地获得四氢甘菊酮、四氢环戊[ c ]氮杂酮和二氢环戊[ c ]氧杂环庚酮 (22-99% ee)。丙二烯的取代模式影响手性信息的传递。所有三取代丙二烯均获得了手性的完全转移，但二取代丙二烯观察到手性信息丢失。这项工作首次证明了利用环羰基化反应将手性信息从丙二烯转移到环戊烯酮的 5 位。相应的环羰基化产物的绝对构型也被确定，这是很少有人做到的。
• Acetylenic sulfonamide derivatives
  申请人：——

  公开号：US20040198833A1

  公开（公告）日：2004-10-07

  The present invention provides compounds of formula (I), useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.

  本发明提供了化合物(I)的公式，用于增强哺乳动物中谷氨酸受体的功能，因此，用于治疗各种疾病，如精神病和神经系统疾病。
• Enhanced mechano-responsive fluorescence in polydiacetylene thin films through functionalization with tetrazine dyes: photopolymerization, energy transfer and AFM coupled to fluorescence microscopy studies
  作者：Luca Polacchi、Arnaud Brosseau、Régis Guillot、Rémi Métivier、Clémence Allain

  DOI：10.1039/d1cp03458h

  日期：——

  development of mechano-responsive fluorescent materials is essential for the design and construction of reliable and versatile sensors for mechanical stress. Herein, novel energy transfer-based systems with tetrazine fluorophore and a polydiacetylene (PDA) backbone are synthesized and studied comparatively to a simple polydiacetylene in the form of thin films. Their photopolymerization properties, energy

  机械响应荧光材料的开发对于设计和构建可靠且通用的机械应力传感器至关重要。在此，合成并研究了具有四嗪荧光团和聚二乙炔 (PDA) 主链的新型能量转移系统，并与薄膜形式的简单聚二乙炔进行了比较。评估了它们的光聚合特性、能量转移效率和对纳米级机械刺激的荧光响应。指出 PDA 链上的自组装基团影响链的几何排列和薄膜形态，从而影响聚合效率和动力学以及能量转移效率。而且，
• Process for the preparation of 3,5-disubstituted isoxazoles
  申请人：Zambon S.p.A.

  公开号：US04772719A1

  公开（公告）日：1988-09-20

  A novel process for the preparation of 3-bromo- and 3-chloro-5-substituted isoxazoles is provided. Dibromo- or dichloro-formaldoxime is reacted with an excess of an 1-alkyne derivative of the formula R--C.tbd.CH where R is hydrogen, phenyl or 1-6 C alkyl optionally substituted by halogen, OH, OR', CHO, COR', COOR', CONH.sub.2, CONR'R" or NHCOR' where, in turn, R' and R", which may be the same or different, are a 1-6 C alkyl or haloalkyl, in the presence of (i) at least an equimolecular amount, with respect to the dibromo- or dichloro-formaldoxime, of an alkaline base selected from the class consisting of sodium and potassium carbonate and bicarbonate and (ii) an inert solvent in which the 1-alkyne is soluble at room temperature.

  提供了一种制备3-溴和3-氯-5-取代异噁唑的新工艺。在碱性催化剂的存在下，将二溴或二氯甲醛肟与公式为R-C.tbd.CH的1-炔基衍生物的过量反应，其中R是氢、苯基或1-6个碳原子的烷基，可选地被卤素、OH、OR'、CHO、COR'、COOR'、CONH.sub.2、CONR'R"或NHCOR'取代，其中R'和R"可以相同或不同，是1-6个碳原子的烷基或卤代烷基，且存在惰性溶剂，其中1-炔基在室温下溶解。碱性催化剂可以选择从钠和钾碳酸盐和碳酸氢盐中选择至少一个等摩尔量。
• STACKING NUCLEIC ACID AND METHODS FOR USE THEREOF
  申请人：Schneider Uffe Vest

  公开号：US20140065676A1

  公开（公告）日：2014-03-06

  The present invention provides a novel modified oligonucleotide monomer useful in molecular biological techniques such as capture and/or detection of nucleic acids, amplification of nucleic acids and sequencing of nucleic acids. The modified oligonucleotide monomer comprises an intercalator that can intercalate into an antiparallel duplex from the major groove.

  本发明提供了一种新型的修饰寡核苷酸单体，在分子生物学技术中具有捕获和/或检测核酸、核酸扩增和核酸测序等方面的应用。该修饰寡核苷酸单体包括一种可以插入到反平行双链的主沟槽中的插入剂。