N-[(R,R)-2-(hex-5-ynylamino)-1,2-diphenylethyl]-4-methyl benzenesulfonamide | 1448552-43-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: N-[(R,R)-2-(hex-5-ynylamino)-1,2-diphenylethyl]-4-methyl benzenesulfonamide
• 英文别名: N-[(1R,2R)-2-(hex-5-ynylamino)-1,2-diphenylethyl]-4-methylbenzenesulfonamide
• CAS: 1448552-43-9
• 化学式: C₂₇H₃₀N₂O₂S
• 分子量: 446.613
• InChiKey: NYSDTLCNKKYXMJ-KAYWLYCHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  32
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  66.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-[(R,R)-2-(hex-5-ynylamino)-1,2-diphenylethyl]-4-methyl benzenesulfonamide 、 苄基叠氮 在 copper(ll) sulfate pentahydrate 、 sodium ascorbate 作用下， 以 水 、 叔丁醇 为溶剂， 反应 3.0h， 以66.6%的产率得到
  参考文献：
  名称：

  Use of triazole-ring formation to attach a Ru/TsDPEN complex for asymmetric transfer hydrogenation to a soluble polymer

  摘要：

  The cycloaddition of a chiral ligand containing a terminal alkyne to a soluble polymer containing an azide provides a convenient means for the attachment of an asymmetric transfer hydrogenation catalyst to a soluble polymer support. Using these ligands in complexes with Ru(II), gave good results in terms of conversion and enantioselectivity (up to 95% ee) in ketone reduction reactions. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2013.05.022
• 作为产物：
  描述：

  hexyn-1-ol 在 2,6-二甲基吡啶 、 三氟甲磺酸酐 作用下， 以 二氯甲烷 为溶剂， 反应 2.5h， 生成 N-[(R,R)-2-(hex-5-ynylamino)-1,2-diphenylethyl]-4-methyl benzenesulfonamide
  参考文献：
  名称：

  Use of triazole-ring formation to attach a Ru/TsDPEN complex for asymmetric transfer hydrogenation to a soluble polymer

  摘要：

  The cycloaddition of a chiral ligand containing a terminal alkyne to a soluble polymer containing an azide provides a convenient means for the attachment of an asymmetric transfer hydrogenation catalyst to a soluble polymer support. Using these ligands in complexes with Ru(II), gave good results in terms of conversion and enantioselectivity (up to 95% ee) in ketone reduction reactions. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2013.05.022

文献信息

• Use of triazole-ring formation to attach a Ru/TsDPEN complex for asymmetric transfer hydrogenation to a soluble polymer
  作者：Charlotte M. Zammit、Martin Wills

  DOI：10.1016/j.tetasy.2013.05.022

  日期：2013.7

  The cycloaddition of a chiral ligand containing a terminal alkyne to a soluble polymer containing an azide provides a convenient means for the attachment of an asymmetric transfer hydrogenation catalyst to a soluble polymer support. Using these ligands in complexes with Ru(II), gave good results in terms of conversion and enantioselectivity (up to 95% ee) in ketone reduction reactions. (C) 2013 Elsevier Ltd. All rights reserved.