N⁴-phenyl-quinoline-3,4-diyldiamine | 99010-17-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N⁴-phenyl-quinoline-3,4-diyldiamine
• 英文别名: N⁴-Phenyl-chinolin-3,4-diyldiamin；4-N-phenylquinoline-3,4-diamine
• CAS: 99010-17-0
• 化学式: C₁₅H₁₃N₃
• 分子量: 235.288
• InChiKey: BHDABMVROBVQFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.9
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N⁴-phenyl-quinoline-3,4-diyldiamine 在 过氧乙酸 作用下， 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and Structure−Activity-Relationships of 1H-Imidazo[4,5-c]quinolines That Induce Interferon Production

  摘要：

  1H-Imidazo-[4,5-c]quinolines were prepared while investigating novel nucleoside analogues as potential antiviral agents. While these compounds showed no direct antiviral activity when tested in a number of cell culture systems, some demonstrated potent inhibition of virus lesion development in an intravaginal guinea pig herpes simplex virus-2 assay. We have determined that the in vivo antiviral activity can be attributed to the ability of these molecules to induce the production of cytokines, especially interferon (IFN), in this model. Subsequently, we found that the compounds also induce in vitro production of IFN in human peripheral blood mononuclear cells (hPBMCs). The in vitro results reported herein and the in vivo results reported previously led to the discovery of imiquimod, 26, which was developed as a topical agent and has been approved for the treatment of genital warts, actinic keratosis, and superficial basal cell carcinoma.

  DOI：

  10.1021/jm049211v
• 作为产物：
  描述：

  3-nitro-N-phenylquinolin-4-amine 在 乙醇 、 铁粉 、 溶剂黄146 作用下， 生成 N⁴-phenyl-quinoline-3,4-diyldiamine
  参考文献：
  名称：

  The Synthesis of Some 3-Nitro- and 3-Amino-4-dialkylaminoalkylaminoquinoline Derivatives

  摘要：

  DOI：

  10.1021/ja01150a002

文献信息

• Quinoline derivatives and preparation thereof
  申请人：COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

  公开号：US10227355B2

  公开（公告）日：2019-03-12

  The patent discloses novel quinoline derivatives of formula (I), (Formula should be inserted here) and process for preparing the same. The compounds of formula (I) can be further used for the synthesis of Inhibitors like Kinase Tyrosine Inhibitors.

  该专利公开了式 (I) 的新型喹啉衍生物（此处应插入式）及其制备方法。式 (I) 化合物可进一步用于合成激酶酪氨酸抑制剂等抑制剂。
• The Synthesis of Some 3-Nitro- and 3-Amino-4-dialkylaminoalkylaminoquinoline Derivatives
  作者：Alexander R. Surrey、Royal A. Cutler

  DOI：10.1021/ja01150a002

  日期：1951.6
• Methods Of Preventing Or Reducing A Fibrotic Response Using CSF1R Inhibitors
  申请人：Massachusetts Institute of Technology

  公开号：US20190083495A1

  公开（公告）日：2019-03-21

  Described herein are methods of preventing or reducing fibrosis comprising administering CSF1R inhibitors, coating formulations comprising CSF1R inhibitors, coatings comprising CSF1R inhibitors for implantable medical devices, CSF1R inhibitor coated implantable medical devices, as well as corresponding embodiments comprising additional agents.
• US4689338A
  申请人：——

  公开号：US4689338A

  公开（公告）日：1987-08-25
• US4698348A
  申请人：——

  公开号：US4698348A

  公开（公告）日：1987-10-06