1,2-bis(4-benzoylvinylphenoxy)ethane | 252006-60-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1,2-bis(4-benzoylvinylphenoxy)ethane
• 英文别名: (2E,2E)-3,3-(4,4-(ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(1-phenylprop-2-en-1-one)；(E)-3-[4-[2-[4-[(E)-3-oxo-3-phenyl-prop-1-enyl]phenoxy]ethoxy]phenyl]-1-phenyl-prop-2-en-1-one；(E)-3-[4-[2-[4-[(E)-3-oxo-3-phenylprop-1-enyl]phenoxy]ethoxy]phenyl]-1-phenylprop-2-en-1-one
• CAS: 252006-60-3
• 化学式: C₃₂H₂₆O₄
• 分子量: 474.556
• InChiKey: ZCEQMZFUQQNAFJ-YHARCJFQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  36
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  溶剂黄146 、 1,2-bis(4-benzoylvinylphenoxy)ethane 在 一水合肼 作用下， 以65%的产率得到1,2-bis[4-(1-acetyl-4,5-dihydro-3-phenyl-1H-pyrazol-5-yl)phenoxy]ethane
  参考文献：
  名称：

  Elwahy, Ahmed H. M., Journal of Chemical Research, Miniprint, 1999, # 10, p. 2582 - 2596

  摘要：

  DOI：
• 作为产物：
  描述：

  对羟基苯甲醛 在 potassium hydroxide 、 sodium hydroxide 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 生成 1,2-bis(4-benzoylvinylphenoxy)ethane
  参考文献：
  名称：

  围绕脂肪族链构建的新型双吡唑啉衍生物：合成，表征和抗菌研究

  摘要：

  双吡唑啉3a - 3h围绕不同长度的烷基链构建，是由比沙可康烯与苯基肼的环化反应合成的。从苯乙酮与各种双醛1a - 1h的Claisen-Schmidt反应中获得了Bischalcones 2a - 2h。通过IR，1 H-NMR，13 C-NMR，质量（ESI）和元素分析来表征中间的双缩水锥和最终的双杂环化合物。还评估了合成化合物的抗细菌和抗真菌活性，对肺炎克氏杆菌，铜绿假单胞菌，大肠埃希菌，金黄色葡萄球菌，枯草芽孢杆菌和janjan曲霉，黑曲霉和延寿草。发现双吡唑啉3a – 3h的抗菌性能取决于内部间隔单元的长度。 已经描述了围绕脂族链构建的双吡唑啉的合成和抗菌性能。发现这些双杂环化合物的抗微生物行为取决于内部间隔单元的长度。

  DOI：

  10.1007/s12039-012-0355-9

文献信息

• Novel bis(1-acyl-2-pyrazolines) of potential anti-inflammatory and molluscicidal properties
  作者：Flora F. Barsoum、Hanaa M. Hosni、Adel S. Girgis

  DOI：10.1016/j.bmc.2006.01.042

  日期：2006.6

  A variety of bis[3-aryl-4,5-dihydro-1H-pyrazol-1-carboxaldehydes] 4a-h were obtained via reaction of bis[1-aryl-2-propen-1-ones] 3a-h with hydrazine hydrate in refluxing formic acid. In addition, the corresponding bis[1-acetyl-3-aryl-4,5-dihydrol H-pyrazoles] 4i-m were formed through conducting the reaction of 3 with hydrazine hydrate in refluxing acetic acid. The starting bis(2-propen-1-ones) 3a-h were prepared stereoselectively as E,E'-geometric isomer via condensation of bisbenzaldehydes 1a,b with (un)substituted acetophetiones 2 in ethatiolic KOH solution. Anti-inflammatory as well as ulcerogenic activities of the prepared pyrazolines were evaluated in vivo and compared with that of a standard drug (indomethacin). Many of the tested compounds show remarkable anti-inflammatory properties with an ulcerogenic liability (especially 4f, g, j, and k) lower than that of the standard used drug. Compound 417 was established to be the best effectively prepared anti-inflammatory active pyrazoline derivative and safer than indomethacin with respect to its ulcerogenic liability. Molluscicidal activity of the prepared compounds against Biomphalaria alexandrina snails (the intermediate host of Schistosoma mansoni) was screened. Where, some of the prepared compounds show considerable activities. (c) 2006 Elsevier Ltd. All rights reserved.
• New bispyrazoline derivatives built around aliphatic chains: Synthesis, characterization and antimicrobial studies
  作者：MOHAMAD YUSUF、PAYAL JAIN

  DOI：10.1007/s12039-012-0355-9

  日期：2013.1

  Aspergillius janus, Aspergillus niger and Pencillium glabrum, respectively. The antimicrobial behaviour of the bispyrazolines 3a–3h is found to be dependent on the length of internal spacer unit. Synthesis and antimicrobial behaviour of the bispyrazolines built around the aliphatic chains have been described. The antimicrobial behaviour of these bisheterocyclic compounds is found to be dependent on the

  双吡唑啉3a - 3h围绕不同长度的烷基链构建，是由比沙可康烯与苯基肼的环化反应合成的。从苯乙酮与各种双醛1a - 1h的Claisen-Schmidt反应中获得了Bischalcones 2a - 2h。通过IR，1 H-NMR，13 C-NMR，质量（ESI）和元素分析来表征中间的双缩水锥和最终的双杂环化合物。还评估了合成化合物的抗细菌和抗真菌活性，对肺炎克氏杆菌，铜绿假单胞菌，大肠埃希菌，金黄色葡萄球菌，枯草芽孢杆菌和janjan曲霉，黑曲霉和延寿草。发现双吡唑啉3a – 3h的抗菌性能取决于内部间隔单元的长度。 已经描述了围绕脂族链构建的双吡唑啉的合成和抗菌性能。发现这些双杂环化合物的抗微生物行为取决于内部间隔单元的长度。
• Elwahy, Ahmed H. M., Journal of Chemical Research, Miniprint, 1999, # 10, p. 2582 - 2596
  作者：Elwahy, Ahmed H. M.

  DOI：——

  日期：——