(+/-) cis-Grandmarin

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: (+/-) cis-Grandmarin
• 英文别名: (9S,10S)-9,10-dihydroxy-5-methoxy-8,8-dimethyl-9,10-dihydropyrano[2,3-f]chromen-2-one
• 化学式: C₁₅H₁₆O₆
• 分子量: 292.288
• InChiKey: RRUHFAXVNXSPNG-JSGCOSHPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  85.2
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 (+/-) cis-Grandmarin 在 吡啶 作用下， 以92%的产率得到(+/-)-cis-3',4'-diacetoxy-3',4'-dihydro-5-methoxyseselin
  参考文献：
  名称：

  Natural and Synthetic 2,2-Dimethylpyranocoumarins with Antibacterial Activity

  摘要：

  A new efficient synthetic approach to the natural coumarins 5-hydroxyseselin (5), 5-methoxyseselin (3), and (+/-) cis-grandmarin (9) is described as well as the synthesis of some new derivatives in the 5-methoxyseselin series (10-15). The natural coumarins 7-hydroxyalloxanthyletin (6), alloxanthoxyletin (8), and dipetalolactone (7) have also been obtained as secondary products. The type of fusion of the pyrano ring in all cases has been established by 2D NMR spectroscopy. The compounds have been studied for their in vitro antibacterial activity, which has been compared with that of some previously synthesized seselin derivatives. The most active compounds were 3, 7, 8, 11, and 14. Some structure-activity relationships are discussed.

  DOI：

  10.1021/np0497447
• 作为产物：
  描述：

  间苯三酚甲醛 在 吡啶 、 甲醇 、 (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan) 、 potassium dioxotetrahydroxoosmate(VI) 、 甲基磺酰胺 、 potassium carbonate 、 三乙胺 、 N,N-二乙基苯胺 、 potassium iodide 、 potassium hexacyanoferrate(III) 作用下， 以 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 、 xylene 、 叔丁醇 为溶剂， 反应 8.17h， 生成 (+/-) cis-Grandmarin
  参考文献：
  名称：

  抗艾滋病剂。37.（3′R，4′R）-（+）-顺式-甲壳酮衍生物作为新型有效的抗HIV剂的合成和构效关系。

  摘要：

  为了探索作为新型抗HIV药物的（+）-顺式-khellactone衍生物的结构要求，使用24个单取代的3'，4'-di-O-（S）-樟脑酰基-（+）-顺式-khellactone（DCK）衍生物不对称合成。这些化合物包括4个异构的单甲氧基类似物（3-6），4个异构的单甲基类似物（7-10），4个4-烷基/芳基取代的类似物（11-14）和12个4-甲基-（+）-顺式具有3'，4'取代基的khellactone衍生物（15-26）。这些（+）-顺式-khellactone衍生物被筛选针对急性感染的H9淋巴细胞中的HIV-1复制。结果表明，（3'R，4'R）-（+）-顺式-khellactone骨架，3'-和4'-位置的两个（S）-（-）-樟脑酰基和甲基除6-位以外，香豆素环上的α是抗HIV活性的最佳结构部分。3-甲基-（7），4-甲基-（8）和5-甲基-（9）3'，4'-二-O-（S）-樟脑酰基-（3'R，4'R）-

  DOI：

  10.1021/jm9900624

文献信息

• New coumarins from some Citrus plants.
  作者：CHIHIRO ITO、MIYUKI MATSUOKA、TOYOKO MIZUNO、KAKO SATO、YOKO KIMURA、MOTOHARU JU-ICHI、MAMI INOUE、ICHIRO KAJIURA、MITSUO OMURA、HIROSHI FURUKAWA

  DOI：10.1248/cpb.36.3805

  日期：——

  Six new coumarins, 6-formylumbelliferone (1), hassanon (2), 5-hydroxyseselin (4), cis-grandmarin (6, cis), trans-grandmarin isovalerate (8, trans), and kinocoumarin (9), were isolated from roots and root barks of some Citrus plants, and their structures were determined by means of spectral and chemical studies.

  从一些柑橘植物的根和根皮中分离出六种新的香豆素，即6-甲酰伞形酮（1）、哈萨苷（2）、5-羟基芹菜素（4）、顺式大黄素（6，顺式）、反式大黄素异戊酸酯（8，反式）和木犀草素（9），并通过光谱和化学研究确定了它们的结构。
• Anti-AIDS agents-XXVIII.1 Synthesis and Anti-HIV activity of methoxy substituted 3′,4′-Di-O-(−)-camphanoyl-(+)-cis-khellactone (DCK) analogues
  作者：Yasuo Takeuchi、Lan Xie、L.Mark Cosentino、Kuo-Hsiung Lee

  DOI：10.1016/s0960-894x(97)10050-6

  日期：1997.10

  Four isomeric methoxy substituted DCK analogues (3-6) were asymmetrically synthesized from different starting materials. 5-Methoxy-3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (5) exhibited extremely potent anti-HIV activity against HIV-1 replication in H9 lymphocyte cells with EC50 and therapeutic index values of 0.00038 mu M and >402,632, respectively, which are better than those of DCK and AZT in this assay. (C) 1997 Elsevier Science Ltd.
• Anti-AIDS Agents. 37. Synthesis and Structure−Activity Relationships of (3‘<i>R</i>,4‘<i>R</i>)-(+)-<i>cis</i>-Khellactone Derivatives as Novel Potent Anti-HIV Agents
  作者：Lan Xie、Yasuo Takeuchi、L. Mark Cosentino、Kuo-Hsiung Lee

  DOI：10.1021/jm9900624

  日期：1999.7.1

  (+)-cis-khellactone derivatives as novel anti-HIV agents, 24 monosubstituted 3', 4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) derivatives were synthesized asymmetrically. These compounds included 4 isomeric monomethoxy analogues (3-6), 4 isomeric monomethyl analogues (7-10), 4 4-alkyl/aryl-substituted analogues (11-14), and 12 4-methyl-(+)-cis-khellactone derivatives (15-26) with varying 3', 4'-substituents

  为了探索作为新型抗HIV药物的（+）-顺式-khellactone衍生物的结构要求，使用24个单取代的3'，4'-di-O-（S）-樟脑酰基-（+）-顺式-khellactone（DCK）衍生物不对称合成。这些化合物包括4个异构的单甲氧基类似物（3-6），4个异构的单甲基类似物（7-10），4个4-烷基/芳基取代的类似物（11-14）和12个4-甲基-（+）-顺式具有3'，4'取代基的khellactone衍生物（15-26）。这些（+）-顺式-khellactone衍生物被筛选针对急性感染的H9淋巴细胞中的HIV-1复制。结果表明，（3'R，4'R）-（+）-顺式-khellactone骨架，3'-和4'-位置的两个（S）-（-）-樟脑酰基和甲基除6-位以外，香豆素环上的α是抗HIV活性的最佳结构部分。3-甲基-（7），4-甲基-（8）和5-甲基-（9）3'，4'-二-O-（S）-樟脑酰基-（3'R，4'R）-
• Natural and Synthetic 2,2-Dimethylpyranocoumarins with Antibacterial Activity
  作者：Eleni Melliou、Prokopios Magiatis、Sofia Mitaku、Alexios-Leandros Skaltsounis、Efrosini Chinou、Ioanna Chinou

  DOI：10.1021/np0497447

  日期：2005.1.1

  A new efficient synthetic approach to the natural coumarins 5-hydroxyseselin (5), 5-methoxyseselin (3), and (+/-) cis-grandmarin (9) is described as well as the synthesis of some new derivatives in the 5-methoxyseselin series (10-15). The natural coumarins 7-hydroxyalloxanthyletin (6), alloxanthoxyletin (8), and dipetalolactone (7) have also been obtained as secondary products. The type of fusion of the pyrano ring in all cases has been established by 2D NMR spectroscopy. The compounds have been studied for their in vitro antibacterial activity, which has been compared with that of some previously synthesized seselin derivatives. The most active compounds were 3, 7, 8, 11, and 14. Some structure-activity relationships are discussed.