N-methyl-N-(8-quinolinyl)-2-iodobenzamide | 1234561-38-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-methyl-N-(8-quinolinyl)-2-iodobenzamide
• 英文别名: 2-iodo-N-methyl-N-quinolin-8-ylbenzamide
• CAS: 1234561-38-6
• 化学式: C₁₇H₁₃IN₂O
• 分子量: 388.208
• InChiKey: XMQUQAAZXOPXKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-methyl-N-(8-quinolinyl)-2-iodobenzamide 在 palladium diacetate 、 三苯基膦 、 silver carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以74%的产率得到5-methyl-5H-benzo[c][1,10]phenanthrolin-6-one
  参考文献：
  名称：

  Design and preparation of aza-analogues of benzo[c]phenanthridine framework with cytotoxic and antiplasmodial activities

  摘要：

  Benzo[c]phenanthridine alkaloids represent interesting lead for the discovery of new potential antiplasmodial and/or anticancer drugs. In this field, a novel library of aza-analogs of benzo[c]phenanthroline framework derivatives was designed and prepared. Although these compounds did not have specific antiplasmodial activities, some of them displayed specific in vitro activity against two cancer lines especially compound 24 with an IC(50) against the MCF7 line of 0.6 mu M. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.03.006
• 作为产物：
  描述：

  2-iodo-N-(quinolin-8-yl)benzamide 、 碘甲烷 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 以74%的产率得到N-methyl-N-(8-quinolinyl)-2-iodobenzamide
  参考文献：
  名称：

  Design and preparation of aza-analogues of benzo[c]phenanthridine framework with cytotoxic and antiplasmodial activities

  摘要：

  Benzo[c]phenanthridine alkaloids represent interesting lead for the discovery of new potential antiplasmodial and/or anticancer drugs. In this field, a novel library of aza-analogs of benzo[c]phenanthroline framework derivatives was designed and prepared. Although these compounds did not have specific antiplasmodial activities, some of them displayed specific in vitro activity against two cancer lines especially compound 24 with an IC(50) against the MCF7 line of 0.6 mu M. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.03.006

文献信息

• Design and preparation of aza-analogues of benzo[c]phenanthridine framework with cytotoxic and antiplasmodial activities
  作者：Ange-Désiré Yapi、Nicolas Desbois、Jean-Michel Chezal、Olivier Chavignon、Jean-Claude Teulade、Alexis Valentin、Yves Blache

  DOI：10.1016/j.ejmech.2010.03.006

  日期：2010.7

  Benzo[c]phenanthridine alkaloids represent interesting lead for the discovery of new potential antiplasmodial and/or anticancer drugs. In this field, a novel library of aza-analogs of benzo[c]phenanthroline framework derivatives was designed and prepared. Although these compounds did not have specific antiplasmodial activities, some of them displayed specific in vitro activity against two cancer lines especially compound 24 with an IC(50) against the MCF7 line of 0.6 mu M. (C) 2010 Elsevier Masson SAS. All rights reserved.