(2R,4R)-2,4-dimethyl-5-oxotetrahydrofuran-2-carboxylic acid | 950489-52-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: (2R,4R)-2,4-dimethyl-5-oxotetrahydrofuran-2-carboxylic acid
• 英文别名: (2R,4R)-2,4-dimethyl-5-oxooxolane-2-carboxylic acid
• CAS: 950489-52-8
• 化学式: C₇H₁₀O₄
• 分子量: 158.154
• InChiKey: NWZNGXRJSXHFFN-CLZZGJSISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.41
• 重原子数：
  11.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  63.6
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (2R,4R)-2,4-dimethyl-5-oxotetrahydrofuran-2-carboxylic acid 在 硼烷 、 戴斯-马丁氧化剂 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 17.0h， 生成 (2R,4R)-2,4-dimethyl-5-oxotetrahydrofuran-2-carbaldehyde
  参考文献：
  名称：

  Preparation of enantiopure 3,5,5-trialkyl-γ-butyrolactones by diastereospecific 5-endo halo lactonizations

  摘要：

  A new preparation of 3,5,5-trialkyl-gamma-butyrolactones of defined absolute configuration is reported. This method involves the diastereoselective alkylation of 3,4-ethylenic acids after incorporation of a chiral Evans auxiliary, and then after separation of the two diastereomers and hydrolysis of the auxiliary, stereospecific halo lactonizations. This method was applied to the preparation of a natural product, present in a sponge. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2007.05.028
• 作为产物：
  描述：

  (R,E)-2-methyl-4-phenylpent-3-enoic acid 在 ruthenium trichloride sodium periodate 、 偶氮二异丁腈 、 三正丁基氢锡 作用下， 以 四氯化碳 、 二氯甲烷 、 水 、 乙腈 、 苯 为溶剂， 反应 18.0h， 生成 (2R,4R)-2,4-dimethyl-5-oxotetrahydrofuran-2-carboxylic acid
  参考文献：
  名称：

  Preparation of enantiopure 3,5,5-trialkyl-γ-butyrolactones by diastereospecific 5-endo halo lactonizations

  摘要：

  A new preparation of 3,5,5-trialkyl-gamma-butyrolactones of defined absolute configuration is reported. This method involves the diastereoselective alkylation of 3,4-ethylenic acids after incorporation of a chiral Evans auxiliary, and then after separation of the two diastereomers and hydrolysis of the auxiliary, stereospecific halo lactonizations. This method was applied to the preparation of a natural product, present in a sponge. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2007.05.028