4-甲基-6-硝基-2-哌啶-1-基喹啉 | 7461-64-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 4-甲基-6-硝基-2-哌啶-1-基喹啉
• 英文名称: 4-methyl-6-nitro-2-piperidino-quinoline
• 英文别名: 4-Methyl-6-nitro-2-piperidino-chinolin；4-Methyl-6-nitro-2-piperidin-1-ylquinoline
• CAS: 7461-64-5
• 化学式: C₁₅H₁₇N₃O₂
• 分子量: 271.319
• InChiKey: KEWUMZWYOOCFPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  62
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-甲基-6-硝基-2-哌啶-1-基喹啉 在 palladium 10% on activated carbon 、 氢气 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 生成 4-Methyl-2-piperidin-1-ylquinolin-6-amine
  参考文献：
  名称：

  Identification and optimization of novel 6-acylamino-2-aminoquinolines as potent Hsp90 C-terminal inhibitors

  摘要：

  In order to discover novel Hsp90 inhibitors targeting the C-terminal ATP binding pocket, a novobiocin derivative based ROCS model was constructed for virtual screening. Compound 13 was identified as the lead compound and then systematical structure activity relationship (SAR) study was conducted. These efforts led to compound 69, which exhibited potent anti-proliferative activities against MCF7 and SKBr3 breast cancer cell lines. In 4T1 mice breast cancer models, 69 exhibited potent tumor growth inhibition and anti-metastasis effect. Compound 69 as a potent antitumor agent targeting the Hsp90 C-terminal is worthy of further pre-clinical study. (C) 2017 Published by Elsevier Masson SAS.

  DOI：

  10.1016/j.ejmech.2017.07.080
• 作为产物：
  描述：

  4-甲基-6-硝基喹啉-2-醇 在 三氯氧磷 作用下， 以 乙醇 为溶剂， 反应 30.0h， 生成 4-甲基-6-硝基-2-哌啶-1-基喹啉
  参考文献：
  名称：

  Identification and optimization of novel 6-acylamino-2-aminoquinolines as potent Hsp90 C-terminal inhibitors

  摘要：

  In order to discover novel Hsp90 inhibitors targeting the C-terminal ATP binding pocket, a novobiocin derivative based ROCS model was constructed for virtual screening. Compound 13 was identified as the lead compound and then systematical structure activity relationship (SAR) study was conducted. These efforts led to compound 69, which exhibited potent anti-proliferative activities against MCF7 and SKBr3 breast cancer cell lines. In 4T1 mice breast cancer models, 69 exhibited potent tumor growth inhibition and anti-metastasis effect. Compound 69 as a potent antitumor agent targeting the Hsp90 C-terminal is worthy of further pre-clinical study. (C) 2017 Published by Elsevier Masson SAS.

  DOI：

  10.1016/j.ejmech.2017.07.080

文献信息

• 218. Attempts to find new antimalarials. Part XVII. Derivatives of 5 : 6 : 3′ : 2′-pyridoquinoline
  作者：William O. Kermack、Alice P. Weatherhead

  DOI：10.1039/jr9400001164

  日期：——