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N,N-diisopropyl-4-methoxypyridine-3-carbamate | 437709-73-4

中文名称
——
中文别名
——
英文名称
N,N-diisopropyl-4-methoxypyridine-3-carbamate
英文别名
(4-methoxypyridin-3-yl) N,N-di(propan-2-yl)carbamate
N,N-diisopropyl-4-methoxypyridine-3-carbamate化学式
CAS
437709-73-4
化学式
C13H20N2O3
mdl
——
分子量
252.313
InChiKey
PQIBJCJAJPTOLD-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    2.2
  • 重原子数:
    18
  • 可旋转键数:
    5
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.54
  • 拓扑面积:
    51.7
  • 氢给体数:
    0
  • 氢受体数:
    4

上下游信息

  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    N,N-diisopropyl-4-methoxypyridine-3-carbamate正丁基锂 、 selenium(IV) oxide 、 仲丁基锂苯基锂二异丙胺 、 zinc(II) chloride 作用下, 以 四氢呋喃1,4-二氧六环乙醚正己烷环己烷 为溶剂, 反应 91.0h, 生成 6-formyl-N,N-diisopropyl-4-methoxy-2,2'-bipyridine-3-carbamate
    参考文献:
    名称:
    First Synthesis of Caerulomycin B. A New Synthesis of Caerulomycin C
    摘要:
    Caerulomycins produced by Streptomyces caeruleus are bipyridinic molecules endowed with antibiotic properties. The first synthesis of caerulomycin B (1) as well as a new synthesis of caerulomycin C (2) are reported. Starting from 3-hydroxypyridine, the same methodology was used to prepare both compounds 1 and 2. Efficiently controlled reactions such as metalation to allow the synthesis of 2,6-diiodo-3,4-dialkoxypyridines, which are key intermediates, and further halogen lithium exchange and cross-coupling to reach the targets molecules 1 and 2 have been developed.
    DOI:
    10.1021/jo010913r
  • 作为产物:
    描述:
    二异丙基甲胺酰氯3-羟基-4-甲氧基吡啶吡啶 作用下, 反应 4.0h, 以97%的产率得到N,N-diisopropyl-4-methoxypyridine-3-carbamate
    参考文献:
    名称:
    First Synthesis of Caerulomycin B. A New Synthesis of Caerulomycin C
    摘要:
    Caerulomycins produced by Streptomyces caeruleus are bipyridinic molecules endowed with antibiotic properties. The first synthesis of caerulomycin B (1) as well as a new synthesis of caerulomycin C (2) are reported. Starting from 3-hydroxypyridine, the same methodology was used to prepare both compounds 1 and 2. Efficiently controlled reactions such as metalation to allow the synthesis of 2,6-diiodo-3,4-dialkoxypyridines, which are key intermediates, and further halogen lithium exchange and cross-coupling to reach the targets molecules 1 and 2 have been developed.
    DOI:
    10.1021/jo010913r
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文献信息

  • First Synthesis of Caerulomycin B. A New Synthesis of Caerulomycin C
    作者:Florence Mongin、François Trécourt、Bruno Gervais、Olivier Mongin、Guy Quéguiner
    DOI:10.1021/jo010913r
    日期:2002.5.1
    Caerulomycins produced by Streptomyces caeruleus are bipyridinic molecules endowed with antibiotic properties. The first synthesis of caerulomycin B (1) as well as a new synthesis of caerulomycin C (2) are reported. Starting from 3-hydroxypyridine, the same methodology was used to prepare both compounds 1 and 2. Efficiently controlled reactions such as metalation to allow the synthesis of 2,6-diiodo-3,4-dialkoxypyridines, which are key intermediates, and further halogen lithium exchange and cross-coupling to reach the targets molecules 1 and 2 have been developed.
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