3,7,11,15-tetramethyl-hexadeca-2,6,10,14-tetraenal | 32480-11-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3,7,11,15-tetramethyl-hexadeca-2,6,10,14-tetraenal
• 英文别名: 3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraenal
• CAS: 32480-11-8
• 化学式: C₂₀H₃₂O
• 分子量: 288.473
• InChiKey: AVHRJMXIKKJVHG-UHFFFAOYSA-N

物化性质

• 沸点：
  402.7±24.0 °C(Predicted)
• 密度：
  0.875±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  21
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3,7,11,15-tetramethyl-hexadeca-2,6,10,14-tetraenal 在 甲醇 、 manganese(IV) oxide 、 硼氘化钠 作用下， 以 二氯甲烷 为溶剂， 反应 0.34h， 生成
  参考文献：
  名称：

  使用 MnO2 将醇-d1 选择性氧化为醛-d1

  摘要：

  醇-d 1的选择性氧化制备醛-d 1是通过NaBD 4还原/活化的MnO 2氧化的新方法。各种醛-d 1衍生物，包括芳族和不饱和醛-d 1都可以以高氘掺入率（高达 98% D）制备。在温和条件下，底物中的卤素（氯化物、溴化物和碘化物）、烯烃、炔烃、酯、硝基和氰基是可耐受的。

  DOI：

  10.1039/d1ra05405h
• 作为产物：
  描述：

  全氟聚醚基表面活性剂FLUOROLINKD10-H 在 manganese(IV) oxide 作用下， 以 二氯甲烷 为溶剂， 生成 3,7,11,15-tetramethyl-hexadeca-2,6,10,14-tetraenal
  参考文献：
  名称：

  使用 MnO2 将醇-d1 选择性氧化为醛-d1

  摘要：

  醇-d 1的选择性氧化制备醛-d 1是通过NaBD 4还原/活化的MnO 2氧化的新方法。各种醛-d 1衍生物，包括芳族和不饱和醛-d 1都可以以高氘掺入率（高达 98% D）制备。在温和条件下，底物中的卤素（氯化物、溴化物和碘化物）、烯烃、炔烃、酯、硝基和氰基是可耐受的。

  DOI：

  10.1039/d1ra05405h

文献信息

• Preparations of 5-alkylmethylidene-3-carboxymethylrhodanine derivatives and their aldose reductase inhibitory activity.
  作者：Yoshitaka OHISHI、Teruo MUKAI、Michiko NAGAHARA、Motoyuki YAJIMA、Norio KAJIKAWA、Kazumoto MIYAHARA、Tsunehiro TAKANO

  DOI：10.1248/cpb.38.1911

  日期：——

  Reactions of 3-carboxymethylrhodanine (1) with aldehydes (2a-u) afforded stereoselectively the 5-monoalkymethylidene-3-carboxymethylrhodanines (3a-u). The configuration of the 5-monoalkylmethylidene-3-carboxymethylrhodanine (3k) were examined by X-ray structure analysis and confirmed to be Z-configuration. The stereoselective reaction path was discussed. Several 5-dialkylmethylidene-3-carboxymethylrhodanines (15a-f) and alkyl-amino derivatives of 3-carboxymethylrhodanines (18a-o) were also prepared.These products were evaluated for aldose reductase-inhibitory potency and half of them exhibited valuable inhibitory potency.

  3-羧甲基罗丹宁（1）与醛（2a-u）反应，选择性地生成了5-单烷亚甲基-3-羧甲基罗丹宁（3a-u）。通过X射线结构分析，确认5-单烷亚甲基-3-羧甲基罗丹宁（3k）的构型为Z型。讨论了立体选择性反应途径。还合成了几种5-二烷亚甲基-3-羧甲基罗丹宁（15a-f）和3-羧甲基罗丹宁的烷基氨基衍生物（18a-o）。这些产物被评估了醛糖还原酶抑制活性，其中一半显示出了有价值的抑制活性。
• The Rearrangement of ?-Acetylenic Alcohols to ?, ?-Unsaturated Carbonyl Compounds by Silylvanadate Catalysts
  作者：Horst Pauling、David Arthur Andrews、Nathan Chadwick Hindley

  DOI：10.1002/hlca.19760590426

  日期：1976.6.2

  New catalytic systems have been found which effect the isomerization of α-acetylenic alcohols to the corresponding α, β-unsaturated carbonyl compounds with high efficiency. These are combinations of silylvanadates with silanols or silanediols.

  已经发现了新的催化体系，其可以高效地将α-炔醇异构化为相应的α，β-不饱和羰基化合物。这些是硅烷基钒酸盐与硅烷醇或硅烷二醇的组合。
• Rhodanine derivative, process for preparing the same and pharmaceutical composition containing the same
  申请人：Kaken Pharmaceutical Co., Ltd.

  公开号：EP0143461A2

  公开（公告）日：1985-06-05

  A rhodanine derivative having the following general formula (I): wherein R is an acyclic alkyl group having 2 to 10 carbon atoms which may be substituted by a halogen atom; an acyclic alkenyl group having 2 to 19 carbon atoms which may be substituted by a halogen atom; a mono- or di-alkylamino group having 1 to 6 carbon atoms which may be substituted by a hydroxyl group; an alkenylamino group having 3 to 6 carbon atoms; a phenylamino group, the benzene ring of which may be substituted by a lower alkyl group, a lower alkoxyl group, phenyl group or a halogen atom; or a cyclic amino group which may contain in the ring an oxygen atom or a nitrogen atom to which a lower alkyl group is attached; or a nontoxic salt thereof. The rhodanine derivative has potent platelet aggregation inhibiting activity and aldose reductase inhibiting activity and therefore is useful as a therapeutic agent for diabetic complications.

  具有以下通式(I)的罗丹宁衍生物： 其中 R 是具有 2 至 10 个碳原子、可被卤素原子取代的无环烷基；具有 2 至 19 个碳原子、可被卤素原子取代的无环烯基；具有 1 至 6 个碳原子、可被羟基取代的单烷基或二烷基氨基；具有 3 至 6 个碳原子的烯胺基；苯胺基，其苯环可被低级烷基、低级烷氧基、苯基或卤素原子取代；或环状氨基，其环中可含有一个氧原子或一个氮原子，并与低级烷基相连；或其无毒盐。罗丹宁衍生物具有强效的血小板聚集抑制活性和醛糖还原酶抑制活性，因此可用作糖尿病并发症的治疗剂。
• PHEROMONDISPENSER
  申请人：BASF SE

  公开号：EP2384111A1

  公开（公告）日：2011-11-09
• PHEROMONE DISPENSER
  申请人：Harmsen Sven

  公开号：US20110266361A1

  公开（公告）日：2011-11-03

  The present invention relates to a pheromone dispenser, filled with pheromone or a pheromone-comprising liquid and comprising (a) a deep-drawn plastic film made of a thermoplastic film material and featuring at least one dish-shaped zone for receiving a pheromone, and a planar plastic film made of a thermoplastic film material and which is connected with the deep-drawn plastic film, the planar plastic film together with the at least one dish-shaped zone of the deep-drawn plastic film forming a durably sealed chamber which comprises the pheromone or the pheromone-comprising liquid, and (c) a recess in the zone of the interconnected plastic films, the planar plastic film being permeable to the pheromone. The invention also relates to a process for producing such a pheromone dispenser.