2-norbornylphosphonous dichloride | 73787-68-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-norbornylphosphonous dichloride
• 英文别名: 2-Bicyclo[2.2.1]heptanyl(dichloro)phosphane；2-bicyclo[2.2.1]heptanyl(dichloro)phosphane
• CAS: 73787-68-5；73787-75-4
• 化学式: C₇H₁₁Cl₂P
• 分子量: 197.044
• InChiKey: WUXDKPXKVYOBOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  甲醇 、 2-norbornylphosphonous dichloride 在 三乙胺 作用下， 以 乙醚 为溶剂， 生成 dimethyl endo-2-norbornylphosphonite 、 dimethyl exo-2-norbornylphosphonite
  参考文献：
  名称：

  Phosphorus-31 and carbon-13 NMR spectra of 2-norbornyl phosphorus compounds. Karplus equations for 3JPC in several phosphorus(III) and phosphorus(IV) derivatives

  摘要：

  DOI：

  10.1021/ja00529a042

文献信息

• METHOD FOR PREPARING HALOGENATED ORGANOPHOSPHINES
  申请人：Zavorine Serguei I.

  公开号：US20110071319A1

  公开（公告）日：2011-03-24

  The present application relates to a process for preparing a halogenated organophosphine, comprising reacting a primary or secondary organophosphine with a halogenating agent selected from (A) a compound of formula (I): (HaI) 3 C—C(O)—X (I) wherein X is selected from alkyl, aryl, aralkyl, alkaryl, cycloalkyl, NR 1 R 2 , C(HaI) 3 , OR 3 , -0—C(O)—R 3′ , or —Y—Z—Y—C(O)—C(HaI) 3 ; R1 and R2 are each independently selected from hydrogen, alkyl, aryl, aralkyl, alkaryl, or cycloalkyl; R3 is selected from H, alkyl, aryl, aralkyl, alkaryl, cycloalkyl, or triorganosilyl; R 3′ is selected from C(HaI) 3 , alkyl, aryl, aralkyl, alkaryl, cycloalkyl; Y is independently selected from 0 or NH; Z is independently selected from alkylene, arylene, aralkylene, alkarylene, or cycloakylene; and Hal is selected from Cl or Br; or (B) a derivative of a polyol, polyamine or polyaminoalcohol comprising two or more hydroxyl and/or amino groups, in which a hydrogen atom in each of the hydroxyl and/or amino groups is replaced with a group —C(O)—C(HaI) 3 , wherein Hal is selected from Cl or Br.

  本申请涉及一种制备卤代有机膦的方法，包括将一种一级或二级有机膦与一种卤化试剂反应，所述卤化试剂选自以下组合物：（A）式（I）的化合物：（HaI）3C—C（O）—X（I），其中X选自烷基、芳基、芳基烷基、烷芳基、环烷基、NR1R2、C（HaI）3、OR3、-0—C（O）—R3'或—Y—Z—Y—C（HaI）3；R1和R2各自独立地选自氢、烷基、芳基、芳基烷基、烷芳基或环烷基；R3选自H、烷基、芳基、芳基烷基、烷芳基、环烷基或三有机硅基；R3'选自C（HaI）3、烷基、芳基、芳基烷基、烷芳基或环烷基；Y各自独立地选自0或NH；Z各自独立地选自烷基、芳基、芳基烷基、烷芳基或环烷基；Hal选自Cl或Br；或（B）一种多元醇、多胺或多胺醇的衍生物，其中包含两个或两个以上的羟基和/或氨基团，其中每个羟基和/或氨基团中的一个氢原子被一个基团—C（O）—C（HaI）3所取代，其中Hal选自Cl或Br。
• [EN] METHOD FOR PREPARING HALOGENATED ORGANOPHOSPHINES<br/>[FR] PROCÉDÉ POUR LA FABRICATION D'ORGANOPHOSPHINES HALOGÉNÉES
  申请人：CYTEC CANADA INC

  公开号：WO2009147495A2

  公开（公告）日：2009-12-10

  The present application relates to a process for preparing a halogenated organophosphine, comprising reacting a primary or secondary organophosphine with a halogenating agent selected from (A) a compound of formula (I) : (HaI)3C-C(O)-X (I) wherein X is selected from alkyl, aryl, aralkyl, alkaryl, cycloalkyl, NR1R2, C(HaI)3, OR3, -0-C(O)-R3', or -Y-Z-Y-C(O)- C(HaI)3; R1 and R2 are each independently selected from hydrogen, alkyl, aryl, aralkyl, alkaryl, or cycloalkyl; R3 is selected from H, alkyl, aryl, aralkyl, alkaryl, cycloalkyl, or triorganosilyl; R3' is selected from C(HaI)3, alkyl, aryl, aralkyl, alkaryl, cycloalkyl; Y is independently selected from 0 or NH; Z is independently selected from alkylene, arylene, aralkylene, alkarylene, or cycloakylene; and Hal is selected from Cl or Br; or (B) a derivative of a polyol, polyamine or polyaminoalcohol comprising two or more hydroxyl and/or amino groups, in which a hydrogen atom in each of the hydroxyl and/or amino groups is replaced with a group -C(O)-C(HaI)3, wherein Hal is selected from Cl or Br.
• Phosphorus-31 and carbon-13 NMR spectra of 2-norbornyl phosphorus compounds. Karplus equations for 3JPC in several phosphorus(III) and phosphorus(IV) derivatives
  作者：Louis D. Quin、Michael J. Gallagher、Glen T. Cunkle、Donald B. Chesnut

  DOI：10.1021/ja00529a042

  日期：1980.4