3-(α-cyclohexylphenylmethyl)tetrahydrofuran-2-one | 143994-33-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 3-(α-cyclohexylphenylmethyl)tetrahydrofuran-2-one
• 英文别名: 3-[Cyclohexyl(phenyl)methyl]oxolan-2-one
• CAS: 143994-33-6
• 化学式: C₁₇H₂₂O₂
• 分子量: 258.36
• InChiKey: SHCDKFNLNCWGHQ-UHFFFAOYSA-N

物化性质

• 沸点：
  413.2±14.0 °C(Predicted)
• 密度：
  1.102±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(α-cyclohexylphenylmethyl)tetrahydrofuran-2-one 在 三乙烯二胺 、 sodium periodate 、 lithium cyclohexylisopropylamide 作用下， 反应 18.67h， 生成 8-cyclohexyl-3,3a,8,8a-tetrahydro-1H-indeno<1,2-c>furan-1-one
  参考文献：
  名称：

  Furan-2(3H)- and 2(5H)-ones. Part 5. Photoreactions of 3-benzylfuran2(5H)-ones; cyclisation to indenofuranones

  摘要：

  The effect of substitution at the 'central methane' on the photoreactivity of 3-benzylfuran-2(5H)ones 5a-g was investigated. Despite its di-pi-methane structure, photochemical arylation was effected to give substituted indenofuranones 6 in good yields. Only the substitution by phenyl caused the di-pi-methane rearrangement to give a cyclopropanofuranone 18g in moderate yield.

  DOI：

  10.1039/p19940001833
• 作为产物：
  描述：

  环己基苯基甲酮 在 palladium on activated charcoal 盐酸 、 dimethyl sulfide borane 、 氢气 、 sodium hydride 作用下， 以 溶剂黄146 为溶剂， 生成 3-(α-cyclohexylphenylmethyl)tetrahydrofuran-2-one
  参考文献：
  名称：

  Furan-2(3H)- and 2(5H)-ones. Part 5. Photoreactions of 3-benzylfuran2(5H)-ones; cyclisation to indenofuranones

  摘要：

  The effect of substitution at the 'central methane' on the photoreactivity of 3-benzylfuran-2(5H)ones 5a-g was investigated. Despite its di-pi-methane structure, photochemical arylation was effected to give substituted indenofuranones 6 in good yields. Only the substitution by phenyl caused the di-pi-methane rearrangement to give a cyclopropanofuranone 18g in moderate yield.

  DOI：

  10.1039/p19940001833

文献信息

• A Breakthrough for the Photochemical Arylation in the 3-(Phenylmethyl)-2(5H)-furanone system Leading to the Tetrahydroindenofuranone System
  作者：Osamu Muraoka、Genzoh Tanabe、Kyoko Sano、Takefumi Momose

  DOI：10.3987/com-92-6034

  日期：——

  The photochemistry of the 'central methane'-substituted 3-benzyl-2(5H)-furanone system (1) is described. Despite its di-pi-methane structure, photochemical arylation was found to predominate in place of the di-pi-methane rearrangement, and gave substituted tetrahydroindenofuranones (2) in good yields.
• Furan-2(3H)- and 2(5H)-ones. Part 5. Photoreactions of 3-benzylfuran2(5H)-ones; cyclisation to indenofuranones
  作者：Osamu Muraoka、Genzoh Tanabe、Kyohko Sano、Toshie Minematsu、Takefumi Momose

  DOI：10.1039/p19940001833

  日期：——

  The effect of substitution at the 'central methane' on the photoreactivity of 3-benzylfuran-2(5H)ones 5a-g was investigated. Despite its di-pi-methane structure, photochemical arylation was effected to give substituted indenofuranones 6 in good yields. Only the substitution by phenyl caused the di-pi-methane rearrangement to give a cyclopropanofuranone 18g in moderate yield.