3,4-Dihydroxychinolin | 90348-01-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3,4-Dihydroxychinolin
• 英文别名: quinoline-3,4-diol
• CAS: 90348-01-9
• 化学式: C₉H₇NO₂
• mdl: MFCD09753667
• 分子量: 161.16
• InChiKey: BHTNYVRPYQQOMJ-UHFFFAOYSA-N

物化性质

• 熔点：
  280-315 °C
• 沸点：
  373.9±22.0 °C(Predicted)
• 密度：
  1.418±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,4-Dihydroxychinolin 在 chromium(VI) oxide 、 溶剂黄146 作用下， 生成 4-Aza-naphthochinon-(1,2)
  参考文献：
  名称：

  A Direct Synthesis of 4-Azanaphthoquinones-1,2¹

  摘要：

  DOI：

  10.1021/jo01036a533
• 作为产物：
  描述：

  3,4-二溴喹啉 在 盐酸 作用下， 生成 3,4-Dihydroxychinolin
  参考文献：
  名称：

  Claus; Howitz, Journal fur praktische Chemie (Leipzig 1954), 1894, vol. <2> 50, p. 239

  摘要：

  DOI：

文献信息

• Heterocycles that are inhibitors of IMPDH enzyme
  申请人：——

  公开号：US20020040022A1

  公开（公告）日：2002-04-04

  Compounds of the formula 1 wherein X 1 is C(O), —S(O)—, or —S(O) 2 —; X 2 is CR 3 or N; X 3 is —NH—, —O—, or —S—; X 4 is CR 4 or N; X 5 is CR 5 or N; and X 6 is CR 6 or N are useful as inhibitors of IMPDH enzyme. Thus, these compounds can be used as therapeutic agents for IMPDH-associated disorders.

  公式1中的化合物，其中X1是C(O)、—S(O)—或—S(O)2—；X2是CR3或N；X3是—NH—、—O—或—S—；X4是CR4或N；X5是CR5或N；X6是CR6或N，可用作IMPDH酶的抑制剂。因此，这些化合物可作为治疗IMPDH相关疾病的治疗剂。
• Activators for peroxygenated compounds
  申请人：3V Sigma S.P.A.

  公开号：US20180010075A1

  公开（公告）日：2018-01-11

  Disclosed is a compound of formula I wherein R 1 is a straight, branched or cyclic, saturated or unsaturated acyl group having 2 to 5 carbon atoms; R 2 is a straight, branched or cyclic, saturated or unsaturated acyl group having 6 to 18 carbon atoms; R 3 is a straight, branched or cyclic, saturated or unsaturated acyl or alkyl group having 2 to 18 carbon atoms; y can have a value of 0 to 3, m, n and x can independently have a value from 2 to 3; z has a value of zero or 1.

  公开的是一种具有以下结构的化合物：其中R1是具有2至5个碳原子的直链、支链或环状、饱和或不饱和酰基基团；R2是具有6至18个碳原子的直链、支链或环状、饱和或不饱和酰基基团；R3是具有2至18个碳原子的直链、支链或环状、饱和或不饱和酰基或烷基基团；y的值可以为0至3，m、n和x可以独立地取2至3的值；z的值为零或1。
• 4-ARYL-1-(BIARYLMETHYLENE) PIPERIDINE COMPOUNDS
  申请人：KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY

  公开号：US20140296528A1

  公开（公告）日：2014-10-02

  The 4-aryl-1-(biarylmethylene)piperidine compounds are piperadine compounds having a biaryl substituent linked to the nitrogen atom of the piperidine ring by a methylene (—CH 2 —) group, and an aryl moiety attached to the 4-position of the piperidine ring. The aryl moiety may be a methoxy quinoline group, a 2-oxo quinoline group, or a 2-oxo, 3,4-dihydroxy quinoline group. The biaryl substituent may be biphenyl, fluorophenyl benzene, 3-phenyl pyridine, 3-(4-fluorophenyl) pyridine, phenyl cyclopentene, or 3-(1-cyclopenten-1-yl) pyridine. The compounds are believed to be suitable for anti-psychotic medication, since they are structurally related to SLV-313, a potential atypical antipsychotic having potent D 2 receptor antagonist and 5-HT 1A receptor agonist properties.

  4-芳基-1-(联苯基亚甲基)哌啶化合物是一类哌啶化合物，其具有通过一个亚甲基(—CH2—)基团连接到哌啶环的氮原子的联苯基取代基，并且一个芳基固定在哌啶环的4-位置。芳基可能是一个甲氧基喹啉基团，一个2-氧基喹啉基团，或一个2-氧基，3,4-二羟基喹啉基团。联苯基取代基可能是联苯，氟苯基苯，3-苯基吡啶，3-(4-氟苯基)吡啶，苯基环戊烯，或3-(1-环戊烯-1-基)吡啶。这些化合物被认为适用于抗精神病药物，因为它们在结构上与SLV-313相关，SLV-313是一种潜在的非典型抗精神病药物，具有强效的D2受体拮抗剂和5-HT1A受体激动剂特性。
• COMPOSITION, METHOD OF AUTHENTICATING, METHODS OF MAKING AUTHENTICATABLE COMPOSITIONS, AUTHENTICATABLE ARTICLES MADE THERE FROM
  申请人：CHAUHAN YOGENDRASINH

  公开号：US20080265176A1

  公开（公告）日：2008-10-30

  A composition comprising compound of formula I, a process for preparing the composition comprising compound of formula I, methods of authentication for an article comprising compound of formula I or compound of formula II, authentication technology for polymer based articles comprising compound of formula I or formula II, methods of facilitating such authentication and method of making articles capable of authentication.

  一种化合物I组成的组合物，制备该组合物的过程，用于鉴别含有化合物I或化合物II的物品的方法，基于化合物I或化合物II的聚合物制品的鉴别技术，促进此类鉴别的方法以及制作能够鉴别的物品的方法。
• ANTIBACTERIAL COMPOUNDS
  申请人：GLAXO GROUP LIMITED

  公开号：US20140249126A1

  公开（公告）日：2014-09-04

  The present invention relates to cephalosporin antibacterial compounds of Formula (I): or corresponding pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods for bacterial infections, especially those caused by gram-negative bacteria.

  本发明涉及式（I）的头孢菌素抗菌化合物：或其相应的药学上可接受的盐，相应的制药组合物，化合物制备和治疗细菌感染的方法，特别是由革兰氏阴性菌引起的感染。