1-aza-7,14-dioxadispiro[4.2.5.2]pentadecan-2-one | 956512-92-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-aza-7,14-dioxadispiro[4.2.5.2]pentadecan-2-one
• 英文别名: 7,14-Dioxa-4-azadispiro[4.2.58.25]pentadecan-3-one；7,14-dioxa-4-azadispiro[4.2.58.25]pentadecan-3-one
• CAS: 956512-92-8
• 化学式: C₁₂H₁₉NO₃
• 分子量: 225.288
• InChiKey: DIDZDDVCOHHHDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-aza-7,14-dioxadispiro[4.2.5.2]pentadecan-2-one 在 吡啶 、 N,O-双三甲硅基乙酰胺 、 sodium hydride 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 193.0h， 生成 1-{[5',5'-bis(pivaloyloxymethyl)pyrrolidin-2'-on-1'-yl]methyl}-1H,3H-pyrimidine-2,4-dione
  参考文献：
  名称：

  Synthesis and antiviral properties of aza-analogues of ganciclovir derived from 5,5-bis(hydroxymethyl)pyrrolidin-2-one

  摘要：

  Novel aza-analogues of ganciclovir were obtained from 1,5,5-tris(pivaloyloxymethyl)pyrrolidin-2-one by a one-pot base silylation/nucleoside coupling procedure. The compounds were evaluated for, but found to be devoid of, antiviral activity in vitro. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.08.032
• 作为产物：
  描述：

  3-硝基-1,5-二氧杂螺[5.5]十一烷 在 palladium on activated charcoal 氢气 、 四甲基胍 作用下， 以 甲醇 为溶剂， 70.0 ℃ 、5.0 MPa 条件下， 反应 29.25h， 生成 1-aza-7,14-dioxadispiro[4.2.5.2]pentadecan-2-one
  参考文献：
  名称：

  Synthesis and antiviral properties of aza-analogues of ganciclovir derived from 5,5-bis(hydroxymethyl)pyrrolidin-2-one

  摘要：

  Novel aza-analogues of ganciclovir were obtained from 1,5,5-tris(pivaloyloxymethyl)pyrrolidin-2-one by a one-pot base silylation/nucleoside coupling procedure. The compounds were evaluated for, but found to be devoid of, antiviral activity in vitro. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.08.032

文献信息

• Synthesis and antiviral properties of aza-analogues of ganciclovir derived from 5,5-bis(hydroxymethyl)pyrrolidin-2-one
  作者：Mariola Koszytkowska-Stawińska、Ewa Kołaczkowska、Ewa Adamkiewicz、Erik De Clercq

  DOI：10.1016/j.tet.2007.08.032

  日期：2007.10

  Novel aza-analogues of ganciclovir were obtained from 1,5,5-tris(pivaloyloxymethyl)pyrrolidin-2-one by a one-pot base silylation/nucleoside coupling procedure. The compounds were evaluated for, but found to be devoid of, antiviral activity in vitro. (C) 2007 Elsevier Ltd. All rights reserved.